OBJECTIVE Sodium–glucose cotransporter 2 (SGLT-2) inhibitors have been shown to reduce liver fat in rodent models. Data regarding the effect of SGLT-2 on human are scarce. This study examined empagliflozin (an inhibitor) patients with type diabetes and nonalcoholic fatty disease (NAFLD) by using MRI-derived proton density fraction (MRI-PDFF). RESEARCH DESIGN AND METHODS Fifty NAFLD were randomly assigned either group (standard treatment for plus 10 mg daily) or control without empagliflozin)...

Abstract Vitamin D deficiency (VDD) owing to its immunomodulatory effects is believed influence outcomes in COVID-19. We conducted a prospective, observational study of patients, hospitalized with Serum 25-OHD level < 20 ng/mL was considered VDD. Patients were classified as having mild and severe disease on basis the WHO ordinal scale for clinical improvement (OSCI). Of 410 patients recruited, VDD (197,48.2%) significantly younger had lesser comorbidities. The levels PTH higher group...

We report a case of an Indian boy who presented with rickets and was thought to have nutritional vitamin D deficiency precipitated by the use anticonvulsant medications. The presence proteinuria lack normalization alkaline phosphatase prompted further evaluation which suggestive type 2 Dent disease secondary mutations in OCRL1 gene. highlights importance urine routine, simple yet useful test rickets.

Background: Remission rates with antithyroid drugs (ATDs) in pediatric Graves' disease (GD) are low. Very few studies report long-term follow-up of GD especially into adulthood.

This study aimed to evaluate the efficacy and safety of a single monthly dose cholecalciferol in healthy school children.A total 118 children class VI residential were selected receive vitamin D supplementation form oral 60,000 IU monthly. Serum calcium 25-hydroxyvitamin (25OHD) levels estimated at 0 12 months. The proportion subjects achieving sufficiency was assessed.The mean 25OHD increased significantly from 12.04±5.27 ng/mL baseline 32.6±7.05 after months (p<0.001). None developed...

To study the clinical profile and risk factors of cerebral edema acute kidney injury in children with diabetic ketoacidosis.Retrospective review medical records.Fifty consecutive patients (age <18 years) admitted to our pediatric intensive care unit a diagnosis ketoacidosis over 5 years.Retrospective analysis records was done, data including patients' age, sex, presenting features, biochemical blood glucose, osmolality, urea, creatinine, venous gas, electrolytes were recorded at admission,...

Aim To study the prevalence of thyroid dysfunction and its association with disease severity in hospitalized patients coronavirus disease-19 (COVID-19). Methods In this retrospective cohort study, function tests (TFT) 236 COVID-19 along demographic, comorbid, clinical, biochemical records were analysed. Patients divided into previous euthyroid or hypothyroid status to observe effect prior hypothyroidism on COVID-19. Results TFT abnormalities common. Low free T3 (FT3), high...

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare recessive disorder resulting from mutations in the autoimmune regulator (AIRE) gene. There no information on AIRE Indians. In cross-sectional study, nine patients (eight families), four referral hospitals India, were studied for by direct sequencing. We screened new 150 controls allele-specific PCR. The had 1-7 known components of APECED. Three unusual manifestations: presentation with type 1 diabetes; chronic...

Mucopolysaccharidosis type VI (MPS VI) is a rare, autosomal recessive lysosomal storage disorder caused by deficient enzymatic activity of N-acetyl galactosamine-4-sulphatase resulting from mutations in the arylsulphatase B (ARSB) gene. The ARSB gene located on chromosome 5q11-q13 and composed eight exons. More than hundred have been reported so far, but mutation spectrum MPS India still unknown. Hence, aim present study was to identify mutational patients with genotype-phenotype association...

Objectives: Children with type 1 diabetes (T1D) need a supportive, non-stigmatizing school environment for self-care activities such as checking blood glucose (BG) and taking pre-meal insulin. Data about T1D in schools developing countries are scarce. We looked at school, attitudes of staff toward care. Material Methods: interviewed, over an 8-week period, consecutive patient-parent dyads attending clinics North (Delhi, Gurgaon, Kanpur), West (Aurangabad), South (Hyderabad) India. Results:...

Pioglitazone improves glycemic control by acting as an insulin sensitizer and is used in the management of Type 2 diabetes mellitus. has recently been at center a controversy with regards to its safety. There no clear consensus on how, when what dose drug should be diabetes. We have summarized our strategy pioglitazone use large private tertiary care - Medanta, Medicity- which may help generating further thought about positioning this anti-diabetic molecule. fourth pecking order oral agents....

Abstract Craniopharyngioma is associated with a wide and interesting variety of sodium states both by itself following surgical resection. These are often challenging to diagnose, especially given their dynamic nature during the perioperative course. We present case boy craniopharyngioma who had hyponatremia due cerebral salt wasting preoperatively, developed diabetes insipidus (DI) intraoperatively proceeded develop hypernatremia adipsic DI. Cerebral rare presenting feature...

Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is rare in children, and localizing the source of EAS often challenging. Here, we report an adolescent boy who presented with Cushingoid features had endogenous ACTH-dependent hypercortisolism on hormonal evaluation. Abdominal ultrasound CT revealed a hepatic lesion characteristics suggestive hemangioma, whereas was tracer non-avid 68Ga-DOTANOC positron emission tomography/CT. A regional sampling ACTH done to confirm as EAS,...

Abstract A 10‐year‐old boy with acute onset cranial diabetes insipidus and multiple autoimmune disorders had evolving panhypopituitarism, thought to be due hypophysitis. Over 18 months, a dramatic clinical course progressive hypopituitarism development of type 1 mellitus was evident. Serial brain imaging showed changes suggestive germinoma.

We analyzed mRNA expression of X-linked inhibitor apoptosis protein (XIAP) in patients with Turner syndrome (TS) and examined its association phenotypic features.XIAP levels were investigated 98 TS total RNA extracted from blood leucocytes by real time quantitative polymerase chain reaction.Levels XIAP significantly lower bicuspid aortic valves (BAV; n=13) than those without (log -1.17±0.3 vs. -0.94±0.2, p=0.002). Significantly higher was seen a mosaic karyotype renal malformations -0.79±0.3...

Persistent Mullerian Duct Syndrome (PMDS) is diagnosed as a discrepancy between masculine external genitalia and female internal during surgery for cryptorchidism or inguinal hernia. Approximately 200 cases have been reported in the literature so far, most of whom are adults. We discuss management an infant presenting with irreducible hernia contralateral undescended testis.

Growth failure can result from various underlying causes, necessitating a thorough evaluation. Reninoma, rare renin-secreting tumor, is an uncommon cause of hypertension, especially in paediatric patients, and has not been associated with growth until now.