A5010362200- Radical Photochemical Reactions
- Oxidative Organic Chemistry Reactions
- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Advanced Photocatalysis Techniques
- Innovative Microfluidic and Catalytic Techniques Innovation
- Coordination Chemistry and Organometallics
- Asymmetric Hydrogenation and Catalysis
- Banana Cultivation and Research
- Synthesis and Catalytic Reactions
- Fluorine in Organic Chemistry
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Reactions
- Traditional and Medicinal Uses of Annonaceae
- Piperaceae Chemical and Biological Studies
University of Bristol
2023-2025
University of Regensburg
2020-2024
University of Santo Tomas
2019
Abstract Photocatalysis is a powerful tool to assemble diverse chemical scaffolds, yet bottleneck on its further development the understanding of multitude possible pathways when practitioners rely only oversimplified thermodynamic and optical factors. Recently, there growing number studies in field that exploit, inter alia , kinetic parameters organophotocatalysts are synthetically more programmable terms their redox states opportunities for aggregation with target substrate. Non‐covalent...
We report an organophotocatalytic, N-CH
Dichotomous thinking dominates the field of synthetic photochemistry – either a reaction needs photocatalyst or not. Herein, we report identification photoredox autocatalytic pathway, an alternative to existing mechanistic paradigms, access cyclic biaryl sulfonamides (BASNs). This does not require exogenous catalyst as visible light absorbing deprotonated product itself, with potent excited state reductive power, acts for its own synthesis. finding implicated BASN novel organophotocatalyst...
Dichotomous thinking dominates the field of synthetic photochemistry – either a reaction needs photocatalyst or not. Herein, we report identification photoredox autocatalytic pathway, an alternative to existing mechanistic paradigms, access cyclic biaryl sulfonamides (BASNs). This does not require exogenous catalyst as visible light absorbing deprotonated product itself, with potent excited state reductive power, acts for its own synthesis. finding implicated BASN novel organophotocatalyst...
Of the methods for direct fluorination of unactivated C(sp3)-H bonds, photosensitization SelectFluor is a promising approach. Although many substrates can be activated with photosensitizing catalysts, issues remain that hamper complex molecules. Alcohol- or amine-containing functional groups are not tolerated, regioselectivity follows factors endogenous to substrate and cannot influenced by catalyst, reactions highly air-sensitive. We report benzoyl serve as efficient photosensitizers which,...
Dichotomous thinking dominates the field of synthetic photochemistry – either a reaction needs photocatalyst or not. Herein, we report discovery photoredox autocatalytic pathway, third mechanistic paradigm that is thus far overlooked, to access cyclic biaryl sulfonamides (BASNs). This does not require exogenous catalyst as visible light absorbing deprotonated product itself, with potent excited state reductive power, acts for its own synthesis. finding implicated BASN novel...
Background: Electrophilic compounds bearing Michael acceptors present great promise in anticancer drug discovery. Methods: Drawing inspirations from cytotoxic Piper lactam alkaloids, twelve N-acylated butyro- and valerolactams were prepared evaluated for antiproliferative activities against the normal human umbilical vein endothelial cells (HUVEC), chronic myeloid leukemia (K- 562), Henrietta Lacks (HeLa) used as model cell lines. Molecular docking of bioactive derivatives was performed...
We report an organophotocatalytic, N-CH3-selective oxidation of trialkylamines in continuous flow. Based on the 9,10-dicyanoanthracene (DCA) core, a new catalyst (DCAS) was designed with solubilizing groups for processing flow which allowed harnessing O2 as benign reagent late-stage photocatalytic N-CH3 natural products and active pharmaceutical ingredients. These substrates bear functional are not tolerated by previous methods. The organophotocatalytic process benefited from parameters,...
We report an organophotocatalytic, N-CH3-selective oxidation of trialkylamines in continuous flow. Based on the 9,10-dicyanoanthracene (DCA) core, a new catalyst (DCAS) was designed with solubilizing groups for processing flow which allowed harnessing O2 as benign reagent late-stage photocatalytic N-CH3 natural products and active pharmaceutical ingredients. These substrates bear functional are not tolerated by previous methods. The organophotocatalytic process benefited from parameters,...