A5016729988- Influenza Virus Research Studies
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Vaccine Coverage and Hesitancy
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Herpesvirus Infections and Treatments
- Respiratory viral infections research
- Antimicrobial Resistance in Staphylococcus
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- COVID-19 epidemiological studies
- Viral gastroenteritis research and epidemiology
- Smoking Behavior and Cessation
- Pneumonia and Respiratory Infections
- Palliative Care and End-of-Life Issues
- Endoplasmic Reticulum Stress and Disease
- Clostridium difficile and Clostridium perfringens research
- Infective Endocarditis Diagnosis and Management
- Immune Cell Function and Interaction
- Bacterial Identification and Susceptibility Testing
- Viral Infections and Immunology Research
- Patient Dignity and Privacy
- Antifungal resistance and susceptibility
- Cancer-related gene regulation
Weizmann Institute of Science
2016-2020
Semmelweis University
2015-2016
University of Pittsburgh
2009-2012
Decision Sciences (United States)
2009
Host shutoff is a common strategy used by viruses to repress cellular mRNA translation and concomitantly allow the efficient of viral mRNAs. Here we use RNA-sequencing ribosome profiling explore mechanisms that are being utilized Influenza A virus (IAV) induce host shutoff. We show transcripts not preferentially translated instead decline in protein synthesis mediated takeover on pool. Our measurements also uncover strong variability levels reduction, revealing short less affected IAV....
During the 2009 H1N1 influenza epidemic, policy makers debated over whether, when, and how long to close schools. While closing schools could have reduced transmission thereby preventing cases, deaths, health care costs, it may also incurred substantial costs from increased childcare needs lost productivity by teachers other school employees. A combination of agent-based Monte Carlo economic simulation modeling was used determine cost-benefit (vs. not schools) for different durations (range:...
Viruses are known for their extremely compact genomes composed almost entirely of protein-coding genes. Nonetheless, four long noncoding RNAs (lncRNAs) encoded by human cytomegalovirus (HCMV). Although these accumulate to high levels during lytic infection, functions remain largely unknown. Here, we show that HCMV-encoded lncRNA4.9 localizes the viral nuclear replication compartment, and its depletion restricts DNA growth. RNA4.9 is transcribed from HCMV origin (oriLyt) forms an RNA-DNA...
Human herpesvirus-6 (HHV-6) A and B are ubiquitous betaherpesviruses, infecting the majority of human population. They encompass large genomes our understanding their protein coding potential is far from complete. Here, we employ ribosome-profiling systematic transcript-analysis to experimentally define HHV-6 translation products. We identify hundreds new open reading frames (ORFs), including upstream ORFs (uORFs) internal (iORFs), generating a complete unbiased atlas proteome. By...
Abstract The B7 family member, B7H6, is a ligand for the natural killer cell receptor NKp30. B7H6 hardly expressed on normal tissues, but undergoes upregulation different types of tumors, implicating it as an attractive target cancer immunotherapy. molecular mechanisms that control expression are poorly understood. We report in contrast to other NK ligands, endoplasmic reticulum (ER) stress upregulates mRNA levels and surface expression. induction by ER requires protein kinase R-like (PERK),...
Methicillin-resistant Staphylococcus aureus (MRSA) can cause severe infections in patients undergoing haemodialysis. Routine periodic testing of haemodialysis and attempting to decolonize those who test positive may be a strategy prevent MRSA infections. The economic value such has not yet been estimated. We constructed Markov computer simulation model evaluate the employing routine (agar-based or PCR) at different prevalence, spontaneous clearance, costs decolonization success rates,...
Please cite this paper as: Lee et al. (2011) The potential economic value of a ‘universal’ (multi‐year) influenza vaccine. Influenza and Other Respiratory Viruses 6(3), 167–175. Background Limitations the current annual vaccine have led to ongoing efforts develop vaccine, i.e., one that targets ubiquitous portion virus so coverage single vaccination can persist for multiple years. Objectives To estimate compared standard starting in pediatric population (2–18 year olds), over course their...
Abstract Human herpesvirus 6 (HHV-6) A and B are highly ubiquitous betaherpesviruses, infecting the majority of human population. Like other herpesviruses, they encompass large genomes our understanding their protein coding potential is far from complete. Here we employ ribosome profiling systematic transcript analysis to experimentally define HHV-6 translation products follow temporal expression. We identify hundreds new open reading frames (ORFs), including many upstream ORFs (uORFs)...