A5055366293- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Immune responses and vaccinations
- Long-Term Effects of COVID-19
- Single-cell and spatial transcriptomics
- Vitamin K Research Studies
- Renal and related cancers
- Signaling Pathways in Disease
- vaccines and immunoinformatics approaches
- Cell Adhesion Molecules Research
- Extracellular vesicles in disease
- Organ Transplantation Techniques and Outcomes
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- T-cell and B-cell Immunology
- Liver Disease and Transplantation
- Cardiac Fibrosis and Remodeling
- Renal Transplantation Outcomes and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer-related gene regulation
- Vitamin C and Antioxidants Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
RWTH Aachen University
2021-2025
Universitätsklinikum Aachen
2021
Fibrosis represents the uncontrolled replacement of parenchymal tissue with extracellular matrix (ECM) produced by myofibroblasts. While genetic fate-tracing and single-cell RNA-Seq technologies have helped elucidate fibroblast heterogeneity ontogeny beyond to myofibroblast differentiation, newly identified populations remain ill defined, respect both molecular cues driving their differentiation subsequent role in fibrosis. Using an unbiased approach, we metalloprotease ADAMTS12 as a...
Abstract Background Patients with acute decompensation (AD) of cirrhosis are at high risk developing acute-on-chronic liver failure (ACLF), a syndrome characterized by multiple organ and short-term mortality. This study aimed to analyse alterations in peripheral blood mononuclear cells (PBMCs) patients AD using single-cell technologies explore their implications for stratification prognosis. Methods A total 63 15 healthy donors were enrolled five European centers, samples collected upon...
Introduction SARS-CoV-2 infection results in varying disease severity, ranging from asymptomatic to severe illness. A detailed understanding of the immune response is critical unravel causative factors underlying differences severity and develop optimal vaccines against new variants. Methods We combined single-cell RNA T cell receptor sequencing with CITE-seq antibodies characterize CD8 + at high resolution compared responses between mild COVID-19. Results observed increased exhaustion...
Abstract The current COVID-19 pandemic represents a global challenge. A better understanding of the immune response against SARS-CoV-2 is key to unveil differences in disease severity and develop future vaccines targeting novel variants. Feature barcode technology combined with CITE-seq antibodies DNA-barcoded peptide-MHC I Dextramer reagents enabled us identify relevant SARS-CoV-2-derived epitopes compare epitope-specific CD8 + T cell populations between mild severe COVID-19. We identified...