A5083663537- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Cell Adhesion Molecules Research
- Cancer, Lipids, and Metabolism
- Cancer Cells and Metastasis
- Monoclonal and Polyclonal Antibodies Research
- Neuroendocrine Tumor Research Advances
- Glycosylation and Glycoproteins Research
- Liver physiology and pathology
- Protease and Inhibitor Mechanisms
- Neuroblastoma Research and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Venomous Animal Envenomation and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- TGF-β signaling in diseases
- Lipid metabolism and disorders
- Transgenic Plants and Applications
- Bioactive Natural Diterpenoids Research
- HER2/EGFR in Cancer Research
- Protein purification and stability
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Gastric Cancer Management and Outcomes
- CAR-T cell therapy research
ABL Bio (South Korea)
2017-2024
La Jolla Alcohol Research
2015
Hanwha Solutions (South Korea)
2015
Sanford Burnham Prebys Medical Discovery Institute
2010-2015
Discovery Institute
2015
Huashan Hospital
2015
Fudan University
2015
University of California, San Francisco
2005-2012
Exelixis (United States)
2011-2012
Pfizer (United States)
2012
Abstract Invasion and metastasis increase after the inhibition of VEGF signaling in some preclinical tumor models. In present study we asked whether selective is sufficient to invasion c-Met block this effect. Treatment pancreatic neuroendocrine tumors RIP-Tag2 mice with a neutralizing anti-VEGF antibody reduced burden but increased hypoxia, hypoxia-inducible factor-1α, activation also metastasis. However, were by concurrent PF-04217903 or PF-02341066 (crizotinib). A similar benefit was...
Journal Article In situ force mapping of mammary gland transformation Get access Jose I. Lopez, Lopez Department Surgery and Center for Bioengineering Tissue Regeneration, University California at San Francisco Surgery, 513 Parnassus Ave, HSE 565, Francisco, CA 94143-0456. Fax: (415) 476-3985; Tel: 476-3826 Search other works by this author on: Oxford Academic Google Scholar Inkyung Kang, Kang Weon-Kyoo You, You Anatomy, 94143 Donald M. McDonald, McDonald Valerie Weaver 476-3826Departments...
Angiogenesis inhibitors that block VEGF receptor (VEGFR) signaling slow the growth of many types tumors, but eventually disease progresses. Multiple strategies are being explored to improve efficacy by concurrent inhibition other functionally relevant tyrosine kinases (RTK). XL880 (foretinib, GSK1363089) and XL184 (cabozantinib) small-molecule potently multiple RTKs, including VEGFR hepatocyte factor c-Met, which can drive tumor invasion metastasis. This study compared cellular effects with...
The NG2 proteoglycan stimulates the proliferation and migration of various immature cell types, including pericytes. However, role in mediating pericyte/endothelial interaction has been less clear. In this study, we show that pericyte-specific ablation causes several structural deficits blood vessels intracranial B16F10 melanomas, decreased pericyte ensheathment endothelial cells, diminished formation junctions, reduced assembly vascular basal lamina. These result tumor vessel patency,...
The neuron-glial antigen 2 (NG2) proteoglycan promotes pericyte recruitment and mediates interaction with endothelial cells. In the absence of NG2, blood vessel development is negatively impacted in several pathological models. Our goal this study was to determine effect NG2 ablation on early function vessels mammary tumors tumor virus-driven polyoma middle T (MMTV-PyMT) transgenic mouse, correlate these vascular changes alterations growth.Three different paradigms (spontaneous tumors,...
With the emerging novel biotherapeutics that are typically difficult-to-express (DTE), improvement is required for high-yield production. To identify targets can enhance DTE protein production, we performed genome-wide fluorescence-activated cell sorting (FACS)-based clustered regularly interspaced short palindromic repeats (CRISPR) knockout screening in bispecific antibody (bsAb)-producing Chinese hamster ovary (CHO) cells. The screen identified two highest-scoring genes,
Several angiogenesis inhibitors targeting the vascular endothelial growth factor (VEGF) signaling pathway have been approved for cancer treatment. However, VEGF alone were shown to promote tumor invasion and metastasis by increasing intratumoral hypoxia in some preclinical clinical studies. Emerging reports suggest that Delta-like ligand 4 (Dll4) is a promising target of inhibition augment effects inhibitors. To evaluate simultaneous blockade against Dll4, we developed bispecific antibody,...
