A5001457923- Prostate Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Prostate Cancer Treatment and Research
- Economic and Financial Impacts of Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Bladder and Urothelial Cancer Treatments
- Advances in Oncology and Radiotherapy
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Management of metastatic bone disease
- Global Cancer Incidence and Screening
- Lung Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Statistical Methods in Clinical Trials
- Multiple and Secondary Primary Cancers
- Radiomics and Machine Learning in Medical Imaging
- Radiation Dose and Imaging
- Lung Cancer Treatments and Mutations
- Breast Cancer Treatment Studies
- Urinary and Genital Oncology Studies
- Medical Imaging Techniques and Applications
- Urological Disorders and Treatments
- Immunotherapy and Immune Responses
- Healthcare Policy and Management
- Neurofibromatosis and Schwannoma Cases
University of Kansas Medical Center
2016-2025
The University of Kansas Cancer Center
2013-2024
Mali-Folkecenter
2022
University of Kansas
2013-2019
University Medical Center
2018
Thomas Jefferson University
2009-2014
Princess Margaret Cancer Centre
2014
University of Maryland, Baltimore
2014
Sidney Kimmel Cancer Center
2009-2013
Albert Einstein College of Medicine
2013
Abstract Recent studies have indicated that adoptive immunotherapy with autologous antitumor tumor-infiltrating lymphocytes (TILs) following nonmyeloablative chemotherapy mediates tumor regression in ∼50% of treated patients metastatic melanoma, and is correlated the degree persistence adoptively transferred T cells peripheral blood. These findings, which suggested proliferative potential may play a role clinical responses, led to current telomere length as well phenotypic markers expressed...
To study the steps in differentiation of human memory CD4 T cells, we characterized functional and lineage relationships three distinct subpopulations distinguished by their expression cysteine chemokine receptor CCR7 TNFR family member CD27. Using combination these phenotypic markers, populations were defined: CCR7+CD27+, CCR7-CD27+, CCR7-CD27- population. In vitro stimulation led to a stepwise from naive CCR7+CD27+ CCR7-CD27+ CCR7-CD27-. Telomere length subsets differed significantly...
Transfer of autologous tumor-specific tumor infiltrating lymphocytes (TILs) in adoptive immunotherapy can mediate the regression patients with metastatic melanoma. In this procedure, TILs from resected tumors are expanded vitro, then administered to and further stimulated proliferate vivo by administration high dose IL-2. After vitro expansion, often dominated a few specific clonotypes, recently it was reported that persistence one or more these clonotypes correlated positive therapeutic...
The chemokine receptor CCR7 and the tumor necrosis factor family member CD27 define 3 distinct, progressively more differentiated maturational stages of CD4 memory subpopulations in healthy individuals: CCR7+, CD27+, CCR7-, CD27- populations. goal this study was to examine disturbances T cell differentiation systemic lupus erythematosus (SLE), using these phenotypic markers.Phenotypic analysis by flow cytometry, vitro stimulation experiments, telomere length measurement, determination...
Abstract BACKGROUND: Glioblastoma multiforme (GBM) is the most frequent primary brain tumor in adults. Temozolomide was rapidly incorporated into first‐line treatment following publication of pivotal European Organization for Research and Treatment Cancer–National Cancer Institute Canada phase 3 trial 2005. However, trial, enrollment limited to younger patients with good performance status. Therefore, this study performed a population‐based survival analysis newly diagnosed GBM covering...
4500 Background: Trastuzumab is a monoclonal antibody against human epidermal growth factor receptor 2 (HER2). The primary objective of RTOG 1010 was to determine if trastuzumab increases disease-free survival (DFS) when combined with trimodality treatment for patients HER2 overexpressing esophageal adenocarcinoma. Methods: This open label, randomized phase III trial included newly diagnosed stage T1N1-2, T2-3N0-2 adenocarcinoma the esophagus involving mid, distal, or esophagogastric...
To test the feasibility of sleep hygiene education and longitudinal wrist actigraph metrics measurement alone versus in combination with telehealth-delivered cognitive behavioral therapy for insomnia (teleCBT-I) people prostate cancer (PC) receiving androgen deprivation (ADT). 45 men PC ADT were recruited from a midwestern comprehensive center. Participants provided actigraphs, their individual data, education. Half sample was randomized to four-week teleCBT-I intervention. Outcomes...
