A5048689561- Muscle activation and electromyography studies
- Nerve injury and regeneration
- Neuroscience and Neural Engineering
- Bone Tissue Engineering Materials
- Neurogenesis and neuroplasticity mechanisms
- Graphene and Nanomaterials Applications
- Dental Implant Techniques and Outcomes
- Tryptophan and brain disorders
- Photodynamic Therapy Research Studies
- Mental Health Research Topics
- Nerve Injury and Rehabilitation
- Electromagnetic Fields and Biological Effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Tissue Engineering and Regenerative Medicine
- Medical Imaging and Pathology Studies
- Geochemistry and Geologic Mapping
- Transcranial Magnetic Stimulation Studies
- Cellular Mechanics and Interactions
- Polydiacetylene-based materials and applications
- Stress Responses and Cortisol
- Microtubule and mitosis dynamics
- Occupational and environmental lung diseases
- Hemispheric Asymmetry in Neuroscience
- Heavy metals in environment
- Cell Image Analysis Techniques
University of Coimbra
2025
University of Aveiro
2011-2024
Universidad de Granada
2023-2024
Administração Regional de Saúde de Lisboa e Vale do Tejo
2023
University of Minho
2023
One of the exciting prospects using decellularized extracellular matrices (ECM) lies in their biochemical profile preserved components, many which are regeneration-permissive. Herein, a ECM from adipose tissue (adECM) was explored to design scaffolding strategy for challenging repair neural tissue. Targeting recreation nano-scaled architecture native ECM, adECM first processed into nanofibers by electrospinning produce bidimensional platforms. These were further shaped three-dimensional (3D)...
Temporomandibular disorders, of multifactorial etiology, refer to a series pathologies that affect the temporomandibular joint and associated musculature orofacial region are result alterations in physiological relationships stomatognathic system, responsible for functions such as chewing, phonation swallowing. They produce, among other symptoms, mainly pain, which affects quality life patients who suffer from them. To alleviate discomfort neuromuscular pathology region, various therapeutic...
Cosurface electrode architectures are able to deliver personalized electric stimuli target tissues. As such, this technology holds potential for a variety of innovative biomedical devices. However, date, no detailed analyses have been conducted evaluate the impact stimulator architecture and geometry on features. This work characterizes, first time, delivered bone cellular tissues during in vitro experiments, when using three capacitive architectures: stripped, interdigitated circular...
Musculoskeletal disorders are among the main causes of disease‐associated disability. Moreover, incidence and prevalence osteoporosis osteoarthritis, as well risk bone fractures need for joint replacements, expected to increase with longer life expectancy. New approaches based on electromagnetic stimulation have been developed, aiming shorten healing time, attenuate implants' osseointegration. Inductive coupling (IC), a non‐invasive methodology deliver magnetic stimuli, has reached clinical...
Boron-diketonate fluorophores, based on curcuminoid ligands, demonstrated bright emission in solution with tunable color, and were used the staining of a model fungus for fluorescence imaging.
Abstract Replacement orthopedic surgeries are among the most common worldwide, but clinically used passive implants cannot prevent failure rates and inherent revision arthroplasties. Optimized non-instrumented implants, resorting to preclinically tested bioactive coatings, improve initial osseointegration lack long-term personalized actuation on bone–implant interface. Novel bioelectronic devices comprising biophysical stimulators sensing systems thus emerging, aiming for control of...
Neural tissue-related illnesses have a high incidence and prevalence in society. Despite intensive research efforts to enhance the regeneration of neural cells into functional tissue, effective treatments are still unavailable. Here, novel therapeutic approach based on vertically aligned carbon nanotube forests (VA-CNT forests) periodic VA-CNT micropillars produced by thermal chemical vapor deposition is explored. In addition, honeycomb-like flower-like morphologies created. Initial...
Fabrication of vascularized large-scale constructs for regenerative medicine remains elusive since most strategies rely solely on cell self-organization or overly control positioning, failing to address nutrient diffusion limitations. We propose a modular and hierarchical tissue-engineering strategy produce bonelike tissues carrying signals promote prevascularization. In these 3D systems, disc-shaped microcarriers featuring nanogrooved topographical cues guide behavior by harnessing...
Bioelectronic bone implants are being widely recognized as a promising technology for highly personalized bone/implant interface sensing and biophysical therapeutic stimulation. Such bioelectronic devices based on an innovative concept with the ability to be applied wide range of implants, including in fixation prosthetic systems. Recently, biointerface using capacitive patterns was proposed overcome limitations standard imaging technologies other non-imaging technologies; moreover, electric...
Contrary to the adult central nervous system, peripheral system has an intrinsic ability regenerate that relies on expression of regeneration-associated genes, such as some kinesin family members. Kinesins contribute nerve regeneration through transport specific cargo, proteins and membrane components, from cell body towards axon periphery. We show here KIF4A, associated with neurodevelopmental disorders previously believed be only expressed during development, is also in vertebrate...
Malignant peritoneal mesothelioma (MPM) is a rare tumor of the serous membranes peritoneum and has been linked to exposure asbestos other risk factors. The clinical manifestations are vague, with wide spectrum, predominantly related abdominal involvement disease. Localized an uncommon manifestation Common symptoms include pain or distention, nausea, anorexia, weight loss. Rarely, patients present paraneoplastic syndrome. Due nonspecific symptoms, many already have advanced disease at time...
ABSTRACT Contrary to the adult central nervous system (CNS), peripheral (PNS) has an intrinsic ability regenerate that, among others, passes by expressing regeneration-associated genes such as kinesin family members. We here show that Kinesin motor protein 4a (KIF4A), associated neurodevelopmental disorders and thought for long be only embryonically expressed, is highly abundant in axons Schwann cells of rat CNS human PNS. Moreover, Kif4a up-regulated injured PNS neurons, being detected...