A5103217089- Genetics, Aging, and Longevity in Model Organisms
- T-cell and Retrovirus Studies
- Antimicrobial Peptides and Activities
- Insect-Plant Interactions and Control
- RNA and protein synthesis mechanisms
- Circadian rhythm and melatonin
- Animal Nutrition and Physiology
- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
- Retinal Development and Disorders
- Pharmacological Effects of Natural Compounds
- Genetic and phenotypic traits in livestock
- Bacterial Genetics and Biotechnology
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Animal Genetics and Reproduction
- Genetic Mapping and Diversity in Plants and Animals
- Reproductive Biology and Fertility
- Phytoestrogen effects and research
- CRISPR and Genetic Engineering
- Drug-Induced Ocular Toxicity
- Retinal Diseases and Treatments
- Ginseng Biological Effects and Applications
- Plant and animal studies
- Effects of Radiation Exposure
University of Massachusetts Chan Medical School
2018-2020
Kangwon National University
2015
Seoul National University
1997-2008
Boston University
1994-1995
Cancer Research Center
1995
Ethambutol is a useful first line antituberculous drug, but can cause significant visual impairment. In order to determine the clinical manifestations of optic neuropathy associated with ethambutol, and margin drug safety in Koreans, we investigated ten men four women, diagnosed between 1995 1997 at Seoul Municipal Boramae Hospital as suffering from ethambutol toxicity. After determining their history, including period during which had been administered, its dose, complete eye examination...
Type C RNA leukemia viruses cause lymphoid neoplasia after an extended latent period by unknown mechanism. Infection of human or murine cells with rapidly increases the expression genes belonging to immunoglobulin superfamily and involved in T-lymphocyte activation, including class I major histocompatibility complex antigens. We report here that long terminal repeat (LTR) Moloney virus encodes a novel trans-activator, which induces transcription genes. The portion LTR responsible for...
ABSTRACT C. elegans heterochronic genes determine the timing of expression specific cell fates in particular stages developing larvae. However, their broader roles coordinating developmental events across diverse tissues have been less well investigated. Here, we show that loss lin-28, a central regulator hypodermal development, causes reduced fertility associated with abnormal somatic gonadal morphology. In particular, spermatheca-uterine valve morphology lin-28(lf) hermaphrodites traps...
Infection of human or murine cells with leukemia viruses rapidly increases the expression a number genes that belong to immunoglobulin superfamily and are involved in T-lymphocyte activation, including class I major histocompatibility complex antigens. We have reported recently long terminal repeat (LTR) Moloney virus encodes trans activator which induces transcription certain cytokine genes. The portion LTR responsible for activation was mapped by deletions lie within U3 region. demonstrate...
The study was designed to investigate genetic associations of single nucleotide polymorphism (7 SNPs located on 7 selected candidate genes) with growth and meat quality F1 Korean native pig × Duroc. Selected SNP sets (7) 86 crossbred samples were genotyped by PCR-RFLP. association analysis revealed that MC4R, PGK2 CTSD genes significantly associated body weight. Average daily gain at 2 weeks (ADG2) showed significant MC4R PGK2. On the other hand, ADG10 only MC4R. In addition, backfat...
Abstract C. elegans heterochronic genes determine the timing of expression specific cell fates in particular stages developing larva. However, their broader roles coordinating developmental events across diverse tissues has been less well investigated. Here, we show that loss lin-28 , a central regulator hypodermal development, causes reduced fertility associated with abnormal somatic gonad morphology. In particular, spermatheca-uterine valve morphology lin-28(lf) hermaphrodites trap embryos...