A5100707820- Sleep and Wakefulness Research
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Sleep and related disorders
- Circadian rhythm and melatonin
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Tryptophan and brain disorders
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Neuroscience and Neural Engineering
- Epigenetics and DNA Methylation
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Biosensors and Analytical Detection
Columbia University Irving Medical Center
2025
Columbia College
2024-2025
Royal College of Physicians
2024-2025
Columbia University
2021-2025
Salk Institute for Biological Studies
2022-2023
Nanjing University
2022
Capital Medical University
2022
Synchronous neuronal activity is organized into oscillations with various frequency and time domains across different brain areas states. For example, hippocampal theta, gamma sharp wave are critical for memory formation communication between subareas the cortex. In this study, we investigated of dentate gyrus (DG) optical imaging tools during sleep-wake cycles. We found that major glutamatergic cell populations in DG infraslow (0.01 – 0.03 Hz) NREM sleep. Although considered a sparsely...
Synchronous neuronal activity is organized into oscillations with various frequency and time domains across different brain areas states. For example, hippocampal theta, gamma sharp wave are critical for memory formation communication between subareas the cortex. In this study, we investigated of dentate gyrus (DG) optical imaging tools during sleep-wake cycles. We found that major glutamatergic cell populations in DG infraslow (0.01 – 0.03 Hz) NREM sleep. Although considered a sparsely...
Synchronous neuronal activity is organized into oscillations with various frequency and time domains across different brain areas states. For example, hippocampal theta, gamma, sharp wave are critical for memory formation communication between subareas the cortex. In this study, we investigated of dentate gyrus (DG) optical imaging tools during sleep-wake cycles in mice. We found that major glutamatergic cell populations DG infraslow (0.01–0.03 Hz) NREM sleep. Although considered a sparsely...
Understanding the neural mechanisms underlying sleep state transitions is a fundamental goal of neurobiology and important for development new treatments insomnia other disorders. Yet, brain circuits controlling this process remain poorly understood. Here we identify population sleep-active glutamatergic neurons in ventrolateral medulla (VLM) that project to preoptic area (POA), prominent sleep-promoting region, mice. Microendoscopic calcium imaging demonstrate these VLM display increased...
Synchronous neuronal activity is organized into oscillations with various frequency and time domains across different brain areas states. For example, hippocampal theta, gamma sharp wave are critical for memory formation communication between subareas the cortex. In this study, we investigated of dentate gyrus (DG) optical imaging tools during sleep-wake cycles. We found that major glutamatergic cell populations in DG infraslow (0.01 – 0.03 Hz) NREM sleep. Although considered a sparsely...
Synchronous neuronal activity is organized into oscillations with various frequency and time domains across different brain areas states. For example, hippocampal theta, gamma sharp wave are critical for memory formation communication between subareas the cortex. In this study, we investigated of dentate gyrus (DG) electrophysiological optical imaging tools during sleep-wake cycles. We found that major glutamatergic cell populations in DG infraslow (0.01 – 0.03 Hz) NREM sleep. Although...
ABSTRACT Synchronous neuronal activity is organized into oscillations with various frequency and time domains across different brain areas states. For example, hippocampal theta, gamma sharp wave are critical for memory formation communication between subareas the cortex. In this study, we investigated of dentate gyrus (DG) optical imaging tools during sleep-wake cycles. We found that major glutamatergic cell populations in DG infraslow (0.01 – 0.03 Hz) NREM sleep. Although considered a...
The hypothalamic suprachiasmatic nucleus (SCN) is the central circadian pacemaker in vertebrates. SCN receives photic information exclusively through melanopsin-expressing retinal ganglion cells (mRGCs) to synchronize rhythms with environmental light cycles. composed of two major peptidergic neuron types core and shell regions SCN. Determining how mRGCs interact network synaptic connections onto between neurons key understand regulates clock elucidate relevant local circuits within To map...
SUMMARY Sleep is a ubiquitous behavior in animal species. Yet, brain circuits controlling sleep remain poorly understood. Previous studies have identified several structures that promote sleep, but whether these are involved initiation or maintenance remains largely unknown. Here we population of glutamatergic neurons the medulla project to preoptic area (POA), prominent sleep-promoting region. Chemogenetic silencing POA-projecting disrupts transitions from wakefulness Non-Rapid Eye Movement...
Abstract Introduction It has been established that sleep after learning something (“post-learning sleep”) actively consolidates what was learned. Yet, the underlying cellular and molecular mechanisms are undergoing active investigation. The fear conditioning (FC) memory paradigm, in which an animal learns to associate environmental cue aversive foot shock, widely used for While amygdala hippocampus two critical sites processing storing FC memory, how consolidate this during sleep, from both...
Abstract Introduction Alzheimer’s disease (AD) is a debilitating and irreversible neurodegenerative associated with major disruptions to sleep. Recent works point strong bidirectional relationship between loss of slow-wave sleep (SWS), the deepest stage, pathological cognitive features AD. Here, we investigate impacts chronic pharmacological SWS enhancement gaboxadol, delta GABAA receptor agonist, on performance APP/PS1 mouse model Currently, are assessing this intervention Abeta plaque...
Abstract Introduction The function of sleep in memory consolidation has been well established. Hippocampal CA1 and CA3 subregions are thought to be particularly important this process. current working hypothesis postulates that episodic traces captured during waking hours replayed the hippocampal CA1-CA3 areas transferred cortex for long-term storage sleep. Even though sensory spatial information from higher-order cortical such as entorhinal primarily enters hippocampus via dentate gyrus...
Correction for ‘A highly selective AIEgen fluorescent probe visualizing Cys in living cells and C. elegans ’ by Ya-Xi Ye et al. , New J. Chem. 2021, 45 19073–19081.
Abstract The suprachiasmatic nucleus (SCN) in the hypothalamus of vertebrate brain is central pacemaker regulating circadian rhythmicity throughout body. SCN receives photic information through melanopsin-expressing retinal ganglion cells (mRGC) to synchronize body with environmental light cycles. Determining how these inputs fit into network synaptic connections on and between neurons key impelling our understanding regulation clock by unraveling relevant local circuits within SCN. To map...