A5100680065- Carcinogens and Genotoxicity Assessment
- Antibiotic Resistance in Bacteria
- Microtubule and mitosis dynamics
- Enterobacteriaceae and Cronobacter Research
- Cancer-related Molecular Pathways
- Effects and risks of endocrine disrupting chemicals
- Urinary Tract Infections Management
- Air Quality and Health Impacts
- Pesticide Exposure and Toxicity
- Mosquito-borne diseases and control
- Bacterial Identification and Susceptibility Testing
- Nematode management and characterization studies
- Plant Reproductive Biology
- Invertebrate Immune Response Mechanisms
- Sesquiterpenes and Asteraceae Studies
- Cancer Genomics and Diagnostics
- Bacterial biofilms and quorum sensing
- Genomics and Chromatin Dynamics
- Plant Molecular Biology Research
- BRCA gene mutations in cancer
- Hearing, Cochlea, Tinnitus, Genetics
- Light effects on plants
- Genetic diversity and population structure
- DNA Repair Mechanisms
- Biochemical effects in animals
Daejeon Institute of Science and Technology
2022-2024
Washington State University
2024
Pukyong National University
2020
Hanseo University
2020
Korea Occupational Safety and Health Agency
2011-2018
Children's Healthcare of Atlanta
2017
Emory University
2014-2017
Medical Research Council
2004-2014
Hutchison/MRC Research Centre
2004-2014
University of Cambridge
2014
Germ-line mutations inactivating BRCA2 predispose to cancer. BRCA2-deficient cells exhibit alterations in chromosome number (aneuploidy), as well structurally aberrant chromosomes. Here, we show that deficiency impairs the completion of cell division by cytokinesis. inactivation murine embryo fibroblasts (MEFs) and HeLa targeted gene disruption or RNA interference delays prevents cleavage. Impeded separation is accompanied abnormalities myosin II organization during late stages may have a...
Centrosomes ensure accurate chromosome segregation by directing spindle bipolarity. Loss of centrosome regulation results in amplification, multipolar mitosis and aneuploidy. Since amplification is common premalignant lesions breast tumors, it proposed to play a central role tumorigenesis, hypothesis that remains be tested. The coordination between the cell cycles paramount importance maintain normal numbers, E2Fs may responsible for regulating these cycles. However, E2F activators unclear....
Centrosome amplification (CA) amongst particular breast cancer subtypes (Her2+ subtype) is associated with genomic instability and aggressive tumor phenotypes. However, changes in signaling pathways centrosome biology have not been fully explored subtype specific models. Novel regulatory genes that are selectively altered Her2+ cells of interest discerning why CA more prevalent this subtype. To determine centrosome/cell cycle display (HCC1954) versus non-tumorigenic (MCF10A), we carried out...
The arbovirus West Nile virus (WNV) is a danger to global health. Spread primarily by mosquitoes, WNV causes about 2000 cases per year in the United States. natural mosquito immune response controls viral replication so that host survives but can still transmit virus. Using genetically malleable Drosophila melanogaster model, we previously dissected innate pathways used control infection. Specifically, showed insulin/IGF-1 signaling (IIS) activates JAK/STAT-mediated reduces WNV. However, how...
Previous studies have shown that biomarkers of chemicals with long half-lives may be better surrogates exposure for epidemiological analyses, leading to less attenuation the exposure-disease association, than personal air samples. However, short inconsistent results. In present study, we compared pairs benzene and its short-half-life urinary metabolite trans,trans-muconic acid (t,t-MA), predicted bias theoretical association. Total 669 urine t,t-MA samples were taken from 474 male workers...
Defects in the completion of cell division by cytokinesis have long been proposed to foster carcinogenesis engendering chromosome instability, but few tumor suppressor mechanisms controlling this process so far identified. Here, we identify a carboxyl (C)-terminal region high-mobility group protein HMG20b that is essential for cytokinesis, and report it inactivated cancer-associated mutation. We find C-terminal spanning residues 173–317 necessary sufficient not only its localization...
Dieldrin, one of the organochlorine pesticides(OCPs), induced damages in neuroblastoma cells and DNA lymphocytes. The ethanol extracts A. sessiliflorus leaves were examined for suppressive effects on dieldrin-induced cell damages. Moreover, extract was used to test whether it might inhibit oxidative damage lymphocytes using Comet assay. by dieldrin suppressed vitro upon treating. extract. This result suggests that be useful reduce toxicity.
Background A lineage of Klebsiella pneumoniae that produces carbapenemase-2 (KPC-2), sequence type (ST) 307, emerged in 2017. We analyzed the complete sequences plasmids from KPC-2-producing K. (KPC-Kp) ST307, investigated antimicrobial resistance conferred by this strain, and confirmed horizontal interspecies transmission KPC-carbapenemase-producing Enterobacteriaceae (CPE) characteristics among Enterobacteriaceae. Methods performed susceptibility testing, PCR analysis, multilocus typing,...
This study was designed to provide logical backgrounds for the revision of biological exposure indices (BEIs) styrene in Korea. In order investigate correlation between airborne and indices, we measured urinary mandelic acid (MA) phenylglyoxylic (PGA) workers exposed occupationally, as well at workplaces.Surveys were conducted 56 subjects. The concentrations metabolites 36 who occupationally styrene, 20 controls. Air samples collected using personal air samplers analyzed by gas...
In this study, we summarized the External Quality Assessment Scheme (EQAS) for biological monitoring of occupational exposure to toxic chemicals which started in 1995 and continued until a 31(st) round robin spring 2010. The program was performed twice per year 2009, changed once since objective is ensure reliability data related from analytical laboratories.One hundred eighteen laboratories participated robin. offers 5 items inorganic analysis: lead blood, cadmium manganese urine, mercury...
Abstract Despite findings reported by The Cancer Genome Atlas (TCGA) that the most common human tumors have undergone at least one genomic doubling, roles of polyploidy and chromosome instability (CIN) in cancer are poorly understood. Defective mitosis, centrosome amplification (CA) major sources CIN, which generally associates with poor prognosis patients. Prevalence CA CIN hormone receptor negative (ER-PR-Her2- or ER-PR-Her2+) breast patients, who poorest outcomes among all intrinsic...
Abstract Photorhabdus insect-related PirA vp (where stands for Vibrio parahaemolyticus ) and PirB of were expressed in Escherichia coli , designated rPirA rPirB respectively, then tested on 4 crustaceans via immersion tests. toxin was detected from 2 h after incubation accumulated with bacterial growth. The culture filtrate 15 nM caused 100% mortality Litopenaeus vannamei within days immersion. showed at 7 purified or + mixture. cumulative mortalities the mixture 50, 83 Macrobrachium...