A5102888303- Telomeres, Telomerase, and Senescence
- Hepatitis B Virus Studies
- Meteorological Phenomena and Simulations
- Immunotherapy and Immune Responses
- Hepatitis C virus research
- Skin Protection and Aging
- Atmospheric aerosols and clouds
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- Climate Change and Health Impacts
- Global Health Care Issues
- vaccines and immunoinformatics approaches
- Wind and Air Flow Studies
- Global Public Health Policies and Epidemiology
- Bacteriophages and microbial interactions
- Precipitation Measurement and Analysis
- Climate variability and models
- Hemoglobinopathies and Related Disorders
- Cutaneous Melanoma Detection and Management
- Advanced MIMO Systems Optimization
- Iron Metabolism and Disorders
- Retinal Imaging and Analysis
- COVID-19 Clinical Research Studies
- Retinal Diseases and Treatments
- Cancer Research and Treatments
Institute for Health Metrics and Evaluation
2021-2024
University of Washington
2021-2024
Wenzhou Medical University
2024
Northern Sydney Local Health District
2024
The University of Sydney
2023-2024
Institute for Musculoskeletal Health
2024
Foundation University Islamabad
2023-2024
Foundation University
2024
Paracelsus Medical University
2023
Ajou University
2016-2023
The human sirtuin 2 gene ( SIRT2 ) encodes a full-length Sirt2 protein (i.e., the isoform 1), which primarily functions as cytoplasmic α-tubulin deacetylase, and promotes growth of hepatocellular carcinoma (HCC). Hepatitis B virus (HBV) replication itself, or HBV X (HBx) protein-mediated transcriptional transactivation, enhances Sirt2.1 expression; therefore, itself is capable positively increasing transcription replication. linked to liver fibrosis epithelial-to-mesenchymal transition and,...
The purpose of this study was to build radiogenomics models from texture signatures derived computed tomography (CT) and 18F-FDG PET-CT (FDG PET-CT) images non-small cell lung cancer (NSCLC) with without epidermal growth factor receptor (EGFR) mutations.Fifty patients diagnosed NSCLC between 2011 2015 known EGFR mutation status were retrospectively identified. Texture features extracted pretreatment CT FDG by manual contouring the primary tumor used develop multivariate logistic regression...
Sirtuin 2 (Sirt2), a NAD+-dependent protein deacetylase, is overexpressed in many hepatocellular carcinomas (HCCs) and can deacetylate proteins, including tubulins AKT, prior to AKT activation. Here, we found that endogenous Sirt2 was upregulated wild-type hepatitis B virus (HBV WT)-replicating cells, leading tubulin deacetylation; however, this not the case HBV replication-deficient-mutant-transfected cells 1.3-mer WT-transfected reverse transcriptase inhibitor (entecavir or...
The HBx protein plays an essential regulatory role in HBV replication. We found that substrate-binding residues on the human parvulin peptidylprolyl cis / trans isomerase proteins Par14 and Par17 bound to conserved arginine-proline (RP) motifs cytoplasm, nucleus, mitochondria. HBx-Par14/Par17 interaction stabilized HBx; promoted its translocation nucleus mitochondria; stimulated multiple steps of replication, including cccDNA formation, RNA DNA synthesis, virion secretion. In addition,...
The efficacy of antibiotics and other antimicrobial agents in combating bacterial infections faces a grave peril the form resistance (AMR), an exceedingly pressing global health issue. emergence dissemination drug-resistant bacteria can be attributed to rampant overuse misuse antibiotics, leading dire consequences such as organ failure sepsis. Beyond realm individual health, pervasive specter AMR casts its ominous shadow upon economy society at large, resulting protracted hospital stays,...
Human parvulin peptidyl prolyl cis/trans isomerases PIN1 and PIN4 play important roles in cell cycle progression, DNA binding, protein folding chromatin remodeling, ribosome biogenesis, tubulin polymerization. In this article, we found that endogenous were upregulated selected hepatocellular carcinoma (HCC) lines.In study, inhibited via inhibitors (Juglone, PiB, ATRA, 6,7,4'-THIF, KPT6566, EGCG). The native agarose gel electrophoresis (NAGE) immunoblotting analysis revealed upon and/ or...
Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare outcomes patients discharged with versus opioid-free common surgical procedures.
A solution based on a Kalman filter to trace the evolution of atmospheric boundary layer (ABL) sensed by ground-based elastic-backscatter tropospheric lidar is presented. An erf-like profile used model mixing-layer top and entrainment-zone thickness. The extended (EKF) enables retrieve track ABL parameters simplified statistics dynamics observation noise present in signal. This adaptive feature permits analyze scenes with low signal-to-noise ratios (SNRs) without need resort long-time...
