A5071981985- Extracellular vesicles in disease
- Cancer-related gene regulation
- Pancreatitis Pathology and Treatment
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Sarcoma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Financial Literacy, Pension, Retirement Analysis
- Hippo pathway signaling and YAP/TAZ
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Cancer Research and Treatments
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Neurogenesis and neuroplasticity mechanisms
- Molecular Communication and Nanonetworks
- Lattice Boltzmann Simulation Studies
- Medical Imaging and Pathology Studies
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2018-2024
University of Aveiro
2018-2023
Universidade do Porto
2019-2022
IPO Porto
2021
Wake Forest University
2014
Protein methyltransferases have been shown to methylate histone and non-histone proteins, leading regulation of several biological processes that control cell homeostasis. Over the past few years, histone-lysine N-methyltransferase SETD7 (SETD7; also known as SET7/9, KIAA1717, KMT7, SET7, SET9) has emerged an important regulator at least 30 proteins a potential target for treatment human diseases. This review discusses current knowledge structure subcellular localization SETD7, well its...
Intratumor heterogeneity drives cancer progression and therapy resistance. However, it has yet to be determined whether how subpopulations of cells interact this interaction affects the tumour.
Abstract Pancreatic ductal adenocarcinoma (PDAC), a lethal disease, requires grasp of its biology for effective therapies. Exosomes, implicated in cancer, are poorly understood living systems. Here we use the genetically engineered mouse model (ExoBow) to map spatiotemporal distribution exosomes from healthy and PDAC pancreas vivo determine their biological significance. We show that, within microenvironment, cancer cells establish preferential communication routes through with associated...
Individuals within specific risk groups for pancreatic ductal adenocarcinoma (PDAC) [mucinous cystic lesions (MCLs), hereditary (HR), and new-late onset diabetes mellitus (NLOD)] represent an opportunity early cancer detection. Endoscopic ultrasound (EUS) is a premium image modality PDAC screening precursor lesion characterization. While no biomarker currently clinically available this purpose, glypican-1 (GPC1) overexpressed in the circulating exosomes (crExos) of patients with compared...
SETD7 (SET7/9, KMT7) is a lysine methyltransferase that targets master regulators of cell proliferation and differentiation. Here, the impact inhibiting catalytic activity on mammary epithelial differentiation was studied by focusing genes associated with differentiation, lactogenesis, lipid metabolism in HC11 EpH4 lines. Setd7 mRNA protein levels were induced upon lactogenic both Inhibition compound (R)-PFI-2 increased downregulated E-cadherin, beta-catenin, lactoferrin, insulin-like growth...
Glioblastoma (GBM) is an aggressive primary brain tumor with a dismal prognosis. However, due to their tumor-tropic migratory capacity, stem cells are emerging as feasible delivery vehicles therapeutically target and invasive cells. this approach faces number of hurdles, including: (1) the potential tumorigenic cancer propagating capacity pluripotent cells; (2) inability obtain certain autologous Therefore goal work establish therapeutic newly discovered neural-like cell (NLSC) that we...
Introduction: Glypican-1(GPC1), a cell surface proteoglycan, is overexpressed in pancreatic cancer and specifically enriched on cancer-cell-derived circulating exosomes(crExos). Levels of GPC1+ crExos correlate with tumour burden survival patients adenocarcinoma(PDAC). Aim: Characterize levels PDAC associated risk groups. Methods: Unicentric prospective cohort study, PDAC(cytology/histology confirmation), cystic mucinous neoplasm(CMN), chronic pancreatitis(CP) hereditary for PDAC(HR), namely...
Abstract Intra-tumor heterogeneity represents a major challenge for cancer treatment. Resistance to therapy and tumorigenic ability varies greatly between distinct subpopulations of cells. Intercellular communication is critical establish cooperative environment that maintains tumor potentiates disease progression. However, how cells interact support progression not fully understood. Exosomes have the potential re-educate recipient through delivery their cargo, emerging as main mediators...