A5050618883- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- HER2/EGFR in Cancer Research
- Cancer-related gene regulation
- Cell Adhesion Molecules Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Extracellular vesicles in disease
- Genomics and Chromatin Dynamics
- Parkinson's Disease Mechanisms and Treatments
- Genetics and Neurodevelopmental Disorders
- Acute Myeloid Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Nuclear Receptors and Signaling
- DNA Repair Mechanisms
- Biochemical and Molecular Research
- Cancer Genomics and Diagnostics
- RNA Interference and Gene Delivery
- Helicobacter pylori-related gastroenterology studies
- Histone Deacetylase Inhibitors Research
- Immune Response and Inflammation
- Immune cells in cancer
University of Cologne
2021-2024
University Hospital Cologne
2022
Northwestern University
2021
Kiel University
2018-2020
Cluster of differentiation 109 (CD109) is a glycosylphosphatidylinositol (GPI)-anchored protein expressed on primitive hematopoietic stem cells, activated platelets, CD4+ and CD8+ T keratinocytes. In recent years, CD109 was also associated with different tumor entities identified as possible future diagnostic marker linked to reduced patient survival. Also, cell signaling pathways were proposed targets for interference including the TGFβ, JAK-STAT3, YAP/TAZ, EGFR/AKT/mTOR pathways. Here, we...
A disintegrin and metalloproteinase (ADAM) 17 has been implicated in many shedding processes. Major substrates of ADAM17 are TNF-α, IL-6R, ligands the epidermal growth factor receptor. The essential role protease is emphasized by fact that deficiency lethal mice. To study function vivo, we generated viable hypomorphic mice called ADAM17ex/ex Recent studies indicated regulation proteolytic activity cellular processes such as cytoplasmic phosphorylation removal prodomain furin cleavage....
Myeloperoxidase (MPO) is an enzyme that functions in host defense. MPO released into the vascular lumen by neutrophils during inflammation and may adhere subsequently penetrate endothelial cells (ECs) coating walls. We show enters nucleus of ECs binds chromatin independently its enzymatic activity. drives decondensation at binding sites enhances condensation neighboring regions. It loci relevant for endothelial-to-mesenchymal transition (EndMT) affects migratory potential ECs. Finally,...
Polycomb Repressive Complex 2 (PRC2) is an epigenetic regulator that trimethylates lysine 27 of histone 3 (H3K27me3) and essential for embryonic development cellular differentiation. H3K27me3 associated with transcriptionally repressed chromatin established when PRC2 allosterically activated upon methyl-lysine binding by the regulatory subunit EED. Automethylation catalytic EZH2 stimulates its activity unknown mechanism. Here, we show forms a dimer on in which inactive, automethylated...
Although extensively investigated, cancer is still one of the most devastating and lethal diseases in modern world. Among different types, colorectal (CRC) prevalent mortal, making it an important subject research. The metalloprotease ADAM17 has been implicated development CRC due to its involvement signaling pathways related inflammation cell proliferation. capable releasing membrane-bound proteins from surface a process called shedding. A deficiency activity previously shown have...
ABSTRACT Apoptosis inducing factor 1 (AIFM1) is a flavoprotein essential for mitochondrial function and biogenesis. Its interaction with MIA40, the central component of disulfide relay, accounts some, but not all effects AIFM1 loss. Our high-confidence interactome revealed novel partners AIFM1. For one these interactors, adenylate kinase 2 (AK2), an enzyme maintaining cellular adenine nucleotide pools, binding specifically stabilized isoform AK2A via its C-terminus. High resolution cryo-EM...
ABSTRACT Myeloperoxidase (MPO) is an enzyme that functions in host defence by catalysing the formation of reactive oxygen intermediates. Synthesized majorly myeloid progenitor cell types and neutrophils, MPO released into vascular lumen during inflammation, where it may adhere subsequently enter endothelial cells coating walls. Here, we show actually enters nucleus these binds chromatin independently its enzymatic activity to cause changes structure. At binding sites, drives decondensation,...