A5089395437- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cellular transport and secretion
- Lysosomal Storage Disorders Research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Sphingolipid Metabolism and Signaling
- Cardiomyopathy and Myosin Studies
- Insect behavior and control techniques
- Cancer-related gene regulation
- Photosynthetic Processes and Mechanisms
- Plant Physiology and Cultivation Studies
- Regulation of Appetite and Obesity
- RNA modifications and cancer
- Sleep and Wakefulness Research
- Viral Infectious Diseases and Gene Expression in Insects
- Alzheimer's disease research and treatments
- Epigenetics and DNA Methylation
- Erythrocyte Function and Pathophysiology
- Glycogen Storage Diseases and Myoclonus
- Galectins and Cancer Biology
- Neuroscience and Neuropharmacology Research
- Polydiacetylene-based materials and applications
- Synthesis and biological activity
- Protein Kinase Regulation and GTPase Signaling
- Endoplasmic Reticulum Stress and Disease
University of Aveiro
2019-2024
Universidade do Porto
2011-2019
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2019
National Institute of Health Dr. Ricardo Jorge
2013
Instituto de Biologia Molecular e Celular
2011
Centro de Genética Clínica
2007-2011
Hospital de Santa Maria
2009
A “Gramática da Língua Portuguesa” de Fernão Oliveira (1536) foi pioneira em português, comparando esse idioma ao latim e castelhano, analisando fonética, etimologia sintaxe, dessa forma se diferenciando das gramáticas latinas normativas. Sua escrita descritiva influenciou gramáticos posteriores, como João Barros. Esta obra demonstra a importância línguas nacionais no Renascimento iniciou debates sobre variação normalização, fundamentais para evolução língua portuguesa suas reformas...
Summary Saccharomyces cerevisiae cells lacking Isc1p, an orthologue of mammalian neutral sphingomyelinase 2, display a shortened lifespan and increased sensitivity to oxidative stress. A lipidomic analysis revealed specific changes in sphingolipids that accompanied the premature ageing Isc1p‐deficient under severe calorie restriction conditions, including decrease dihydrosphingosine levels increase dihydro‐C 26 ‐ceramide phyto‐C levels, latter raising possibility activation...
Boron-diketonate fluorophores, based on curcuminoid ligands, demonstrated bright emission in solution with tunable color, and were used the staining of a model fungus for fluorescence imaging.
DNA chains with sequential guanine (G) repeats can lead to the formation of G-quadruplexes (G4), which are found in functional and RNA regions like telomeres oncogene promoters. The development molecules adequate structural features selectively stabilize G4 structures counteract cell immortality, highly described for cancer cells, also downregulate transcription events underlying apoptosis and/or senescence processes. We describe here, efficiency four charged porphyrins-phosphonium...
Familial amyloidotic polyneuropathy (FAP)--Portuguese type, is an autosomal dominant related with abnormal transthyrretin (TTR Met 30). In males, the first complaint can be sexual dysfunction. Fifteen FAP patients, mean age 37 +/- 7.7 years, disease duration 5.2 2.2 all complaining of dysfunction were studied pudendal evoked potentials (PEP), bulbocavernous reflex (BCR) and sympathetic skin response (SSR). PEP BCR reflect central somatosensory pathways sacral arch functioning; SSR relates...
A fluorescent dye was decorated with water-soluble pyridinium groups in order to be applied the detection of cyclodextrins or DNA. The displays an enhancement its emission intensity when internal rotations are restricted due formation inclusion complex upon interaction In vivo, probe can stain protein aggregates a selectivity comparable widely used Proteostat®.
The identification of S-nitrosated substrates and their target cysteine residues is a crucial step to understand the signaling functions nitric oxide (NO) inside cells. Here, we show that key nitrogen metabolic enzyme glutamine synthetase (GS) S-nitrosation in Medicago truncatula characterize molecular determinants effects this NO-induced modification on different GS isoenzymes. We found all four M. isoforms are S-nitrosated, but despite high percentage amino acid identity between proteins,...
SETD7 (SET7/9, KMT7) is a lysine methyltransferase that targets master regulators of cell proliferation and differentiation. Here, the impact inhibiting catalytic activity on mammary epithelial differentiation was studied by focusing genes associated with differentiation, lactogenesis, lipid metabolism in HC11 EpH4 lines. Setd7 mRNA protein levels were induced upon lactogenic both Inhibition compound (R)-PFI-2 increased downregulated E-cadherin, beta-catenin, lactoferrin, insulin-like growth...
Pathological lipid accumulation is a hallmark of several metabolic disorders, and detection aggregates an essential step for initial diagnosis drug screening purposes. However, low-cost, simple, reliable fluorescent probes are not widely available. Here, six push-pull-push dyes were studied, proved to be highly sensitive the polarity medium, presenting potential distinguish structures with different hydrophobic indexes. Importantly, in presence their staining specificity increased...