Leonard Clinton D’Souza

ORCID: 0000-0003-0311-8189
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About
Contact & Profiles
Research Areas
  • Environmental Toxicology and Ecotoxicology
  • Invertebrate Immune Response Mechanisms
  • Carcinogens and Genotoxicity Assessment
  • Thyroid Cancer Diagnosis and Treatment
  • Ocular Surface and Contact Lens
  • Oral Health Pathology and Treatment
  • Spaceflight effects on biology
  • Public Procurement and Policy
  • Skin Diseases and Diabetes
  • Antioxidant Activity and Oxidative Stress
  • Working Capital and Financial Performance
  • Ovarian function and disorders
  • Pesticide Exposure and Toxicity
  • Reproductive Biology and Fertility
  • Cannabis and Cannabinoid Research
  • S100 Proteins and Annexins
  • Heat shock proteins research
  • Autoimmune and Inflammatory Disorders
  • Connexins and lens biology
  • Sleep and Wakefulness Research
  • Corneal Surgery and Treatments
  • Phytochemicals and Antioxidant Activities
  • Bee Products Chemical Analysis
  • Mitochondrial Function and Pathology
  • Insect Pest Control Strategies

Nitte University
2019-2025

University of Washington
2025

SDM College of Medical Science and Hospital
2016-2019

Benzene, a ubiquitous environmental chemical, is known to cause immune dysfunction and developmental defects. This study aims investigate the relation between benzene-induced toxicity in genetically tractable animal model, Drosophila melanogaster. Further, explored protective role of Heat Shock Protein 70 (Hsp70) against immunotoxicity subsequent impact. larvae exposed benzene (1.0, 10.0, 100.0 mM) were examined for total hemocyte (immune cells) count, phagocytic activity, oxidative stress,...

10.1002/tox.23520 article EN Environmental Toxicology 2022-03-18

Curculigo orchioides is used in Indian and Chinese traditional medicinal systems for various health benefits. However, its toxicological effects are mostly unknown. This study assesses the potential toxicity of aqueous leaf (A.L.) extract C. using Drosophila melanogaster as an experimental model. Preliminary phytochemical tests were followed by Fourier transform infrared (FTIR) to identify functional group A.L. orchioides. larvae/adults exposed varying concentrations through diet,...

10.3390/ijerph192215218 article EN International Journal of Environmental Research and Public Health 2022-11-18

Background AnnexinA2 (AnxA2) membrane deposition has a critical role in HB-EGF shedding as well IL-6 secretion breast cancer cells. This autocrine cycle major cell proliferation, migration and metastasis. The objective of the study is to demonstrate annexinA2-mediated regulation via Her-2 negative progression. Methods Secretory annexinA2, were analysed peripheral blood sample ( n = 20) positive patients 16). Simultaneously, tissue expression was by immunohistochemistry. these secretory...

10.1177/0004563216665867 article EN Annals of Clinical Biochemistry International Journal of Laboratory Medicine 2016-08-05

Limbal stem cell deficiency (LSCD) is one of the leading causes corneal damage. Injury or inflammation in cornea LSCD, which may be unilateral bilateral depending upon cause. epithelial implants successfully improve vision patients with chemical injury‑induced LSCD. Transplantation cultured cells has become a treatment choice for numerous Bilateral LSCD frequently observed general population, where no residual are available ex vivo culture. Allografts associated high risk rejection,...

10.3892/mmr.2019.10691 article EN Molecular Medicine Reports 2019-09-19

There is a long history of informal use Cannabis sativa (commonly called cannabis) for many purposes, including treating various ailments worldwide. However, the legalization cannabis in multiple countries, specifically medical has grabbed researchers' attention to discover scientific evidence regarding cannabis's beneficial effects. Among over 500 identified compounds (cannabinoids), Δ9-Tetrahydrocannabinol (THC) and cannabidiol (CBD) are two major active cannabinoids derived from cannabis....

10.2174/0929867329666220525124818 article EN Current Medicinal Chemistry 2022-05-27

From 2006 to 2014, Supply Chain Management System (SCMS), the global procurement and distribution project for U.S. President9s Emergency Plan AIDS Relief (PEPFAR), distributed over US$1.6 billion worth of antiretroviral drugs other health commodities, with US$263 million purchased from local vendors in 14 countries sub-Saharan Africa. A simple framework was developed 39 suppliers 4 were interviewed between 2013 2014 understand how SCMS sourcing impacted supplier development. reported new...

10.9745/ghsp-d-18-00083 article EN cc-by Global Health Science and Practice 2018-10-03
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