Purpose: Telomerase promoter mutations are highly prevalent in human tumors including melanoma. A subset of patients with metastatic melanoma often fail multiple therapies, and there is an unmet urgent need to prolong disease control for those patients.Experimental Design: Numerous preclinical therapy-resistant models mouse were used test the efficacy a telomerase-directed nucleoside, 6-thio-2'-deoxyguanosine (6-thio-dG). Integrated transcriptomics proteomics approaches identify genes...
Sirtuin 2 (Sirt2), an NAD+-dependent protein deacetylase, deacetylates tubulin, AKT, and other proteins. Previously, we showed that Sirt2 isoform 1 (Sirt2.1) increased replication of hepatitis B virus (HBV). Here, show HBV upregulates the expression primary alternatively spliced transcripts their respective isoforms, 1, 2, 5. Since 5 (Sirt2.5) is a catalytically inactive nuclear with spliced-out export signal (NES), speculated its different localization affects activity. The overexpression...
Land-use/land-cover change is an essential factor for understanding the ecological degradation of forests under threat from different climatic and human-mediated activities. This study investigates biodiversity significance Kaziranga Tiger Reserve, situated in Brahmaputra floodplain Assam, India, known its rich flora fauna. Despite importance biodiversity, reserve faces increasing threats habitat fragmentation, human-wildlife conflict, poaching, impacts climate change, necessitating a...
The article’s abstract is not available.
A synergetic approach for the estimation of stable boundary layer height (SBLH) using lidar and microwave radiometer (MWR) data is presented. Vertical variance backscatter signal from a ceilometer used as an indicator aerosol stratification in nocturnal layer. This hypothesis supported by statistical analysis over one month observations. Thermodynamic information MWR-derived potential temperature incorporated coarse estimate SBLH. Data two instruments are adaptively assimilated extended...
Background: We determined the prevalence of antimicrobial resistance (AMR) in polymicrobial pathogens Pakistan. Methods: A total 70,518 clinical samples were collected aseptically and confirmation isolates antibiogram performed by VITEK 2 system. Results: Of samples, 441 (0.62%) with 882 (1.2%) 689 (78.1%) Gram-negative rods (GNRs), 166 (18.8%) Gram-positive cocci 27 (3.1%) Candida albicans. Among GNRs, 28.8% Escherichia coli 25.9% Klebsiella pneumoniae. Majority, 15.1% Pseudomonas...
The Hepatitis B virus (HBV) HBx and HBc proteins play a crucial role in associating with covalently closed circular DNA (cccDNA), the primary factor contributing to intrahepatic viral persistence major obstacle achieving cure for HBV. cccDNA serves as reservoir persistence. Targeting proteins' interaction could potentially limit HBV replication. In this study, we present epitopes identified from global consensus sequences of that have potential serve targets development effective vaccine...
Remote driving (RD) is a critical backup option for an autonomous vehicle when it faces unexpected situation on the road. Fifth generation (5G) mobile communication key enabler of RD providing link between remote operator and vehicle. There are stringent requirements in terms coverage, data rate latency application. In this paper, feasibility study at radio access network level coverage conditions that required application carried out. The considers over three carriers including 2.6 GHz, 5...
We recently reported that the PPIase Par14 and Par17 encoded by PIN4 upregulate HBV replication in an HBx-dependent manner binding to conserved arginine-proline (RP) motifs of HBx. core protein (HBc) has a 133RP134 motif; therefore, we investigated whether Par14/Par17 bind HBc and/or particles. Native agarose gel electrophoresis (NAGE) immunoblotting co-immunoprecipitation were used. Chromatin immunoprecipitation from HBV-infected HepG2-hNTCP-C9 cells was performed. NAGE revealed bound...
ABSTRACT Background: LRIG1 belongs to the family of transmembrane proteins containing leucine-rich repeats. LRIGs are considered as tumor suppressors they negatively regulate receptor tyrosine kinases. The role an EGFR regulator makes it important marker be studied in various epithelial-derived cancers. Methods: expression was determined Erbb2 + cell lines by western blotting, and motility examined migration assay. AKT/GSK3-β/β-catenin pathway presence using blotting. Results: So far, no...
Thalassaemia is an inherited autosomal recessive disorder closely associated with consanguineous marriages. A literature search was conducted aim to investigate thalassemia and Articles were searched from Google Scholar Pubmed information regarding complications, epidemiology of association between marriages thalassemia, which subjected contemplation. Thalassemia carrier rate varies differently in different regions the world. In Indian subcontinent China, Central Asia, South Europe (also...
Abstract COVID-19 pandemic has urged the need of rapid detection SARS-CoV-2 in limited time frame. To cope with current, expanding scenario, accurate diagnosis should be ensured by both national and international health organizations. Sporadic marketing kits raises questions regarding quality control assurance. aim this study was to examine effectiveness nasopharyngeal swab based kits, comparison gold standard USFDA approved triple target real-time polymerase chain reaction. A...