A5101607708- Anesthesia and Neurotoxicity Research
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Barrier Structure and Function Studies
- Neurobiology and Insect Physiology Research
- Surgical Sutures and Adhesives
- Cleft Lip and Palate Research
- bioluminescence and chemiluminescence research
- Regulation of Appetite and Obesity
- Melanoma and MAPK Pathways
- Biopolymer Synthesis and Applications
- Bacteriophages and microbial interactions
- Infant Health and Development
- Hematopoietic Stem Cell Transplantation
- IL-33, ST2, and ILC Pathways
- Lattice Boltzmann Simulation Studies
- Biological Research and Disease Studies
- Extracellular vesicles in disease
- Microtubule and mitosis dynamics
- Neuropeptides and Animal Physiology
- Immune Response and Inflammation
- Space Science and Extraterrestrial Life
- Circular RNAs in diseases
Southwest Jiaotong University
2021-2023
Chengdu Third People's Hospital
2023
Fudan University
2021
Nanjing University
2019
Nanjing General Hospital of Nanjing Military Command
2019
Third Hospital of Nanchang
2017
China Medical University
2015
Chinese Academy of Sciences
2014
Institute of Zoology
2014
International Drug Development
2013
Juvenile hormone (JH), a sesquiterpenoid produced by the corpora allata, coordinates insect growth, metamorphosis, and reproduction. While JH action for repression of larval metamorphosis has been well studied, molecular basis in promoting adult reproduction not fully elucidated. Methoprene-tolerant (Met), receptor, recently shown to mediate during as vitellogenesis, but again, precise mechanism underlying latter lacking. We have now demonstrated using Met RNAi phenocopy JH-deprived...
Magnetic hyperthermia (MHT)-mediated thermal ablation therapy has promising clinical applications in destroying primary tumours. However, traditional MHT still presents the challenges of damage to normal tissues adjacent treatment site and destruction tumour-associated antigens due its high onset temperature (> 50 °C). In addition, local tumours often exhibits limited therapeutic inhibition tumour metastasis.To address above defects, a hybrid nanosystem (SPIOs + RPPs) was constructed which...
Diabetes mellitus is associated with an increased risk of breast cancer, but the molecular mechanism underlying this association remains unclear. The aim present study was to investigate effect high glucose and insulin conditions on MCF‑7 cancer cells elucidate mechanisms these effects. High resulted in viability, proliferation, invasion compared normal low conditions. Reverse transcription‑quantitative polymerase chain reaction western blot analyses revealed that receptor substrate 1 (IRS1)...
The intestinal mucosal immune environment requires multiple cells to maintain homeostasis. Although B are among the most important cells, little is known about mechanism that they employ regulate In this study, we found CD11b + significantly accumulated in gut lamina propria and Peyer’s patches dextran sulfate sodium-induced colitis mouse models patients with ulcerative colitis. Adoptive transfer of but not −/− effectively ameliorated exhibited therapeutic effects. Furthermore, were produce...
Functional dyspepsia (FD) is a common functional gastrointestinal (GI) disorder, but its pathophysiology poorly understood. Mast cells (MCs) may play critical role in the development of FD. Therefore, aim this study was to investigate effect MCs on barrier function, tight junction (TJ) proteins and related signaling pathways.The expression TJ claudin-8, ZO-1 occludin biopsy tissues from seven FD patients five controls assessed. Based vivo results, we further investigated (1) MC degranulation...
Abstract The role of spliceosome‐associated protein 130 (SAP130) in gut inflammation, particularly Crohn's disease (CD), remains unclear. aim our study was to analyze correlations between serum SAP130 levels and CD severity, assess its predictive value for the clinical efficacy exclusive enteral nutrition (EEN) CD. Correlations severity were evaluated. receptor Mincle (macrophage‐inducible C‐type lectin) colon tissue active measured. Furthermore, level investigated as a predictor patients...
The objective of this study is to determine the effects Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor Y-27632 on growth, invasion, and migration Tca8113 CAL-27 cells in tongue squamous cell carcinoma (TSCC). methods are as follows: After being routinely cultured for 24 h, were treated with solution. morphological change Y-27632-treated was observed under an optical microscope inverted microscope; MTT assay performed measure density (OD) calculate growth inhibition...
Objective To construct the recombinant lentiviral vector containing human PPFP gene,to observe its expression in 293T cells. Methods The gene was isolated and amplified by PCR technique from PEGFP-C-PPFP plasmid which constructed before. Then subcloned into of vector,pGC-FU (containing Flag gene), to generate vector, pGC-FU-PPFP. correct PPFPgene confirmed PCR, endoenzyme digestion, se-quencing, analysis contrast. Recombinant lentiviruses were produced cells following co-transfection...