A5037804993- Trypanosoma species research and implications
- Insect symbiosis and bacterial influences
- Parasitic Infections and Diagnostics
- Helminth infection and control
- Congenital Anomalies and Fetal Surgery
- Research on Leishmaniasis Studies
- Parasitic infections in humans and animals
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Mosquito-borne diseases and control
- Coccidia and coccidiosis research
- Dermatological diseases and infestations
- Parasitic Diseases Research and Treatment
- Rabies epidemiology and control
- Biochemical and Molecular Research
- Vector-borne infectious diseases
- Virology and Viral Diseases
- Amoebic Infections and Treatments
- Zoonotic diseases and public health
- Hemiptera Insect Studies
- Public Health and Social Inequalities
- Insect and Pesticide Research
- Human-Animal Interaction Studies
- Viral Infections and Vectors
- Insects and Parasite Interactions
Universidad Peruana Cayetano Heredia
2010-2020
Universidad Ricardo Palma
2020
Instituto de Medicina Tropical
1989-2019
Universidad de San Martín de Porres
2018
University of Pennsylvania
2014
National University of San Marcos
1998-2014
Johns Hopkins University
2014
Instituto Nacional de Salud
2003-2012
Ministry of Health
2004-2008
Ministerio de Salud
2007
Since ivermectin, a mixture of 2 closely related macrocyclic lactones, has proven highly effective against animal intestinal nematodes, trials were undertaken to determine its efficacy human nematodes. We tested 110 patients with strongyloidiasis and 90 enterobiasis; many had other intercurrent nematode infections. Stool examinations done before after given single dose oral ivermectin capsules (50, 100, 150, or 200 µg/kg body wt); 55 recipients 100 doses received second identical the next...
Populations of the common bed bug, Cimex lectularius , have recently undergone explosive growth. Bed bugs share many important traits with triatomine insects, but it remains unclear whether these similarities include ability to transmit Trypanosoma cruzi etiologic agent Chagas disease. Here, we show efficient and bidirectional transmission T. between hosts in a laboratory environment. Most that fed on experimentally infected mice acquired parasite. A majority previously uninfected became...
We detected 10 protozoan and nine helminth species in surveys of 338 5–15 year‐old Quechua schoolchildren three communities the Asillo zone Puno region, located at a very high altitude 3910 m Peruvian Altiplano. The area proved to be hyperendemic for human fascioliasis with 24.3% overall mean prevalence Fasciola hepatica , local prevalences ranging between 18.8 31.3%, infection intensities up 2496 eggs per gram faeces (epg), 196–350 epg (mean: 279 epg) 96–152 (123 as arithmetic geometric...
Modern cities represent one of the fastest growing ecosystems on planet. Urbanization occurs in stages; each stage characterized by a distinct habitat that may be more or less susceptible to establishment disease vector populations and transmission vector-borne pathogens. We performed longitudinal entomological epidemiological surveys households along 1900 × 125 m transect Arequipa, Peru, major city nearly million inhabitants, which Trypanosoma cruzi , aetiological agent Chagas disease,...
ABSTRACT The serodiagnosis of hydatid disease is a valuable instrument for clinical diagnosis and epidemiological surveillance high-risk populations. In the past decade wealth reports on diagnostic performance numerous antigens have been produced. However, their value has estimated under different conditions, using serum collection, therefore precluding direct comparison. Here we report an unbiased comparison same batch six major E. granulosus antigens, namely, cyst fluid (HCF), native...
Chagas disease is one of the most important neglected tropical diseases in Americas. Vectorborne transmission has been historically rare urban settings. However, marginal communities near city Arequipa, Peru, cycles have become established. We examined history migration and settlement patterns these communities, their connections to transmission.This was a qualitative study that employed focus group discussions in-depth interviews. Five groups 50 interviews were carried out with 94 community...
Abstract Background Human and animal fascioliasis is emerging in many world regions, among which Andean countries constitute the largest regional hot spot Peru country presenting more human endemic areas. A survey was undertaken on lymnaeid snails inhabiting hyperendemic area of Cajamarca, where prevalences are highest known areas a "valley transmission pattern", to establish species present, genetically characterise their populations by comparison with other areas, discuss ones have...
The history of Chagas disease control in Peru and many other nations is marked by scattered poorly documented vector campaigns. complexities human migration sporadic campaigns complicate evaluation the burden dynamics Trypanosoma cruzi transmission.We conducted a cross-sectional serological entomological study to evaluate temporal spatial patterns T. transmission peri-rural region La Joya, Peru. We use multivariate catalytic model Bayesian methods estimate incidence infection over time...
