A5040805937- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Sulfur Compounds in Biology
- Nanoparticle-Based Drug Delivery
- Redox biology and oxidative stress
- DNA and Nucleic Acid Chemistry
- Glutathione Transferases and Polymorphisms
- Barrier Structure and Function Studies
- Amino Acid Enzymes and Metabolism
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Dendrimers and Hyperbranched Polymers
Instituto de Salud Carlos III
2016-2022
Biomedical Research Networking Center on Neurodegenerative Diseases
2016-2022
Centro de Investigación Biomédica en Red
2022
University of Castilla-La Mancha
2016-2022
the increase in lifespan Western countries predicts that CNS diseases
Glioblastomas are the most common malignant primary brain tumours in adults and one of aggressive difficult-to-treat cancers. No effective treatment exits actually for this tumour new therapeutic approaches needed disease. One possible innovative approach involves nanoparticle-mediated specific delivery drugs and/or genetic material to glioblastoma cells where they can provide benefits. In present work, we have synthesised characterised several second generation amphiphilic polylysine...
To study the structural requirements that a cyclooligosaccharide-based nanoparticle must fulfill to be an efficient siRNA transfection vector.siRNA protection from degradation by RNAses, efficiency and thermodynamic parameters of nanoparticle/siRNA interactions were studied on pairs amphiphilic molecules using biochemical techniques molecular dynamics.The lower solvent accessible surface area in presence nanoparticle, higher RNAse-mediated corresponding nanocomplex; moderate binding energy...
Synthetic double-stranded small interfering RNAs (siRNAs) mimic interference (RNAi) and can bind target mRNAs with a high degree of specificity, leading to selective knockdown the proteins they encode. However, siRNAs are very labile must be both protected transported by nanoparticles efficiently delivered into cells. In this work, we used Janus-type polycationic amphiphilic β-cyclodextrin derivative transfect targeting encoding mitogen-activated protein kinase (p42-MAPK) or Ras homolog...
Metastatic tumors with moderate radiosensitivity account for most cancer-related deaths, highlighting the limitations of current radiotherapy regimens. The xCT-inhibitor sulfasalazine (SAS) sensitizes cancer cells to by blocking cystine uptake via xCT membrane antiporter, and thereby glutathione (GSH) synthesis protecting against radiation-induced oxidative stress. expression in multiple tumor types implies it as a target generic rather than confined few subtypes. However, SAS has limited...
Abstract Metastatic tumors with moderate radiosensitivity account for most cancer-related deaths, highlighting the limitations of current radiotherapy regimens. The xCT-inhibitor sulfasalazine (SAS) sensitizes cancer cells by blocking xCT-mediated cystine uptake, and thereby glutathione (GSH) synthesis protecting against radiation-induced oxidative stress. However, SAS has limited clinical potential as a radiosensitizer due to side effects low bio-availability. Using starting point, we...