A5008555731- Sleep and Wakefulness Research
- Sleep and related disorders
- Electrospun Nanofibers in Biomedical Applications
- Cannabis and Cannabinoid Research
- Wound Healing and Treatments
- Neuroscience of respiration and sleep
- Regulation of Appetite and Obesity
- Circadian rhythm and melatonin
- Advanced Sensor and Energy Harvesting Materials
- Immune cells in cancer
- Ion Transport and Channel Regulation
- Silk-based biomaterials and applications
- Diabetic Foot Ulcer Assessment and Management
- Neuroscience and Neuropharmacology Research
- RNA modifications and cancer
- Surgical Sutures and Adhesives
- Tissue Engineering and Regenerative Medicine
- Retinal and Macular Surgery
- Immune Response and Inflammation
- Intraocular Surgery and Lenses
- Biochemical and Molecular Research
- Advanced Drug Delivery Systems
- Atherosclerosis and Cardiovascular Diseases
- Hydrogels: synthesis, properties, applications
- Respiratory Support and Mechanisms
Taipei Tzu Chi Hospital
2022
Tzu Chi University
2022
Yuanpei University
2019-2021
Taipei Medical University
2010-2018
Chang Gung University
2018
National Taiwan University of Science and Technology
2011-2012
National Health Research Institutes
2011
Abstract Orexins are associated with drug relapse in rodents. Here, we show that acute restraint stress mice activates lateral hypothalamic (LH) orexin neurons, increases levels of A and 2-arachidonoylglycerol (2-AG) the ventral tegmental area (VTA), reinstates extinguished cocaine-conditioned place preference (CPP). This stress-induced reinstatement cocaine CPP depends on type 1 receptors (OX1Rs), cannabinoid (CB1Rs) diacylglycerol lipase (DAGL) VTA. In dopaminergic neurons VTA slices,...
An injection of orexin A or B into the cisterna magna rostral ventrolateral medulla (RVLM), where bulbospinal vasomotor neurons are located, elevated arterial pressure (AP) and heart rate (HR). We examined how orexins affected RVLM to regulate cardiovascular functions by using in vitro recordings neuronal activity vivo measurement rats. Orexin concentration-dependently depolarized neurons. At 100 nM, both peptides excited 42% Tetrodotoxin failed block orexin-induced depolarization. In...
Vitrectomy is a common procedure for treating ocular-related diseases. The surgery involves removing the vitreous humor from center of eye, and substitutes are needed to replace after vitrectomy. In present study, we developed colorless, transparent injectable hydrogel with appropriate refractive index as substitute. formed by oxidated hyaluronic acid (oxi-HA) cross-linked adipic dihydrazide (ADH). Hyaluronic (HA) was oxidized sodium periodate create aldehyde functional groups, which could...
Significance Pain remains an unmet medical need due to the ineffectiveness or significant side effects of current pain therapies. Peripheral neurostimulation has been used relieve for decades, but its mechanism(s) remain unsettled. Here, we established animal model median nerve stimulation by electrically stimulating PC6 (Neiguan) acupoint mice (MNS-PC6). We found MNS-PC6 can release endogenous neuropeptide (orexin) from hypothalamus inhibit responses in through endocannabinoid (an lipid...
We examined the effects of vitamin C in Pluronic F127 on diabetic wound healing. Full-thickness excision skin wounds were made normal and Wistar rats to evaluate effect saline, saline plus (antioxidant sol), F127, or sol-gel). The rate contraction, levels epidermal dermal maturation, collagen synthesis, apoptosis production tissue determined. In vitro data showed that after 6 hours air exposure, order scavenging abilities for HOCl, H(2)O(2), O(2) (-) was antioxidant sol-gel > = saline. After...
Background/Aims: Hyperlipidemia induces dysfunction in the smooth muscle cells (SMCs) of blood vessels, and vascular remodeling that ensues is a key proatherogenic factor contributing to cardiovascular events. Chemokines chemokine receptors play crucial roles remodeling. Here, we examined whether hyperlipidemia-derived CCL5 its receptor CCR5 influence SMC proliferation, phenotypic switching, explored underlying mechanisms. Methods: Thoracoabdominal aorta were isolated from wild-type,...
CTP synthase (CTPS) forms compartmentalized filaments in response to substrate availability and environmental nutrient status. However, the physiological role of mechanisms for filament assembly are not well understood. Here, we provide evidence that CTPS histidine influx during glutamine starvation. Tetramer conformation-based formation restricts enzymatic activity deprivation. protein levels remain stable presence deprivation, followed by rapid cell growth after stress relief. We...
Hypertensive subjects often exhibit exaggerated cardiovascular reactivity. An overactive orexin system underlies the pathophysiology of hypertension. We examined orexin's roles in eating-associated reactivity spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) rats. Results showed eating regular chow or palatable food (sucrose agar) was accompanied by elevated arterial pressure heart rate. In both SHRs WKY rats, responses associated with sucrose-agar consumption were greater than...