A5078321903- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Neurotransmitter Receptor Influence on Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Pharmacological Receptor Mechanisms and Effects
- Cannabis and Cannabinoid Research
- Neurogenesis and neuroplasticity mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Mast cells and histamine
- Cancer-related molecular mechanisms research
- Alzheimer's disease research and treatments
- Olfactory and Sensory Function Studies
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Medicinal Plants and Neuroprotection
- COVID-19 Clinical Research Studies
- Sleep and Wakefulness Research
University of Kurdistan
2014-2024
University of Tehran
2004-2007
Tehran University of Medical Sciences
2004
The development of nanomaterials with multienzyme activity for advanced sensing and biosensing assays has attracted attention. In this study, a Cu-Co bimetallic nitrogen-doped carbon catalyst (CoCu@NC) was synthesized. prepared exhibit catalase- oxidase-like mimicking activities by adjusting the pH. catalase-like CoCu@NC investigated quenching terephthalic acid (TA) fluorescence at pH 11 in presence H2O2, while its oxidase behavior confirmed oxidation 3,3',5,5'-tetramethylbenzidine (TMB) as...
Involvement of the dopamine receptors in basolateral amygdala (BLA) effects histamine on anxiety-like behaviors elevated plus maze male Wistar rats was investigated. The results showed that bilateral intra-BLA injections (2.5, 5 and 7.5 µg/rat) induced an anxiogenic-like effect, revealed by decreases percentage open arm time (%OAT) entries (%OAE). Intra-BLA administration D1 receptor agonist, SKF38393 (0.25 µg/rat), D2 quinpirole (0.03 0.05 decreased %OAT but not %OAE. Conversely,...
Introduction The potential benefits of natural ingredients in the alleviation neurodegenerative disorders are great interest. Alpha-pinene (APN) is an essential oil belonging to monoterpenes with multiple beneficial effects. In this study, possible improving effects alpha-pinene on memory impairment induced by kainic acid and underlying molecular mechanisms were examined. Methods Memory was i.c.v. injection (KA) male Wistar rats. (50 mg/kg/day, i.p.) injected for 21 days, including 14 days...
Abstract The possible involvement of N ‐methyl‐ D ‐aspartate (NMDA) receptors in the nucleus accumbens (NAc) nicotine's effect on impairment memory by morphine was investigated. A passive avoidance task used for assessment male Wistar rats. Subcutaneous (s.c.) administration (5 and 10 mg/kg) after training impaired performance animals when tested 24 h later. Pretest same doses reversed because post‐training opioid. Moreover, nicotine (0.2 0.4 mg/kg, s.c.) before test prevented given...
The effect of intracerebroventricular (i.c.v.) injections L-arginine, a nitric oxide (NO) precursor and L-NAME, an inhibitor NO synthase, on retrieval state-dependent memory induced by LiCl (lithium) was investigated. A one-trial step-down inhibitory avoidance task used for assessment in adult male NMRI mice. Intraperitoneal administration lithium (10 mg/kg), immediately after training, impaired the test day. Pretest different doses (5, 10 20 mg/kg) reversed impairment caused posttraining...
This study was designed to evaluate the effect of repeated morphine treatment on rat behavioral responses. In genetic section, mRNA expression NMDA receptor subunits (NR1 and NR2A) measured in certain areas male brain (striatum, prefrontal cortex, hippocampus, hypothalamus amygdala). animal models such as locomotion, oral stereotypy, state-dependent memory a passive avoidance test evaluated presence or absence MK801 (NMDA antagonist). Our results showed that chronic treatment, followed by...
In the present study influence of dopaminergic system(s) amygdala on anxiolytic-like effect cannabinoid CB1 receptor agonist, arachydonilcyclopropylamide (ACPA), in male Wistar rats was investigated. An elevated plus-maze test anxiety used to assess anxiety-like behaviors. The results showed that bilateral intra-amygdala injections ACPA (0.125, 1.25 and 5 ng/rat) mixed dopamine D1/D2 apomorphine, at different doses (0.001, 0.01 0.1 µg/rat) increased percentage open arm time (%OAT) entries...
Chitosan‐based molecular imprinted polymer (CS‐MIP) nanogel is prepared in the presence of morphine template, fully characterized and used as a new vehicle to extend duration analgesic effect Naval Medical Research Institute mice. The CS‐MIP with ≈25 nm size range exhibits 98% loading efficiency, vitro release studies show an initial burst followed by extended slow morphine. In order study feasibility carrier, 20 mice are divided into two groups randomly received subcutaneous injection...
SUMMARY Repeated administration of psychostimulants and µ‐opioid receptor agonists elicits a progressive enhancement drug‐induced behavioural responses, phenomenon termed sensitization. These changes in behaviour may reflect plastic requiring regulation α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole proprionic acid (AMPA) function. In the present study, rats were treated for 7 days with saline or morphine (10 mg/kg). After washout period either 24 h days, locomotion, oral stereotypy state‐dependent...
Involvement of the dopamine D1 and D2 receptors in nucleus accumbens (NAc) with interaction between morphine nicotine on inhibitory avoidance (IA) memory was investigated. A step-through type tasks used to assess male Wistar rats. The results showed that subcutaneous (s.c.) administration (7.5 mg/kg) after training decreased retrieval IA animals when tested 24 h later. Pre-test same dose significantly reversed deficiency retrieval. also pre-test (0.2 0.4 mg/kg, s.c.) by itself mimicked...
In the present study interactions between analgesic effect of morphine with blockade ATP-sensitive potassium channels and L-type calcium were investigated in alloxan-induced diabetic mice. A hot plate test was used to assess drugs adult male NMRI All injected through an intraperitoneal route. mouse model established by injections alloxan for three consecutive days. Seventy-two hours after final injection, mice a blood glucose level higher than 11.1 mmol/l considered as diabetic. The results...