The Non-Fungible Token (NFT) market is mushrooming in recent years. concept of NFT originally comes from a token standard Ethereum, aiming to distinguish each with distinguishable signs. This type can be bound virtual/digital properties as their unique identifications. With NFTs, all marked freely traded customized values according ages, rarity, liquidity, etc. It has greatly stimulated the prosperity decentralized application (DApp) market. At time writing (May 2021), total money used on...

Web3 is the most hyped concept from 2020 to date, greatly motivating prosperity of Internet Value and Metaverse. However, no solid evidence stipulates exact definition, criterion, or standard in sense such a buzzword. To fill gap, we aim clarify term this work. We narrow down connotation by separating it high-level controversy argues and, instead, focusing on its protocol, architecture, evaluation perspective blockchain fields. Specifically, have identified all potential architectural design...

As the most common cause of cancer death in women, pathogenesis breast still remains unclear. Here, we reported a long non-coding RNA (lncRNA), HOTTIP (HOXA transcript at distal tip), that may play an important role cancer. Using gain-and-loss-of experiments vitro and vivo, observed marked upregulation HOTTIP/HOXA11 cell line, MCF-7, downregulation or HOXA11, which might inhibit proliferation migration but promote apoptosis MCF-7 cells. In addition, by further rescue with HOXA11...

Formin-like 3 (FMNL3) plays a crucial role in cytoskeletal mediation and is potentially biomarker for cell migration; however, its cancer metastasis remains unknown. In this study, we found elevated FMNL3 protein expression clinical nasopharyngeal carcinoma (NPC) tissues. positively correlated to the stage, T (tumour), N (lymph node metastasis) M (distant classification of NPC patients. Moreover, Vimentin negatively E-cadherin samples. vitro experiments showed that was inversely related...

The blockchain-based smart contract lacks privacy, since the state and instruction code are exposed to public. Combining smart-contract execution with Trusted Execution Environments provides an efficient solution, called TEE-assisted contracts (TCSC), for protecting confidentiality of states. However, combination approaches varied, a systematic study is absent. Newly released systems may fail draw upon experience learned from existing protocols, such as repeating known design mistakes or...

Hypoxia is beneficial for the differentiation of stem cells transplanted myocardial injury, but mechanisms underlying this benefit remain unsolved. Here, we report impact hypoxia-induced Jagged1 expression in cardiomyocytes (CMs) driving cardiac (CSCs). Forced hypoxia-inducible factor 1α (HIF-1α) and physical hypoxia (5% O2) treatment could induce neonatal rat CMs. Pharmacological inhibition HIF-1α by YC-1 attenuated hypoxia-promoted An ERK inhibitor (PD98059), not inhibitors JNK (SP600125),...

Serine/threonine kinase proviral integration site for Moloney murine leukemia virus 1 (Pim-1) plays an essential role in arterial wall cell proliferation and associated vascular diseases, including pulmonary hypertension aortic neointima formation. Here we tested a of Pim-1 high-glucose (HG)-mediated smooth muscle (VSMC) proliferation. proliferating nuclear antigen (PCNA) expression levels samples from streptozotocin-induced hyperglycemia rats were increased, compared with their weak...

Proof of Authority (PoA) is a type permissioned consensus algorithm with fixed committee. PoA has been widely adopted by communities and industries due to its better performance faster finality. In this paper, we explore the unfairness issue existing in current implementations. We have investigated 2,500+ wild projects selected 10+ as our main focus (covering Ethereum, Binance smart chain, etc.). identified two types order manipulation attacks separately break transaction-level (a.k.a....

Secreted frizzled-related protein 1 (SFRP1) is a member of the SFRPs family that modulates Wnt signal transduction pathway. Recent studies have showed down-regulation SFRP1 expression in colorectal cancer (CRC). We aimed to evaluate effect on proliferation, migration, invasion and apoptosis CRC cells vitro.We used real-time fluorescence quantification (RT-PCR) Western blotting detect CRC, pericarcinomatous tissues cell lines. assessed influence overexpression knockdown invasion, apoptosis,...

A large number of consensus algorithms have been proposed. However, the requirement strict consistency limits their wide adoption, especially in high-performance required systems. In this paper, we propose a weak algorithm that only maintains relative positions between messages. We apply to construct blockchain system, called \textit{Sphinx}. implement system with 32k+ lines code including all components like consensus/P2P/ledger/etc. The evaluations show Sphinx can reach peak throughput 43k...

