A5025772144- Environmental Toxicology and Ecotoxicology
- Carcinogens and Genotoxicity Assessment
- Advanced Radiotherapy Techniques
- Pesticide Exposure and Toxicity
- Metabolism, Diabetes, and Cancer
- Invertebrate Immune Response Mechanisms
- Advances in Oncology and Radiotherapy
- Economic and Financial Impacts of Cancer
- Air Quality and Health Impacts
- Head and Neck Cancer Studies
- Childhood Cancer Survivors' Quality of Life
- DNA Repair Mechanisms
- Radiation Dose and Imaging
- Lymphoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Cancer Diagnosis and Treatment
- Nanoparticles: synthesis and applications
- Cancer, Hypoxia, and Metabolism
- Insect and Pesticide Research
- Heat shock proteins research
- Breast Cancer Treatment Studies
- Food Science and Nutritional Studies
- Animal testing and alternatives
Nitte University
2016-2025
Rajiv Gandhi Cancer Institute and Research Centre
2020-2025
Defence Research and Development Organisation
2025
Newcastle University Singapore
2024
University of Delhi
2022-2024
Northwell Health
2011-2022
Central Forensic Science Laboratory
2022
National Institute of Technology Hamirpur
2021
Indira Gandhi Institute of Medical Sciences
2021
Indian Institute of Toxicology Research
2008-2019
Hematopoietic stem/progenitor cells in the adult mammalian bone marrow ensure blood cell renewal. Their cellular microenvironment, called 'niche', regulates hematopoiesis both under homeostatic and immune stress conditions. In Drosophila hematopoietic organ, lymph gland, posterior signaling center (PSC) acts as a niche to regulate response such wasp parasitism. This relies on differentiation of lamellocytes, cryptic type, dedicated pathogen encapsulation killing. Here, we establish that...
Abstract Self-renewal and differentiation of mammalian haematopoietic stem cells (HSCs) are controlled by a specialized microenvironment called ‘the niche’. In the bone marrow, HSCs receive signals from both endosteal vascular niches. The posterior signalling centre (PSC) larval Drosophila organ, lymph gland, regulates blood cell under normal conditions also plays key role in controlling haematopoiesis immune challenge. Here we report that system contributes to gland homoeostasis. Vascular...
Benzene, a ubiquitous environmental chemical, is known to cause immune dysfunction and developmental defects. This study aims investigate the relation between benzene-induced toxicity in genetically tractable animal model, Drosophila melanogaster. Further, explored protective role of Heat Shock Protein 70 (Hsp70) against immunotoxicity subsequent impact. larvae exposed benzene (1.0, 10.0, 100.0 mM) were examined for total hemocyte (immune cells) count, phagocytic activity, oxidative stress,...
Purpose: To present a retrospective analysis of the efficacy, toxicity, and quality life (QoL) patients treated with OAR Extreme -sparing stereotactic body radiotherapy (SBRT) in previously-irradiated head neck cancer. Materials/Methods: From 11/2012 to 7/2015, 60 in-field recurrence cancer underwent re-irradiation SBRT. Retreatment sites included aerodigestive tract (43%), lateral (22%), skull base (35%). The median prior RT dose was 63.6 Gy time from irradiation 16.5 months. volume 61.0...
Pulmonary toxicity is one of the most common morbidities experienced by childhood cancer survivors (CCS). The aim this study was to identify prevalence, pattern dysfunction, and risk factors among CCS compare with age sex matched controls. Details demographic pulmonary-toxic treatment at least 2 years off-treatment were collected a cross-sectional analysis pulmonary function test (PFT) performed. Spirometry findings categorized as normal, restrictive, or obstructive diffusing capacity carbon...