A5019116070- Alzheimer's disease research and treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Dementia and Cognitive Impairment Research
- Mitochondrial Function and Pathology
- Metabolomics and Mass Spectrometry Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Traumatic Brain Injury Research
- Immunotoxicology and immune responses
- Fatty Acid Research and Health
- Computational Drug Discovery Methods
- Diet and metabolism studies
- Nuclear Receptors and Signaling
- Health, psychology, and well-being
- Metabolism and Genetic Disorders
- Alcoholism and Thiamine Deficiency
- Eicosanoids and Hypertension Pharmacology
- Cholinesterase and Neurodegenerative Diseases
- Peroxisome Proliferator-Activated Receptors
- Neuropeptides and Animal Physiology
- Protease and Inhibitor Mechanisms
- MicroRNA in disease regulation
- Medicinal Plants and Neuroprotection
- Neurological Disease Mechanisms and Treatments
Roskamp Institute
2015-2024
James A. Haley Veterans' Hospital
2015-2024
Radboud University Nijmegen
2024
Radboud University Medical Center
2024
University of Leicester
2024
Trinity College Dublin
2024
University of Copenhagen
2024
St. Vincent's University Hospital
2024
The Open University
2011-2023
Kuwait Petroleum Corporation (Kuwait)
2023
As the lipidomics field continues to advance, self-evaluation within community is critical. Here, we performed an interlaboratory comparison exercise for using Standard Reference Material (SRM) 1950-Metabolites in Frozen Human Plasma, a commercially available reference material. The study comprised 31 diverse laboratories, with each laboratory different workflow. A total of 1,527 unique lipids were measured across all laboratories and consensus location estimates associated uncertainties...
<b><i></i></b><i>APOE</i> has been demonstrated to influence traumatic brain injury (TBI) outcome. The relationship between <i>APOE</i> genotype and memory following TBI was examined in 110 participants the Defense Veterans' Head Injury Program. Memory performance worse those who had an ε4 allele (n = 30) than did not 80), whereas groups differ on demographic or variables measures of executive functioning. These data support a specific role for APOE protein outcome TBI, suggest...
Early stages of many neurodegenerative diseases, such as Alzheimer's disease, vascular and frontotemporal dementia, Parkinson's are frequently associated with Mild Cognitive Impairment (MCI). A minimally invasive screening test for early detection MCI may be used to select optimal patient groups in clinical trials, monitor disease progression response treatment, better plan care. Here, we examined the feasibility using pairs brain-enriched plasma microRNA (miRNA), at least one which is...
A minimally invasive test for early detection and monitoring of Alzheimer's other neurodegenerative diseases is a highly unmet need drug development planning patient care. Mild Cognitive Impairment (MCI) syndrome characteristic stages many diseases. Recently, we have identified two sets circulating brain-enriched miRNAs, the miR-132 family (miR-128, miR-132, miR-874) normalized per miR-491-5p miR-134 (miR-134, miR-323-3p, miR-382) miR-370, capable differentiating MCI from age-matched control...
Exposure to repetitive mild traumatic brain injury (mTBI) is a risk factor for chronic encephalopathy, which characterized by patchy deposition of hyperphosphorylated tau aggregates in neurons and astrocytes at the depths cortical sulci. We developed an mTBI paradigm explore effects concussive-type over several months mice with human genetic background (hTau). Two injuries were induced hTau weekly period 3 or 4 compared those noninjured sham animals. Behavioral vivo measures detailed...
Mounting evidence suggests that cholesterol may contribute to the pathogenesis of Alzheimer disease (AD). We examined whether might be present in senile plaques, a hallmark neuropathological feature AD. employed 2 different fluorometric-staining techniques (filipin staining and an enzymatic technique) for determination brains postmortem confirmed AD patients nondemented, age-matched histopathologically normal controls. patient showed abnormal accumulation congophilic/birefringent dense cores...
Phospholipid (PL) abnormalities are observed in the cerebrospinal fluid of patients with traumatic brain injury (TBI), suggesting their role TBI pathology. Therefore, PL levels were examined a mouse model that received 1.8 mm deep controlled cortical impact or craniectomy only (control). The rotarod and Barnes maze acquisition probe tests performed within 2 wk after injury, another test 3 mo postinjury. Liquid chromatography/mass spectrometry analyses on lipid extracts from several regions...
Gulf War illness ( GWI ) is a currently untreatable multi‐symptom disorder experienced by 1990–1991 Persian GW veterans. The characteristic hallmarks of include cognitive dysfunction, tremors, migraine, and psychological disturbances such as depression anxiety. Meta‐analyses epidemiological studies have consistently linked these symptomatic profiles to the combined exposure agents organophosphate‐based pyrethroid‐based pesticides (e.g. chlorpyrifos CPF permethrin PER respectively)...
Gulf War Illness (GWI) is a chronic multisymptom illness with central nervous system component such as memory deficits, neurological, and musculoskeletal problems. There are ample data that demonstrate exposure to (GW) agents, pyridostigmine bromide (PB) pesticides permethrin (PER), were key contributors the etiology of GWI post deployment Persian GW. In current study, we examined consequences acute (10 days) PB PER in C57BL6 mice. Learning tests performed at 18 days 5 months post-exposure....
Abstract Background Matrix metallopeptidase 9 (MMP9) has been implicated in a variety of neurological disorders, including Alzheimer’s disease (AD), where MMP9 levels are elevated the brain and cerebrovasculature. Previously our group demonstrated apolipoprotein E4 (apoE4) was less efficient regulating activity than other apoE isoforms, that inhibition facilitated beta-amyloid (Aβ) elimination across blood–brain barrier (BBB) Methods In current studies, we evaluated impact modulation on Aβ...
Objective: To investigate whether or not a coding polymorphism in the cystatin C gene (CST3) contributes risk for AD.
In the military population, there is high comorbidity between mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) due to inherent risk of psychological trauma associated with combat. These disorders present long-term neurological dysfunction remain difficult diagnose their overlapping clinical presentation. Therefore, we performed cross-sectional analysis blood samples from demographically matched soldiers (total, n = 120) mTBI, PTSD, mTBI+PTSD those who were...
This study was designed to explore the influence of apolipoprotein E (APOE) on blood phospholipids (PL) in predicting preclinical Alzheimer's disease (AD).Lipidomic analyses were also performed from an AD mouse model expressing human APOE isoforms (EFAD) and five mutations 195 cognitively normal participants, 23 who converted mild cognitive impairment (MCI)/AD within 3 years.APOE ε4-carriers converting MCI/AD had high arachidonic acid (AA)/docosahexaenoic (DHA) ratios PL compared ε4 non-ε4...
Repetitive mild traumatic brain injury (rmTBI) is a major epigenetic risk factor for Alzheimer’s disease (AD). The precise nature of how rmTBI leads to or precipitates AD pathology currently unknown. Numerous neurological conditions have shown an important role dysfunctional phospholipid metabolism as driving the pathogenesis neurodegenerative diseases. However, in and remains elusive. We hypothesized that detailed characterization would reveal profiles response TBI overlap with...
Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex illness which disproportionally affects females. This associated with immune and metabolic perturbations that may be influenced by lipid metabolism. We therefore hypothesized plasma lipids from ME/CFS patients will provide unique biomarker signature of disturbances in immune, inflammation processes ME/CFS. Methods Lipidomic analyses were performed on cohort 50 controls (50% males similar age...