A5102799680- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Plasmonic and Surface Plasmon Research
- Advanced biosensing and bioanalysis techniques
- Circadian rhythm and melatonin
- Cannabis and Cannabinoid Research
- Adipose Tissue and Metabolism
- Gold and Silver Nanoparticles Synthesis and Applications
- Anesthesia and Neurotoxicity Research
- Neurobiology and Insect Physiology Research
- Neuropeptides and Animal Physiology
- Maternal Mental Health During Pregnancy and Postpartum
- Nerve injury and regeneration
- Spectroscopy Techniques in Biomedical and Chemical Research
- Optical Coatings and Gratings
- Photonic and Optical Devices
- Prenatal Substance Exposure Effects
- Olfactory and Sensory Function Studies
National Cheng Kung University
2014-2024
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2011-2012
Institute of Physiology and Basic Medicine
2011-2012
Tsinghua University
2009
Rutgers, The State University of New Jersey
2004
Aging is an important determinant of adult hippocampal neurogenesis as the proliferation neural stem/precursor cells (NSCs) declines dramatically before middle age. Contrary to this, physical exercise known promote neurogenesis. The objective this study investigate effects mandatory treadmill running (TR) on neurogenesis, including 1) NSCs proliferation, 2) neurite outgrowth neuronal progenitor cells, and 3) survival newborn neurons in dentate area middle-aged animals. Compared with 3-mo-old...
Chronic exercise has been reported to improve cognitive function. However, whether and how different types of affect various learning memory tasks remain uncertain. To address this issue, male BALB/c mice were trained for 4 weeks under two protocols: moderate treadmill running or voluntary wheel running. After training, their spatial aversive evaluated by a Morris water maze one‐trial passive avoidance (PA), respectively. Levels neural plasticity‐related proteins, i.e. brain‐derived...
Abstract New neurons are continuously generated in hippocampal subgranular zone throughout life, and the amount of neurogenesis is suggested to be correlated with hippocampus‐dependent function. Several extrinsic stimuli known modulate process. Among them, physical exercise has advantageous effects on brain function, while inflammation shows opposite. Herein we showed that a moderate running successfully restored peripheral lipopolysaccharide (LPS)‐impaired dentate area. LPS treatment...
Abstract Orexins are associated with drug relapse in rodents. Here, we show that acute restraint stress mice activates lateral hypothalamic (LH) orexin neurons, increases levels of A and 2-arachidonoylglycerol (2-AG) the ventral tegmental area (VTA), reinstates extinguished cocaine-conditioned place preference (CPP). This stress-induced reinstatement cocaine CPP depends on type 1 receptors (OX1Rs), cannabinoid (CB1Rs) diacylglycerol lipase (DAGL) VTA. In dopaminergic neurons VTA slices,...
Accumulation of amyloid-β (Aβ) peptides in the brain is one central pathogenic events Alzheimer's disease (AD). However, why and how Aβ aggregates within AD patients remains elusive. Previously, we demonstrated hemoglobin (Hb) binds to co-localizes with plaque vascular amyloid deposits post-mortem brains. In this study, further characterize interactions between Hb vitro vivo report following observations: 1) binding required iron-containing heme; 2) other heme-containing proteins, such as...
In vivo imaging studies have revealed deregulated presynaptic or postsynaptic function of the midbrain dopaminergic system in patients with schizophrenia. To further delineate neuropathological involvement and dopamine neurons schizophrenia, authors examined brain D(2)-family receptor transporter binding simultaneously drug-naive schizophrenia using dual-isotope single photon emission computed tomography (SPECT) technique.Eleven 12 healthy comparison subjects were recruited. Striatal...
The objective of this study was to search for biological markers associated with Alzheimer's disease (AD). Plasma specimens obtained from ten pathologically diagnosed AD patients and non-demented (ND) control subjects were analyzed by a combination 2-DE MS. This strategy allowed us identify six plasma proteins (alpha-1-antitrypsin, vitamin D-binding protein, inter-alpha-trypsin inhibitor family heavy chain-related apolipoprotein J precursor, cAMP-dependent protein kinase catalytic subunit...
Adolescence is a time of developmental changes and reorganization in the brain. It has been hypothesized that stress greater neurological impact on adolescents than adults. However, scientific evidence support this hypothesis still limited. We treated adolescent (4-week-old) adult (8-week-old) rats with social instability for 5 weeks compared subsequent structural functional to amygdala neurons. In stress-free control condition, group showed higher fear-potentiated startle responses, larger...
Closed-head injury (CHI) usually involves both physical damage of neurons and neuroinflammation. Although exercise promotes neuronal repair suppresses neuroinflammation, CHI patients currently often remain resting during the post-traumatic period. This study aimed to investigate whether how postinjury benefited brain structure function in mice after CHI. immediately caused an elevated neurological severity score, with rapid loss object recognition memory, followed by progressive...