A5013504737- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Nutrition and Health in Aging
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Eosinophilic Esophagitis
- Frailty in Older Adults
- Inflammatory Bowel Disease
- Advanced X-ray and CT Imaging
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Lung Cancer Research Studies
- Microscopic Colitis
- Chemotherapy-induced cardiotoxicity and mitigation
- Brain Metastases and Treatment
- Head and Neck Cancer Studies
- Peptidase Inhibition and Analysis
- Medical Imaging and Pathology Studies
- Electronic Health Records Systems
- Advanced Radiotherapy Techniques
- Circular RNAs in diseases
- Cancer Treatment and Pharmacology
- Microwave-Assisted Synthesis and Applications
- Myasthenia Gravis and Thymoma
Zuyderland Medisch Centrum
2023-2025
Maastricht University
2017-2022
Maastricht University Medical Centre
2018-2020
Tight control of disease activity, medication side effects, and adherence are crucial to prevent complications improve quality life in patients with inflammatory bowel (IBD). The chronic nature increasing incidence IBD demand health care innovations guarantee future high-quality care. Previous research proved that integrated by telemedicine can outcomes diseases. Currently available tools focus on specific patient subgroups. Therefore, we aimed (1) develop a system suitable for all everyday...
Abstract Background Cachexia, highly prevalent in patients with non‐small cell lung cancer (NSCLC), impairs quality of life and is associated reduced tolerance responsiveness to therapy decreased survival. MicroRNAs (miRNAs) are small non‐coding RNAs that play a central role post‐transcriptional gene regulation. Changes intramuscular levels miRNAs have been implicated muscle wasting conditions. Here, we aimed identify differentially expressed skeletal cachectic increase our understanding...
Abstract Background It is not well known to what extent effectiveness of treatment with immune checkpoint inhibitors in stage IV non‐small‐cell lung cancer (NSCLC) influenced by weight loss and changes body composition. Therefore, the goal this study was evaluate composition relation early change overall survival (OS) NSCLC patients treated second‐line nivolumab. Methods All NSCLC, who were nivolumab between June 2015 December 2018 at Maastricht University Medical Center, evaluated. Skeletal...
The impact of an immune checkpoint inhibitor (ICI)-based systemic treatment strategy with or without local radical (LRT) on outcomes for patients NSCLC and synchronous oligometastatic disease (sOMD) is unknown. Multicenter retrospective study including adequately staged patients, sOMD (maximum five metastases in three organs [European Organization Research Treatment Cancer definition]) between January 1, 2015 December 31, 2022, treated a first-line ICI-based versus chemotherapy-only regimen....
Abstract Background Brain metastases (BM) frequently occur in patients with non-small cell lung cancer (NSCLC) actionable genomic alterations (AGA). Targeted therapies (TTs) improve outcomes, but differences BM screening and eligibility criteria across trials make comparisons challenging. While stage IV NSCLC guidelines recommend screening, it is not mandatory, imaging techniques vary. Methods Registrational phase II/III of FDA/EMA-approved TTs for advanced AGA, published since 2012, were...
To evaluate the relationship between early changes in muscle and adipose tissue during chemotherapy overall survival (OS) stage IV non-small cell lung cancer (NSCLC).In this post-hoc analysis of first line NVALT12 trial (NCT01171170) NSCLC, skeletal (SM), radiation attenuation (RA), subcutaneous (SAT) visceral (VAT) were assessed at third lumbar level on CT-images obtained before initiation shortly after administration second cycle. The contribution different body compartments to was...
Patient-reported outcome measures [PROMs] assessing inflammatory bowel disease [IBD] activity are of interest for monitoring in clinical practice, telemedicine systems, or trials. Different PROMs follow-up available; however, none was developed with endoscopy as gold standard. The objective this study to develop and validate a PROM predict endoscopic activity, following the recommendations Food Drug Administration.During development, 178 IBD patients undergoing colonoscopy were asked fill...
Muscle depletion negatively impacts treatment efficacy and survival rates in cancer. Prevention timely of muscle loss require prediction patients at risk. We aimed to investigate the potential skeletal radiomic features predict future loss.A total 116 with stage IV non-small cell lung cancer included a randomised controlled trial (NCT01171170) studying effect nitroglycerin added paclitaxel-carboplatin-bevacizumab were enrolled. In this post hoc analysis, cross-sectional area extracted from...
Background: Computed tomography (CT) is increasingly used in clinical research for single-slice assessment of muscle mass to correlate with outcome and evaluate treatment efficacy. The third lumbar level (L3) considered as reference muscle, but chest scans generally do not reach beyond the first (L1). This study investigates if pectoralis L1 are appropriate alternatives L3. Methods: CT 115 stage IV non-small cell lung cancer patients were analyzed before during tumor therapy. Skeletal...
Background: Cancer cachexia is highly prevalent in advanced non-small cell lung cancer (NSCLC) and locally head neck squamous carcinoma (LAHNSCC), compromises treatment tolerance overall survival (OS). NSCLC LAHNSCC patients share similar risk factors, receive comparable anti-cancer regimens. The aim of this study was to determine the predictive value body composition assessed by bioelectrical impedance analysis (BIA) handgrip strength (HGS) (baseline early changes during therapy) on OS...
To identify clinical risk factors, including gross tumor volume (GTV) and radiomics features, for developing brain metastases (BM) in patients with radically treated stage III non-small cell lung cancer (NSCLC).Clinical data planning CT scans thoracic radiotherapy were retrieved from NSCLC. Radiomics features extracted the GTV, primary (GTVp), involved lymph nodes (GTVn), separately. Competing analysis was used to develop models (clinical, radiomics, combined model). LASSO regression...
Proton radiotherapy (PT) is a promising but more expensive strategy than photon (XRT) for the treatment of non-small cell lung cancer (NSCLC). PT probably not cost-effective all patients. Therefore, patients can be selected using normal tissue complication probability (NTCP) models with predefined criteria. This study aimed to explore cost-effectiveness three strategies stage III NSCLC: 1. (XRTAll); 2. (PTAll); 3. (PTIndividualized).A decision-analytical model was constructed estimate and...
Objectives Dyspnoea is one of the symptoms frequently encountered after treatment with chemoradiotherapy (CRT) in stage III non-small cell lung cancer (NSCLC). Long-term data on mild to moderately severe cardiac events as underlying cause dyspnoea patients NSCLC are lacking. Therefore, incidence new events, a common terminology criteria for adverse (CTCAE) score ≥2 within 5 years diagnosis, were analysed. Design Retrospective multicentre cohort study treated CRT from 2006 2013. The medical...
Among patients with advanced NSCLC, there is a group of synchronous oligometastatic disease (sOMD), defined as limited number metastases detected at the time diagnosis. As cachexia and sarcopenia are linked to poor survival, incorporating this information could assist clinicians in determining whether radical treatment should be administered. In retrospective multicenter study, including all adequately staged (FDG-PET, brain imaging) sOMD according EORTC definition, we aimed assess...