Delta-like-ligand 4 (DLL4) is a promising target to augment the effects of VEGF inhibitors. A simultaneous blockade VEGF/VEGFR and DLL4/Notch signaling pathways leads more potent anti-cancer by synergistic anti-angiogenic mechanisms in xenograft models. bispecific antibody targeting DLL4 (ABL001/NOV1501/TR009) demonstrates vitro vivo biological activity compared or monoclonal antibodies alone currently being evaluated phase 1 clinical study heavy chemotherapy targeted therapy pre-treated...
Journal Article A Novel Metalloprotease from Gloydius halys Venom Induces Endothelial Cell Apoptosis through Its Protease and Disintegrin-Like Domains Get access Weon-Kyoo You, You Search for other works by this author on: Oxford Academic PubMed Google Scholar Hyun-Ji Seo, Seo Kwang-Hoe Chung, Chung Doo-Sik Kim The of Biochemistry, Volume 134, Issue 5, November 2003, Pages 739–749, https://doi.org/10.1093/jb/mvg202 Published: 01 2003
Early stage growth of intracranial B16F10 tumors is reduced by 87% in myeloid-specific NG2 null (Mac-NG2ko) mice and 77% pericyte-specific (PC-NG2ko) mice, demonstrating the importance proteoglycan each these stromal compartments. In both genotypes, loss pericyte-endothelial cell interaction results numerous structural defects tumor blood vessels, including decreased formation endothelial junctions assembly vascular basal lamina. All deficits are larger Mac-NG2ko than PC-NG2ko correlating...
Effective delivery of therapeutics to the brain is challenging. Molecular shuttles use receptors expressed on endothelial cells deliver therapeutics. Antibodies targeting transferrin receptor (TfR) have been widely developed as molecular shuttles. However, TfR-based approach raises concerns about safety and developmental burden. Here, we report insulin-like growth factor 1 (IGF1R) an ideal target for shuttle. We also describe Grabody B, antibody against IGF1R, a B has broad cross-species...
Human malignant gliomas are highly vascularized and aggressive tumors. Angiogenesis inhibitors have been shown to induce regression of a variety primary metastatic tumors in vivo. However, their usefulness treating brain is not well understood. Angiostatin, multiple kringle (1–4 5)–containing fragment plasminogen, one the effective natural cryptic angiogenesis inhibitors. In our study, therapeutic efficacy non-glycosylated small molecular size recombinant kringles 1–3 (rPK1–3) was examined...
Da-Hyun Kim, Seul Lee, Hyeok Gu Kang, Hyun-Woo Park, Han-Woong Dongin Dong-Hoon Yoem, Jin-Hyung Ahn, Eunsin Ha, Weon-Kyoo You, Sang Hoon Seok-Jun Kim & Kyung-Hee Chun. BMB Reports 2020;53:533-8. https://doi.org/10.5483/BMBRep.2020.53.10.103
Abstract Inhibition of vascular endothelial growth factor receptor (VEGFR) signaling can slow tumor and prolong host survival but also promote invasiveness metastasis in some preclinical models. Although the mechanisms involved are unclear, hypoxia-induced activation pro-invasive pathways involving hepatocyte its c-Met may be a factor. We sought to address this mechanism by determining whether inhibition VEGFR together with reduce improve as well growth. Our approach was compare effects...
Endostatin, a carboxyl-terminal fragment of collagen XVIII is known as an anti-angiogenic agent, that specifically inhibits the proliferation endothelial cell and growth several primary tumor. We report here purification characterization recombinant murine endostatin (rmEndostatin) which was expressed in prokaryotic expression system. This rmEndostatin has similar physiochemical properties yeast-produced endostatin, it also migration bovine capillary cells stimulated by basic fibroblast...