A5083443493- Intraocular Surgery and Lenses
- Ocular Infections and Treatments
- Streptococcal Infections and Treatments
- Laser Applications in Dentistry and Medicine
- Neonatal and Maternal Infections
- Cell Adhesion Molecules Research
- Antimicrobial Resistance in Staphylococcus
- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Immunotherapy and Immune Responses
- Ocular Diseases and Behçet’s Syndrome
- Fungal Infections and Studies
- Acute Myeloid Leukemia Research
- Clusterin in disease pathology
- Photodynamic Therapy Research Studies
- RNA modifications and cancer
- Antifungal resistance and susceptibility
- TGF-β signaling in diseases
- Lung Cancer Diagnosis and Treatment
- Respiratory and Cough-Related Research
- Cancer-related molecular mechanisms research
- Antimicrobial Peptides and Activities
- Nanoplatforms for cancer theranostics
- Immune Cell Function and Interaction
Zhejiang University
2010-2024
Shanghai Institute of Technology
2024
Tianjin Medical University
2010-2023
Tianjin Medical University Eye Hospital
2010-2023
Dana-Farber Cancer Institute
2019-2020
University of Science and Technology Beijing
2020
Boston Children's Hospital
2018-2019
Harvard University
2018-2019
First Affiliated Hospital Zhejiang University
2012-2019
University of Wisconsin–Madison
2010-2016
To compare serum Lutein and Zeaxanthin (L/Z) concentrations between patients with nonproliferative diabetic retinopathy (NDR) normal subjects, to explore the effect of L/Z supplementation on level visual function in NDR patientsSUBJECTS WERE DIVIDED INTO THREE GROUPS: 30 supplied 6mg/d 0.5mg/d for three months (DR Group), without Control Group) subjects (Control Group). Serum were measured by liquid high-resolution chromatography (HPLC). Visual acuity was recorded at baseline, 1 month, 2 3...
The 49-residue functional upstream domain (FUD) of Streptococcus pyogenes F1 adhesin interacts with fibronectin (FN) in a heretofore unknown manner that prevents assembly FN matrix. Biotinylated FUD (b-FUD) bound to adsorbed or its recombinant N-terminal 70-kDa fibrin- and gelatin-binding fragment (70K). Binding was blocked by 70K, but not subfragments 70K. Isothermal titration calorimetry showed binds Kd values 5.2 59 nm soluble 70K FN, respectively. We tested sets mutants epitope-mapped...
Abstract Cigarette smoke (CS), the major cause of chronic obstructive pulmonary disease, contains a variety oxidative components that were implicated in regulation Src homology domain 2-containing protein tyrosine phosphatase 2 (Shp2) activity. However, contribution Shp2 enzyme to disease pathogenesis remains unclear. We investigated role blockading CS-induced inflammation. levels assessed vivo and vitro. Mice (C57BL/6) or epithelial cells (NCI-H292) exposed CS cigarette extract (CSE) induce...
Vitamin D deficiency and vitamin receptor gene polymorphisms are known to be significantly associated with high myopia. Whether this genetic variant may impact primary open-angle glaucoma is largely unknown. This study investigated whether altered in subjects carrying the risk allele, an important factor development of glaucoma. Seventy-three POAG patients 71 age-matched controls from Han population were enrolled. Serum levels 1a, 25-Dihydroxyvitamin D3 measured by enzyme-linked...
Transforming growth factor‑β1 (TGF-β1) is a versatile cytokine. It has context-dependent pro- and anti-cell proliferation functions. Activation of latent TGF-β1 requires release the factor from pro-complexes regulated through TGF-β binding proteins. Two types partners, TGF-β-binding proteins (LTBPs) leucine-rich-repeat-containing protein 32 (LRRC32), have been identified their expression are cell specific. also plays important roles in acute myeloid leukemia (AML) cells. However, LTBPs...
How fibronectin (FN) converts from a compact plasma protein to fibrillar component of extracellular matrix is not understood. "Functional upstream domain" (FUD), polypeptide based on F1 adhesin Streptococcus pyogenes, binds by anti-parallel β-strand addition discontinuous sets N-terminal FN type I modules, (2-5)FNI the fibrin-binding domain and (8-9)FNI gelatin-binding domain. Such binding blocks assembly FN. To learn whether ligation (2-5)FNI, (8-9)FNI, or two in combination important for...
Fibronectin (Fn) is a large glycoprotein present in plasma and extracellular matrix important for many processes. Within Fn the 70 kDa N-terminal region (70k-Fn) involved cell-mediated assembly, process that contributes to embryogenesis, development, platelet thrombus formation. In addition, major human pathogens including Staphlycoccus aureus Streptococcus pyogenes bind 70k-Fn by novel form of protein–protein interaction called β-zipper formation, facilitating bacterial spread colonization....
Abstract Background Accumulating evidence supports the theory that expression of CD127 on CD8 T cells during process antiviral immune response indicates a subset effect successfully develop into fully protective memory. may be used as predictor to evaluate disease status in chronic viral infection. The aim this study was investigate level different subsets cell and explore relationship between memory serum hepatitis B virus (HBV) DNA e antigen (HBeAg) levels patients with (CHB). We also...
Context: Cryptoporus volvatus (Peck) Hubb grows wild in China, and its fruiting bodies have been used traditionally to treat asthma bronchitis.Objectives: This study evaluates the anti-inflammatory effect of polysaccharides (CP) extracted from C. on lipopolysaccharide (LPS)-induced pro-inflammatory factors signaling pathways involved human alveolar epithelial cells.Materials methods: To evaluate effects CP LPS-induced factors, A549 cells were pre-incubated with 1, 10, 100 μg/ml for 1 h then...
To determine the sex hormone levels in serum and aqueous humor patients with age-related cataract corresponding receptors lens epithelial cells (LECs).Research Laboratory, International Intraocular Implant Training Center, Tianjin Medical University, Tianjin, China.Serum were drawn from a control group. Enzyme-linked immunosorbent assay was used to of estradiol, progesterone, testosterone aqueous. The anterior capsules attached LECs obtained during surgery, expressions estrogen receptor,...
Intrinsically disordered sequences within bacterial adhesins bind to E-strands in the β-sheets of multiple FNI modules fibronectin (FN) by anti-parallel β-strand addition, also called tandem β-zipper formation. The FUD segment SfbI Streptococcus pyogenes and Bbk32 BBK32 Borrelia burgdorferi, despite being imbedded different from bacteria, target same modules, 2–5,8–9FNI, N-terminal 70-kDa region (FN70K) FN. To facilitate further comparisons, FUD, Bbk32, two other polypeptides based on that...
To analyze the lab diagnosis and etiology of infectious endophthalmitis.The medical microbial records 36 patients diagnosed with endophthalmitis 8 intraocular lens (IOL)-related inflammation between Nov. 1999 Dec. 2009 were retrospectively reviewed for etiology.The inflammatory cell counts in all aqueous humor specimens from more than IOL-related inflammation. Sixteen samples (44.4%) 11 24 vitreous (45.8%) showed positive results smears; while 17 (47.2%) 15 (62.5%) culture.The count may be...
BACKGROUND: Laser therapy is reported to be clinically effective for improving microcirculation, rheological properties and blood lipid profiles despite the lack of certainty on mechanism.OBJECTIVE: This study intends provide methods drop level hyperlipidemia samples by low-intensity laser irradiation reasoning mechanism.METHODS: Twenty whole high lipids profile are irradiated 405 nm at 12 J/cm 2 twice a day 3 days compared with normal group.Then sample centrifuged obtain result erythrocyte...