A5031911194- Pregnancy and preeclampsia studies
- Neonatal Respiratory Health Research
- Blood properties and coagulation
- Birth, Development, and Health
- Asthma and respiratory diseases
- Renal and related cancers
- Maternal and fetal healthcare
- Lattice Boltzmann Simulation Studies
- Water-Energy-Food Nexus Studies
- Cardiovascular Health and Disease Prevention
- Erythrocyte Function and Pathophysiology
- 3D Printing in Biomedical Research
- Inhalation and Respiratory Drug Delivery
- Advanced Mathematical Modeling in Engineering
- Artificial Intelligence in Healthcare
- Machine Learning in Healthcare
- Prenatal Screening and Diagnostics
- Gestational Diabetes Research and Management
- Electrical and Bioimpedance Tomography
- Point processes and geometric inequalities
- Allergic Rhinitis and Sensitization
- Receptor Mechanisms and Signaling
- MRI in cancer diagnosis
- Heat and Mass Transfer in Porous Media
- Autopsy Techniques and Outcomes
University of Manchester
2016-2024
St Mary's Hospital
2020-2021
Manchester Academic Health Science Centre
2018-2019
St Mary's Hospital
2018
University of Nottingham
2009-2016
Applied Mathematics (United States)
2008
The placenta is a multi-functional organ that exchanges blood gases and nutrients between mother her developing fetus. In humans, fetal flows through intricate networks of vessels confined within villous trees, the branches which are bathed in pools maternal blood. Fluid mechanics transport processes play central role understanding how these elaborate structures contribute to function placenta, their disorganization may lead disease. Recent advances imaging computation have spurred...
Bronchial thermoplasty is a treatment for asthma. It currently unclear whether its histopathological impact sufficiently explained by the proportion of airway wall that exposed to temperatures necessary affect cell survival.Airway smooth muscle and bronchial epithelial cells were media (37-70°C) 10 s mimic thermoplasty. In silico we developed mathematical model heat distribution post-thermoplasty. vivo determined mass integrity pre- post-thermoplasty in 14 patients with severe asthma.In...
During pregnancy, oxygen diffuses from maternal to fetal blood through villous trees in the placenta. In this paper, we simulate flow and transfer feto-placental capillaries by converting three-dimensional representations of capillary surfaces, reconstructed confocal laser scanning microscopy, finite-element meshes, calculating values vascular resistance total transfer. The relationship between rate pressure drop is shown be captured across a wide range drops physical scaling laws an upper...
Across mammalian species, solute exchange takes place in complex microvascular networks. In the human placenta, primary units are terminal villi that contain disordered networks of fetal capillaries and surrounded externally by maternal blood. Here we show how irregular internal structure a villus determines its capacity for wide range solutes. Distilling geometric features into three scalar parameters, obtained from image analysis computational fluid dynamics, capture archetypal...
Multi-scale structural assessment of biological soft tissue is challenging but essential to gain insight into structure–function relationships tissue/organ. Using the human placenta as an example, this study brings together sophisticated sample preparation protocols, advanced imaging and robust, validated machine-learning segmentation techniques provide first massively multi-scale multi-domain information that enables detailed morphological functional analyses both maternal fetal placental...
The umbilical cord plays a critical role in delivering nutrients and oxygen from the placenta to fetus through vein, while two arteries carry deoxygenated blood with waste products back placenta. Although solute exchange has been extensively studied, within tissue not investigated. Here, we explore hypothesis that coiled structure of could strengthen diffusive coupling between resulting functional shunt. We calculate diffusion solutes, such as oxygen, heat quantify how this shunt is affected...
The placenta is an essential component of the life-support system for developing foetus, enabling nutrients and waste to be exchanged between foetal maternal circulations. Maternal blood flows densely packed branches villous trees, within which are vessels. Here, we explore some challenges in modelling haemodynamic transport using homogenization approaches. We first show how two measures can used estimate minimum distance over distribution appears statistically homogeneous. then analyse a...
We design a suspension of ultra-soft, deflated PDMS microcapsules, which mimic the deformation red blood cells when propagated at constant flow rate in confined capillary tubes, to serve as valuable tool investigate microhaemodynamics.
Despite a large amount of in vitro data, the dynamics airway smooth muscle (ASM) mass increase airways patients with asthma is not well understood. Here, we present novel mathematical model that describes qualitatively growth ASM cells over short and long terms normal inflammatory environments typically observed asthma. The degree accumulation can be explained by an rate at which switch between non-proliferative proliferative states, driven episodic events. Our explores idea remodelling due...
The dynamics of blood flow in the smallest vessels and passages human body, where cellular character becomes prominent, plays a dominant role transport exchange solutes. Recent studies have revealed that microhaemodynamics vascular network is underpinned by its interconnected structure, certain structural alterations such as capillary dilation blockage can substantially change patterns. However, for extravascular media with disordered microstructure (e.g. porous intervillous space placenta),...
The primary exchange units in the human placenta are terminal villi, which fetal capillary networks surrounded by a thin layer of villous tissue, separating from maternal blood. To understand how complex spatial structure villi influences their function, we use an image-based theoretical model to study effect tissue metabolism on transport solutes blood into circulation. For solute that is taken up under first-order kinetics, show transition between flow-limited and diffusion-limited depends...
Получено 30 ноября 2007 г
The flow and transport of solute molecules in the intricate structure placenta make organ a fetal life-support system.
The transport of a scalar quantity in disordered medium is common problem science and engineering. To understand the interplay between deterministic dynamics stochasticity underlying microstructure, we analyse simple model for unidirectional advection–diffusion reaction over random array point sinks. homogenized concentration distribution periodic provides leading-order approximation wide range ergodic stationary sink distributions comparable mean density. However fluctuations about this...
Enlargement of perivascular and ventricular spaces are associated with neuroinflammation in neurodegenerative diseases, including cerebral small vessel disease Alzheimer’s disease. In this study we develop methodology for measuring the anatomy space around anterior artery partial-volume-free estimates total CSF volume apply approach to TgF344-AD rats. Neither area under curve profiles, nor overall width space, or differed between rats wild-types.