A5072517998- Genetic Syndromes and Imprinting
- Fibroblast Growth Factor Research
- Parathyroid Disorders and Treatments
- Flood Risk Assessment and Management
- Hydrology and Watershed Management Studies
- Epigenetics and DNA Methylation
- Folate and B Vitamins Research
- Integrated Water Resources Management
- Hormonal Regulation and Hypertension
- Hydrology and Sediment Transport Processes
- Prenatal Screening and Diagnostics
Vanderbilt University Medical Center
2022-2025
University of Vermont
2022
Hypertension Institute
2022
Acute and chronic kidney injuries induce increased cell cycle progression in renal tubules. While promotes repair after acute injury, the role of ongoing tubular disease is unknown. Two weeks initiation disease, we blocked at G1/S phase by using an FDA-approved, selective inhibitor CDK4/6. Blocking CDK4/6 improved function reduced injury fibrosis 2 murine models disease. However, deletion cyclin D1, which complexes with to promote progression, paradoxically injury. Expression quantitative...
Background: Genome-wide association studies (GWAS) have identified numerous genetic loci associated with mineral metabolism markers but exclusively focused on single-trait analysis. In this study, we performed a multi-trait analysis of GWAS (MTAG) metabolism, exploring overlapping architecture between traits to identify novel associations for fibroblast growth factor 23 (FGF23). Methods: We applied MTAG variants common 5 genetically correlated in European-ancestry participants. integrated UK...
Elevated fibroblast growth factor-23 (FGF23) has been consistently associated with heart failure, particularly failure preserved ejection fraction, among patients CKD and in the general population. FGF23 may directly induce cardiac remodeling failure. However, biases affecting observational studies impede robust causal inferences. Mendelian randomization leverages genetic determinants of a risk factor to examine causality. We performed two-sample assess associations between failure.Genetic...
Abstract Floodplain reconnection projects are largely nature‐based solutions that have great potential to restore channel stability, attenuate stormwater, improve flood resilience, and water quality. The suite of possible restoration options for a given study area must consider the multiple uses functions river corridors, along with impacts benefits adjacent infrastructure. Therefore, decision‐support frameworks designed help stakeholders compare floodplain scenarios best meet site‐specific...
ABSTRACT Background Genome-wide association studies (GWAS) have identified numerous genetic loci associated with mineral metabolism (MM) markers but exclusively focused on single-trait analysis. In this study, we performed a multi-trait analysis of GWAS (MTAG) MM, exploring overlapping architecture between traits, to identify novel associations for fibroblast growth factor 23 (FGF23). Methods We applied MTAG variants common 5 genetically correlated MM (calcium, phosphorus, FGF23,...