To explore the role of proto-oncogene Pim-1 in proliferation and migration nasopharyngeal carcinoma (NPC) cells. expressions NPC cell lines CNE1, CNE1-GL, CNE-2Z C666-1 were examined by RT-PCR, western blotting immunoflucesence, respectively. After CNE1-GL cells treated with different concentrations special inhibitor, quercetagetin, viability, colony formation rate ability analyzed. expression was negative well-differentiated CNE1 cells, whereas expressed weakly positive poor-differentiated...

Abstract Background Special AT rich sequence binding protein 1 (SATB1) plays a crucial role in the biology of various types human cancer. However, SATB1 nasopharyngeal carcinoma (NPC) remains unknown. In present study, we sought to investigate contribution aberrant expression progression NPC and its association with Epstein Barr virus (EBV)-encoded latent membrane (LMP-1). Methods Immunohistochemical analysis was performed detect LMP-1 clinical samples, patient clinicopathological...

NEO is one of the top public chains worldwide. It adopts a new consensus algorithm called delegated Byzantine Fault Tolerance (dBFT). In this article, we formalize dBFT via state machine replication model and point out its potential issues. Our theoretical analysis indicates that could guarantee neither liveness nor safety , even if number nodes no more than threshold, which has contradicted established security claim. Then, identify two attacks successfully simulate them. Finally, provide...

Pancreatic cancer is the fourth leading cause of cancer-related death in both men and women worldwide. The 5-year relative survival rate for pancreatic ductal adenocarcinoma (PDAC) 10%, which lowest among all cancers. This study aimed to find more effective targets improve diagnosis, prognostic prediction, treatment PDAC.

Smart contracts have recently been adopted by many security protocols. However, existing studies lack satisfactory theoretical support on how benefit This paper aims to give a systematic analysis of smart contract (SC)-based protocols fulfill the gap unclear arguments and statements. We firstly investigate \textit{state art studies} establish formalized model with well-defined syntax assumptions. Then, we apply our formal framework two concrete instructions explore corresponding advantages...

Proof of Authority (PoA) is a type permissioned consensus algorithm with fixed committee. PoA has been widely adopted by communities and industries due to its better performance faster finality. In this paper, we explore the \textit{unfairness} issue existing in current implementations. We have investigated 2,500+ \textit{in wild} projects selected 10+ as our main focus (covering Ethereum, Binance smart chain, etc.). identified two types order manipulation attacks separately break...

As blockchain-based commercial projects and startups flourish, efficiency becomes one of the critical metrics in designing blockchain systems. Due to its high efficiency, Proof Authority (PoA) Aura has become most widely adopted consensus solutions for blockchains. Our research finds over 4,000 have used variants. In this paper, we provide a rigorous analysis Aura. We propose three types time-manipulation attacks, where malicious leader simply needs modify timestamp proposed block or delay...

Nasopharyngeal carcinoma (NPC) is a common malignancy of the head and neck. The aim present study was to conduct an integrated bioinformatics analysis differentially expressed genes (DEGs) explore molecular mechanisms NPC. Two profiling datasets, GSE12452 GSE34573, were downloaded from Gene Expression Omnibus database included 44 NPC specimens 13 normal nasopharyngeal tissues. R software used identify DEGs between Distributions in chromosomes explored based on annotation file CYTOBAND DAVID....

Background: Since anaplastic thyroid carcinoma (ATC) has rapid progression and a poor outcome, identification of the key genes underlying mechanisms ATC is required. Methods: Gene expression profiles GSE29265 GSE33630 were available from Expression Omnibus database. The two profile datasets included 19 tissues, 55 normal tissues 59 papillary cancer (PTC) tissues. Differentially expressed (DEGs) between as well PTC identified using GEO2R tool. Common DEGs selected via Venn software online....

Blockchain-based cryptocurrencies, facilitating the convenience of payment by providing a decentralized online solution, have not been widely adopted so far due to slow confirmation transactions. Offline delegation offers an efficient way exchange coins. However, in such approach, coins that delegated confront risk being spent twice since delegator's behaviour cannot be restricted easily on account absence effective supervision. Even if third party can regarded as judge between delegator and...