Background Sexual reproduction provides an evolutionary advantageous mechanism that combines favorable mutations have arisen in separate lineages into the same individual. This advantage is especially pronounced microparasites as allelic reassortment among individuals caused by sexual promotes diversity at immune evasion genes within which often essential to evade host systems. Despite these advantages, many eukaryotic exhibit highly-clonal population structures suggesting genetic exchange...
To control and prevent rabies in Latin America, mass dog vaccination campaigns (MDVC) are implemented mainly through fixed-location points: owners have to bring their dogs the points where they receive free of charge. Dog is still endemic some Latin-American countries high overall coverage even distribution vaccinated desired attributes MDVC halt virus transmission. In Arequipa, Peru, we conducted a door-to-door post-campaign survey on >6,000 houses assess placement these two attributes. We...
Echinococcus granulosus, the etiologic agent of cystic echinococcosis (CE) in humans and other animal species, is distributed worldwide. Ten intra-specific variants, or genotypes (G1-G10), have been defined based on genetic diversity. To determine present endemic areas Peru, samples were collected from cattle (44), sheep (41) (14) Junín, Puno Huancavelica, Cusco, Arequipa Ayacucho. DNA was extracted protoscolex and/or germinal layers derived 99 E. granulosus isolates used as templates to...
With increasing urbanization vector-borne diseases are quickly developing in cities, and urban control strategies needed. If streets shown to be barriers disease vectors, city blocks could used as a convenient relevant spatial unit of study control. Unfortunately, existing analysis tools do not allow for assessment the impact an grid on presence agents. Here, we first propose method test significance vector infestation based decomposition Moran's autocorrelation index; second, develop...
SYNOPSIS. The Tulahuen and Peruvian strains of Trypanosoma cruzi have been compared as to their ability metabolize C 14 ‐glucose uniformly labeled, or labeled in carbons 1, 2, 6. Most the radioactivity from glucose is incorporated into organic acids both strains, but significant also recovered CO 2 . strain has a slightly higher rate consumption, incorporation glucose‐C higher. More proteins strain, total fairly similar cases. On basis rates O production specifically 6, well glycerol...
Aims Preliminary results indicate higher absorption of triclabendazole (TCBZ) administered postprandially. Therefore, the influence food on pharmacokinetics TCBZ and its active sulphoxide (TCBZ‐SO) sulphone (TCBZ‐SO2) metabolites was investigated. Methods Two single doses (10 mg kg −1 ) were to 20 patients with fascioliasis. Ten first given drug after a high energy breakfast then, 48 h later, an overnight fast. The other 10 received in fasting state breakfast. A low served 2 administration...
Abstract Background Interruption of vector-borne transmission Trypanosoma cruzi remains an unrealized objective in many Latin American countries. The task vector control is complicated by the emergence insects urban areas. Methods Utilizing data from a large-scale program Arequipa, Peru, we explored spatial patterns infestation Triatoma infestans and peri-urban landscape. Multilevel logistic regression was utilized to assess associations between household household- locality-level...
Abstract Chagas disease vector control campaigns are being conducted in Latin America, but little is known about medium-term or long-term effectiveness of these efforts, especially urban areas. After analyzing entomologic data for 56,491 households during the treatment phase a Triatoma infestans bug campaign Arequipa, Peru, 2003–2011, we estimated that 97.1% residual infestations attributable to untreated households. Multivariate models surveillance obtained 2009–2012 confirm...
Fasciola hepatica adult worm cysteine proteinases were active-site, affinity radio-labeled with benzyloxicarbonyl-L-tyrosine-L-alanine diazomethylketone (Z-Tyr125I-Ala-CHN2). Sera from patients fascioliasis and rabbits experimentally infected F. immunoprecipitated the radiolabeled parasite in immunoelectrophoresis assays. Two purified antigens identified as part of complex mosaic by sera patients. These (Fas1 Fas2) have been shown to be an important Fharc2 precipitin band used for serologic...
The epimastigotes of Trypanosoma cruzi hydroxylate drugs at substantial rates. activity, which is the mixed-function oxidase type, increased by phenobarbital and inhibited CO, SKF 525-A, metyrapone. hydroxylation paralleled increases in free membrane-bound ribosomes.
The identification of the genotypes Echinococcus granulosus present in livestock and wild animals within regions endemic for cystic echinococcosis (CE) is epidemiologically important. Individual strains display different biological characteristics that contribute to outbreaks CE must be taken into account design intervention programs. In this study, samples hydatid cysts due E. were collected from alpacas (4) Puno pigs (8) Ayacucho Peru, an region CE. Polymerase chain reaction amplification...