A5101412757- Chronic Obstructive Pulmonary Disease (COPD) Research
- RNA modifications and cancer
- Iron Metabolism and Disorders
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Neonatal Respiratory Health Research
- Hemoglobinopathies and Related Disorders
- Erythropoietin and Anemia Treatment
- Mitochondrial Function and Pathology
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
Weill Cornell Medicine
2020-2023
Cornell University
2016-2023
New York Hospital Queens
2016
Presbyterian Hospital
2016
NewYork–Presbyterian Hospital
2016
Chronic obstructive pulmonary disease (COPD) is a debilitating lung associated with cigarette smoking. Alterations in local and systemic iron regulation are progression pathogenesis. Hepcidin, an regulatory peptide hormone, altered subjects COPD; however, the molecular role of hepcidin COPD pathogenesis remains to be determined. In this study, using murine model smoke-induced COPD, we demonstrate that circulating levels inhibited by smoke. We show smoke exposure increases erythropoietin bone...
Cigarette smoke (CS) exposure is a risk factor for many chronic diseases including obstructive pulmonary disease (COPD), however the mechanism by which can alter homeostasis and bring about inflammation poorly understood. Here, we showcase novel role in regulating long noncoding RNAs (lncRNAs), showing that it activates lincRNA-Cox2, previously characterized as functional inflammatory regulation. Exposing lincRNA-Cox2 murine models to vivo confirmed regulator of gene expression response both...
Chronic obstructive pulmonary disease (COPD) is an inflammatory characterised by emphysema and chronic bronchitis. Cigarette smoke (CS) inhalation constitutes the primary risk factor for COPD progression dysregulates numerous pathways essential to lung-resident alveolar macrophage (AM) circulating bone marrow-derived (BMDM) function. Aberrant iron metabolism one such hallmark: AMs are lung resident iron-positive cells, with iron-related proteins elevated in patient bronchoalveolar lavage...
Abstract Cigarette smoke (CS) exposure is a risk factor for many chronic diseases including obstructive pulmonary disease (COPD), however the mechanism by which can alter homeostasis and bring about inflammation poorly understood. Here, we showcase novel role in regulating long noncoding RNAs (lncRNAs), showing that it activates lincRNA-Cox2 , previously characterized as functional inflammatory regulation. Exposing murine models to vivo confirmed regulator of gene expression response both...