A5029224865- HIV Research and Treatment
- Parathyroid Disorders and Treatments
- Hormonal Regulation and Hypertension
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Potassium and Related Disorders
- Bacteriophages and microbial interactions
- Cancer, Lipids, and Metabolism
- Antimicrobial agents and applications
- Lipoproteins and Cardiovascular Health
- Dialysis and Renal Disease Management
- Vitamin K Research Studies
- Antimicrobial Peptides and Activities
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Magnesium in Health and Disease
- Vitamin C and Antioxidants Research
- Vitamin D Research Studies
- Immune Cell Function and Interaction
- Tryptophan and brain disorders
Maastricht University
2022-2025
RWTH Aachen University
2020-2022
Universitätsklinikum Aachen
2020-2021
Instituto de Química Médica
2018-2021
Consejo Superior de Investigaciones Científicas
2018
Patients with chronic kidney disease (CKD) show a high risk of cardiovascular diseases, predominantly caused by accelerated vascular calcification. Vascular calcification is highly regulated process no current treatment. The vasoconstriction-inhibiting factor (VIF) peptide was recently discovered vasoregulatory properties, but information regarding has been described. In the present work, inhibitory effect VIF analysed in vitro smooth muscle cells (VSMCs), ex vivo rat aortic rings, as well...
We have recently described a new generation of potent human immunodeficiency virus (HIV) and EV-A71 entry inhibitors. The prototypes contain three or four tryptophan (Trp) residues bearing an isophthalic acid moiety at the C2 position each side-chain indole ring. This work is now extended by both shifting to C7 synthesizing doubly arylated C2/C7 derivatives. most derivative (50% effective concentration (EC50) HIV-1, 6 nM; EC50 EV-A71, 40 nM), 33 (AL-518), tetrapodal compound. Its superior...
Cationic and non-peptide small molecules containing a total of six positive charges arranged on one side long aliphatic tail the other have been synthesized tested against Gram-positive Gram-negative bacteria. The contributed by two aminophenol residues. These showed remarkable antimicrobial activity bacteria including multidrug-resistant strains. Our structure–activity relationship studies demonstrated importance length flexibility hydrophobic for activity. Importantly, these compounds are...