A5007846566- Vector-borne infectious diseases
- Toxin Mechanisms and Immunotoxins
- Insect and Pesticide Research
- Insect symbiosis and bacterial influences
- Advanced Biosensing Techniques and Applications
- Studies on Chitinases and Chitosanases
- Invertebrate Immune Response Mechanisms
- Antimicrobial Peptides and Activities
- Vector-Borne Animal Diseases
- Advanced Proteomics Techniques and Applications
- Immunotherapy and Immune Responses
- Transgenic Plants and Applications
- Erythrocyte Function and Pathophysiology
- Pancreatic and Hepatic Oncology Research
- Phagocytosis and Immune Regulation
- Insect Pest Control Strategies
- Galectins and Cancer Biology
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
University of South Bohemia in České Budějovice
2019-2023
Czech Academy of Sciences, Biology Centre
2022-2023
Institute of Parasitology
2022-2023
Serpins are widely distributed and functionally diverse inhibitors of serine proteases. Ticks secrete serpins with anti-coagulation, anti-inflammatory, immunomodulatory activities via their saliva into the feeding cavity to modulate host’s hemostatic immune reaction initiated by insertion tick’s mouthparts skin. The suppression response not only allows ticks feed on a host for several days but also creates favorable conditions transmission tick-borne pathogens. Herein we present functional...
Tick saliva is a rich source of antihemostatic, anti-inflammatory, and immunomodulatory molecules that actively help the tick to finish its blood meal. Moreover, these facilitate transmission tick-borne pathogens. Here we present functional structural characterization Iripin-8, salivary serpin from Ixodes ricinus, European vector encephalitis Lyme disease. Iripin-8 displayed blood-meal-induced mRNA expression peaked in nymphs glands adult females. inhibited multiple proteases involved...
Tick saliva is a rich source of pharmacologically and immunologically active molecules. These salivary components are indispensable for successful blood feeding on vertebrate hosts believed to facilitate the transmission tick-borne pathogens. Here we present functional structural characterization Iripin-3, protein expressed in glands tick Ixodes ricinus , European vector encephalitis Lyme disease. Belonging serpin superfamily protease inhibitors, Iripin-3 strongly inhibited proteolytic...
In vitro models are often used for studying macrophage functions, including the process of phagocytosis. The application primary macrophages has limitations associated with individual characteristics animals, which can lead to insufficient standardization and higher variability obtained results. Immortalized cell lines do not have these disadvantages, but their responses various signals differ from those living organism. present study, a comparative proteomic analysis immortalized PMJ2-R...
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