A5007940827- Clusterin in disease pathology
- Ferroptosis and cancer prognosis
- Thyroid Cancer Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Glycosylation and Glycoproteins Research
- Signaling Pathways in Disease
- Advanced Proteomics Techniques and Applications
- Carbohydrate Chemistry and Synthesis
- Natural product bioactivities and synthesis
- Extracellular vesicles in disease
- Sesquiterpenes and Asteraceae Studies
- Heat shock proteins research
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Galectins and Cancer Biology
- Platelet Disorders and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Monoclonal and Polyclonal Antibodies Research
- Cancer Research and Treatments
- Herbal Medicine Research Studies
- Iron Metabolism and Disorders
- Tannin, Tannase and Anticancer Activities
- Ubiquitin and proteasome pathways
- Selenium in Biological Systems
Chulabhorn Research Institute
2017-2024
Ministry of Public Health
2012
Department of Medical Sciences
2012
Osaka University
2011
Due to the invasive procedure associated with Pap smears for diagnosing cervical cancer and conservative culture of developing countries, identifying less biomarkers is great interest. Quantitative label‑free mass spectrometry was performed identify potential in urine samples patients cancer. This technique used study differential expression urinary proteomes between normal individuals patients. The alterations levels were analyzed by Progenesis software results revealed that 60 proteins...
Colorectal cancer (CRC) is a major cause of mortality. Currently used CRC biomarkers provide insufficient sensitivity and specificity; therefore, novel are needed to improve the detection. Label-free quantitative proteomics were identify compare glycoproteins, enriched by wheat germ agglutinin, from plasma patients age-matched healthy controls. Among 189 identified levels 7 15 glycoproteins significantly altered in non-metastatic metastatic groups, respectively. Protein-protein interaction...
The northeastern region of Thailand is well known to have a high incidence and mortality cholangiocarcinoma (CCA). Protein phosphorylation status has been reported reflect key determinant cellular physiology, but identification phosphoproteins can be problem due the presence phosphatase. Exosomes are stable toward circulating proteases other enzymes in human blood recognized before onset cancer progression. Here an vitro metastatic model isogenic CCA cells used provide insight into levels...
Colorectal cancer (CRC) is one of the major causes cancer-related death worldwide. Although commercial biomarkers CRC are currently available, they still lacking in terms sensitivity and specificity; thus, searching for reliable blood-based important primary screening CRC.Plasma samples patients with non-metastatic (NM) metastatic (M) healthy controls were fractionated using MARS-14 immunoaffinity chromatography. The flow-through elute fractions representing low- high-abundant proteins,...
Due to drug resistance and disease recurrence, lung cancer remains one of the primary cancer‑related causes death in both men women worldwide. In addition, is clinically silent thus most patients are at an advanced stage time diagnosis. The limited efficiency current conventional chemotherapies necessitates search for novel effective anticancer agents. present study demonstrated anti‑proliferative effect apoptosis‑inducing activity three sesquiterpene lactones isolated from Gymnanthemum...
Cholangiocarcinoma (CCA), derived from the bile duct, occurs with a relatively high incidence in Northeast Thailand. Early diagnosis is still hampered by lack of sufficient biomarkers. In recent years, biomarker discovery using secretomes has provided interesting results, including our studies on CCA secretomes, especially three-dimensional cell cultures. Thus, cells cultured hollow fiber bioreactor (HFB) 20 kDa molecular weight cut-off (MWCO) yielded higher quality and quantity than those...
Protein O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a dynamic post-translational modification process that plays an essential role in biological activities. Growing evidence indicates aberration of O-GlcNAcylation associated with various diseases, e.g. diabetes, neurological and cancers. However, the mechanistic studies are lagging behind other modifications due to its extremely low abundance, limited analytical tools, specificity. Herein, diagonal strong cation exchange...
Highly active antiretroviral (ARV) therapy has successfully reduced viral transmission, morbidity, and mortality associated with human immunodeficiency virus type 1 (HIV-1) disease; however, the emergence of drug-resistant viruses is a major obstacle ARV therapy. Therefore, development new class drugs urgently required. Cyclophilin A (CypA) host factor required for HIV-1 replication, plays role in replication by interacting capsid protein (CA). As such, it represents potential target novel...
Background: Currently available antiretroviral drugs are classified into 4 classes including reverse transcriptase inhibitors, protease integrase inhibitors and entry/fusion inhibitors. Highly active therapy (HAART), using a combination of three or more drugs, can manage HIV-1 replication for many years; however, the virus tries to survive under by mutate itself become drug-resistant variant. Therefore, development new anti-HIV-1 with different inhibition mechanisms is required. The...
Background/Aim: Lung cancer is the leading cause of death worldwide. Cigarette smoke most important risk factor for development. Growing evidence indicates that prolonged nicotine exposure a potential associated with tumorigenesis. Here, effect on A549 cells was investigated, using label-free quantitative proteomics. Materials and Methods: Selection an invasive subpopulation from cell line performed to reveal differential expression proteins in relation exposure, Boyden chamber assays...