A5075400210- Ion channel regulation and function
- Bacillus and Francisella bacterial research
- Nicotinic Acetylcholine Receptors Study
- Phagocytosis and Immune Regulation
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Pain Mechanisms and Treatments
Harvard University
2020-2021
Bacterial products are able to act on nociceptive neurons during pathogenic infection. Neurogenic inflammation is an active part of pain signaling and has recently been shown impact host-pathogen defense. Bacillus anthracis Edema Toxin (ET) produces striking edema in peripheral tissues, but the cellular mechanisms involved tissue swelling not completely understood. Here, we find that play a role ET-induced mice. Subcutaneous footpad infection B. Sterne caused ET-dependent local mechanical...
ABSTRACT Bacterial toxins are able to act on neurons modulate signaling and function. Here, we find that nociceptive sensory mediate pain enriched in the receptor for anthrax toxins, ANTXR2. Anthrax Edema Toxin (ET) induced cAMP PKA Nav1.8 + modulated vivo . Peripherally administered ET mediated mechanical allodynia naïve mice during B. anthracis infection. Intrathecally produced analgesic effects, potently blocking pain-like behaviors multiple mouse models of inflammatory chronic...