About
Contact & Profiles
A5044911890
Research Areas
- Cellular transport and secretion
- Protein Degradation and Inhibitors
- RNA Interference and Gene Delivery
ABL Bio (South Korea)
2022
Effective delivery of therapeutics to the brain is challenging. Molecular shuttles use receptors expressed on endothelial cells deliver therapeutics. Antibodies targeting transferrin receptor (TfR) have been widely developed as molecular shuttles. However, TfR-based approach raises concerns about safety and developmental burden. Here, we report insulin-like growth factor 1 (IGF1R) an ideal target for shuttle. We also describe Grabody B, antibody against IGF1R, a B has broad cross-species...
10.1016/j.crmeth.2022.100338
article
EN
cc-by-nc-nd
Cell Reports Methods
2022-11-01
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