Primary pancreatic lymphoma (PPL) is a rare disease, accounting for only 0.5% of all masses. A paucity literature exists on the epidemiology and outcomes PPL. Here, we present series 523 cases PPL obtained from Surveillance, Epidemiology, End Results database.Patients diagnosed with 1973 to 2007 were identified. Data patient tumor characteristics as well initial treatment surgery or radiation extracted. Survival rates calculated using Kaplan-Meier method. multivariate analysis was performed...
Adjuvant radiation therapy (RT) with temozolomide (TMZ) is standard of care for high grade gliomas (HGG) patients. RT commonly started 3 to 5 weeks after surgery. The deformation the tumor bed and brain from surgery poorly studied. This study examined magnitude volume change in postoperative potential impact planning. includes 24 patients HGG who underwent craniotomy adjuvant TMZ at our institution. All had immediate MRI repeat during day simulation. Gross volumes (GTV), clinical target...
With rising costs of diagnosis, treatment, and survivorship, financial burdens on cancer patients negative effects from high costs, called toxicity (FT), are growing. Research suggests that FT may be experienced by over half working-age survivors, a similar proportion incur debt or avoid recommended prescription medications due to treatment costs. As can lead worse physical, psychological, financial, survival outcomes, there is discrete need identify research gaps around this issue constrain...
We evaluated long-term changes in the volume and payments for radiation oncology services intensity-modulated therapy (IMRT) era from 2000 to 2010 using a database of Medicare claims.We used Physician/Supplier Procedure Summary Master File (PSPSMF) each year tabulate services. This provides summary billing code submitted part B. identified all codes categorized by treatment modality place service.We focused our analysis on office-based practices. Total patient increased 8.2% 2010, whereas...
8513 Background: In advanced non-small cell lung cancer (NSCLC), high Programmed-Death-1 Ligand (PD-L1) (>50%) expression demonstrate superior response and survival with immune checkpoint inhibitors compared to chemotherapy. We hypothesize that it is safe feasible substitute durvalumab instead of chemotherapy concurrently radiotherapy (RT) in patients Locally Advanced-NSCLC (LA-NSCLC) PD-L1. Methods: NRG-LU004 (NCT03801902) a Phase I study for stage II-III unresectable or inoperable,...
Fractionated stereotactic radiotherapy (FSRT) is a noninvasive treatment for acoustic neuromas (ANs). Initial reports from our institution demonstrated that the reduction of dose to 46.8 Gy resulted in improved preservation functional hearing status.We now report tumor control (TC), symptomatic outcome, and (HP) rate patients treated with reduced-dose FSRT.We analyzed all AN 2002 2011. All received 1.8-Gy fractions. Follow-up audiogram magnetic resonance imaging were performed ≤ 1-year...
Head and neck surgery radiation cause tissue fibrosis that leads to functional limitations lymphedema. The objective of this study was determine whether lymphedema therapy after for head cancer decreases circumference, increases cervical range motion, improves pain scores.A retrospective review all patients with squamous cell carcinoma the oral cavity, oropharynx, or larynx who were treated high-dose at a single center between 2011 2012 performed. Patients received definitive postoperative...
131 Background: Patients with high-risk features who experience biochemical relapse (BCR) after radical prostatectomy (RP) benefit from the addition of androgen deprivation therapy (ADT) to salvage radiotherapy (SRT). We hypothesized that intensification receptor (AR) blockade enzalutamide would improve SRT outcomes for patients. Methods: Post prostate cancer patients have had BCR (PSA ≥ 0.2 ng/mL) at least 1 feature (Gleason 8-10, seminal vesicle invasion, pN1, persistent PSA >0.1 ng/mL...
Abstract Objective. Hybrid proton-photon radiotherapy (RT) is a cancer treatment option to broaden access proton RT. Additionally, with refined planning method, hybrid RT has the potential offer superior plan quality compared proton-only or photon-only RT, particularly in terms of target coverage and sparing organs-at-risk (OARs), when considering robustness setup range uncertainties. However, there concern regarding underestimation biological effect protons on OARs, especially those close...