A5016936713- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- COVID-19 and healthcare impacts
- Bayesian Methods and Mixture Models
- Markov Chains and Monte Carlo Methods
- Forecasting Techniques and Applications
- Respiratory Support and Mechanisms
- Poverty, Education, and Child Welfare
- Hormonal Regulation and Hypertension
- Monetary Policy and Economic Impact
- Mathematical Approximation and Integration
- Geophysics and Gravity Measurements
- Direction-of-Arrival Estimation Techniques
- Advanced Wireless Communication Techniques
- Stock Market Forecasting Methods
- Millimeter-Wave Propagation and Modeling
- Mathematical functions and polynomials
- Financial Literacy, Pension, Retirement Analysis
- Healthcare cost, quality, practices
- Statistical Distribution Estimation and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Geriatric Care and Nursing Homes
- Statistical and numerical algorithms
- School Choice and Performance
University College London
2024-2025
Imperial College Healthcare NHS Trust
2024-2025
MRC Biostatistics Unit
2019-2024
MRC Clinical Trials Unit at UCL
2024
Royal Statistical Society
2024
University of Cambridge
2019-2022
London School of Hygiene & Tropical Medicine
2022
University of Manchester
2017-2020
Vrije Universiteit Amsterdam
2019
Amsterdam UMC Location Vrije Universiteit Amsterdam
2017
Objectives: A conservative oxygenation strategy is recommended in adult and pediatric guidelines for the management of acute respiratory distress syndrome to reduce iatrogenic lung damage. In recently reported Oxy-PICU trial, targeting peripheral oxygen saturations (Sp o 2 ) between 88% 92% was associated with a shorter duration organ support greater survival, compared Sp than 94%, mechanically ventilated children following unplanned admission PICU. We investigated whether this benefit those...
Abstract INTRODUCTION Trials of effectiveness treatment options for depression in dementia are an important priority. METHODS Randomized controlled trial to assess adapted Problem Adaptation Therapy (PATH) mild/moderate caused by Alzheimer's disease. RESULTS Three hundred thirty‐six participants with mild or moderate dementia, >7 on Cornell Scale Depression Dementia (CSDD), randomized PATH as usual. Mean age 77.0 years, 39.0% males, mean Mini‐Mental State Examination 21.6, CSDD 12.9. For...
A conservative oxygenation strategy, targeting peripheral oxygen saturations (Sp o2 ) between 88% and 92% in mechanically ventilated children PICU, was associated with a shorter duration of organ support greater survival compared Sp than 94% our recent Oxy-PICU trial. monitors may overestimate arterial saturation (Sa patients higher levels skin pigmentation those less pigmentation. We investigated if ethnicity changes distributions F io2 outcome.
In this paper we estimate the impact of road development on household welfare in rural Papua New Guinea over period between 1996 and 2010, using two cross-sectional surveys corresponding maps. To deal with endogenous placement infrastructure programs employ a correlated random effects model that corrects for location-specific changes quality. We also use newly developed quantile regression method to investigate whether works are pro-poor. Estimates show investments sealing roads nearest...
Objectives Provision of personalised care planning is a national priority for people with dementia. Research suggests lack quality and consistency plans reviews. The PriDem model was developed to deliver feasible acceptable primary care-based postdiagnostic dementia care. We aimed increase the adoption dementia, exploring implementation facilitators barriers. Design Mixed-method feasibility study. Setting Seven general practices from four networks (PCNs) in Northeast Southeast England....
Objectives To evaluate the feasibility and acceptability of a primary care-based intervention for improving post-diagnostic dementia care support (PriDem), implementation study procedures. Design A non-randomised, mixed methods, study. Setting Seven general practices from four networks (PCNs) in Northeast Southeast England. Participants We aimed to recruit 80 people with (PWD) 66 carers Intervention Clinical Dementia Leads delivered 12-month participating PCNs, develop systems, build staff...
Previous studies have reported conflicting findings regarding aldosterone levels in patients hospitalised with COVID-19. We therefore used the gold-standard technique of liquid chromatography-tandem mass spectrometry (LCMSMS) to address this uncertainty.
Abstract The interaction of the two drugs warfarin and phenylbutazone has previously been considered as a time‐optimal control problem with state inequality constraints. We include bounds for show that necessary optimality conditions junction bounded variables lead to boundary value problems switching conditions. A special version multiple‐shooting algorithm is employed solving different types problems. structure optimal determined range parameters in constraint. Owing control, space...
Abstract The Rosenbrock function is a ubiquitous benchmark problem in numerical optimization, and variants have been proposed to test the performance of Markov chain Monte Carlo algorithms on distributions with curved narrow shape. In this work we discuss distribution advantages limitations its current n ‐dimensional extensions. We then propose new extension arbitrary dimensions called Hybrid distribution, which addresses all that affect composed conditional normal kernels arranged such way...
The first statistical analysis of maximum rainfall in Zimbabwe is provided. data are from 103 stations spread across the different climatic regions Zimbabwe. More than 90% had at least 50 years data. generalized extreme value distribution was fitted to by method likelihood. Probability plots, quantile plots and Kolmogorov-Smirnov tests showed that provided an adequate fit for all stations. vast majority do not exhibit significant trends rainfall. Twelve negative three positive Estimates...
Summary The Rayleigh distribution is of paramount importance in signal processing and many other areas, yet an expression for random variables arbitrary dimensions has remained elusive. In this note, we generalise the results Beard Tekinay quadrivariate to cases unconstrained order provide a simple algorithm evaluation. assumptions cross‐correlation between in‐phase quadrature, as well nonsingularity covariance matrix, are retained throughout our computations.
Background Depression is common in people with dementia, and negatively affects quality of life. Aims This paper aims to evaluate the cost-effectiveness an intervention for depression mild moderate dementia caused by Alzheimer's disease over 12 months (PATHFINDER trial), from both health social care societal perspectives. Method A total 336 participants were randomised receive adapted PATH addition treatment as usual (TAU) ( n = 168) or TAU alone 168). Health resource use collected Client...
The characteristic function of the lognormal distribution is interest in a number scientific fields yet an analytic solution remains elusive, making reliable and efficient approximations necessary. In this article, we build on results N. C. Beaulieu A. Saberali ‘New to function’, by introducing Taylor- Bessel function-based partial expansion integrand Chebyshev quadrature approach. Through computer simulations show that Taylor accurate for all commonly computed values, specify range values...
<b>Background</b>: Respiratory diseases can often be long-term afflictions and may severely affect a patient's quality of life. Though treatments are available, the underlying mechanisms symptoms not well understood. <b>Aim</b>: Develop validate algorithms able to distinguish patients with different respiratory diseases, based on 24h cough sound recording data. <b>Methods</b>: With appropriate equipment, accurate recordings patients' coughing sequences created relative ease. Based this data...
Objective Previous studies have reported conflicting findings regarding aldosterone levels in patients hospitalised with COVID-19. We therefore used the gold-standard technique of liquid chromatography tandem mass-spectrometry (LCMSMS) to address this uncertainty. Design All admitted Cambridge University Hospitals COVID-19 between March 10, 2020 and May 13, 2021, whom a stored blood sample was available for analysis, were eligible inclusion. Methods Aldosterone measured by LCMSMS...
Objectives To develop a disease stratification model for COVID-19 that updates according to changes in patient’s condition while hospital facilitate patient management and resource allocation. Design In this retrospective cohort study, we adopted landmarking approach dynamic prediction of all-cause in-hospital mortality over the next 48 hours. We accounted informative predictor missingness selected predictors using penalised regression. Setting All data used study were obtained from single...