A5071942279- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Advanced Radiotherapy Techniques
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Endometrial and Cervical Cancer Treatments
- Sarcoma Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Treatments and Studies
- Ovarian cancer diagnosis and treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiation Therapy and Dosimetry
- Lung Cancer Diagnosis and Treatment
- Management of metastatic bone disease
- Cervical Cancer and HPV Research
- Medical Imaging Techniques and Applications
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Cancer Genomics and Diagnostics
- Bone Tumor Diagnosis and Treatments
- Renal cell carcinoma treatment
- Radiomics and Machine Learning in Medical Imaging
- Bladder and Urothelial Cancer Treatments
- Vascular Tumors and Angiosarcomas
Mayo Clinic in Arizona
2016-2025
Mayo Clinic
2016-2025
WinnMed
2007-2023
Mayo Clinic in Florida
2012-2023
Radiation Oncology Associates
1999-2022
Thomas Jefferson University Hospital
2020
Greater Poland Cancer Center
2013
Oregon Health & Science University
2011-2012
Dana-Farber Cancer Institute
2006-2012
RTOG Foundation
2009-2012
Among patients with locally advanced metastatic pancreatic adenocarcinoma, gemcitabine has been shown to improve outcomes compared fluorouracil.To determine if the addition of adjuvant fluorouracil chemoradiation (chemotherapy plus radiation) improves survival for resected adenocarcinoma.Randomized controlled phase 3 trial complete gross total resection adenocarcinoma and no prior radiation or chemotherapy enrolled between July 1998 2002 follow-up through August 18, 2006, at 164 US Canadian...
Compare survival after neoadjuvant therapy and liver transplantation with resection for patients hilar CCA.
Purpose On initial publication of GI Intergroup Radiation Therapy Oncology Group (RTOG) 98-11 [A Phase III Randomized Study 5-Fluorouracil (5-FU), Mitomycin, and Radiotherapy Versus 5-Fluorouracil, Cisplatin in Carcinoma the Anal Canal], concurrent chemoradiation (CCR) with fluorouracil (FU) plus mitomycin (MMC) decreased colostomy failure (CF) when compared induction FU cisplatin (CDDP), but did not significantly impact disease-free survival (DFS) or overall (OS) for anal canal carcinoma....
Orthotopic liver transplantation (OLT) alone for unresectable cholangiocarcinoma is often associated with early disease relapse and limited survival. Because of these discouraging results, most programs have abandoned OLT cholangiocarcinoma. However, a small percentage patients achieved prolonged survival after OLT, suggesting that adjuvant approaches could perhaps improve the outcome. Based on concepts, protocol was developed at Mayo Clinic using preoperative irradiation chemotherapy We...
To assess the results of multimodality therapy for patients with recurrent rectal cancer and to analyze factors predictive curative resection prognostic overall survival.Locally is a difficult clinical problem, radical treatment options intent are not generally accepted.A total 394 underwent surgical exploration cancer. Ninety were found have unresectable local or extrapelvic disease 304 recurrence. The latter prospectively followed determine long-term survival influencing survival.Overall...
To determine prognostic factors and impact of adjuvant chemotherapy (CT) radiotherapy (RT) on overall survival (OS) after resection pancreatic adenocarcinoma.We performed a retrospective review 472 consecutive patients who underwent complete with negative margins (R0) for invasive carcinoma (T1-3N0-1M0) the pancreas between 1975 2005 at Mayo Clinic in Rochester, MN. Exclusion criteria included metastatic or unresectable disease surgery, positive surgical margins, indolent tumor types (islet...
Patients with unresectable, stage I and II perihilar cholangiocarcinoma were treated neoadjuvant external beam irradiation, brachytherapy, 5-fluorouracil and/or oral capecitabine prior to liver transplantation. Fifty-six patients underwent treatment between 1993 2003. Four died 4 had disease progression completion of therapy. Forty-eight operative staging 14 findings precluding Twenty-eight transplantation 6 are awaiting Three from perioperative complications, developed recurrent 22 63...
Survival for pancreatic ductal adenocarcinoma is low, the role of adjuvant therapy remains controversial, and recent data suggest chemoradiation (CRT) may decrease survival compared with surgery alone. Our goal was to examine efficacy CRT in resected Patients at Johns Hopkins Hospital (n = 794, 1993–2005) Mayo Clinic 478, 1985–2005) following resection who were observed 509) or received 5-FU based (median dose 50.4 Gy; n 583) included. Cox propensity score analyses assessed associations...
Sixty-five patients with unresectable hilar cholangiocarcinoma (CCA) have undergone orthotopic liver transplantation (OLT) after neoadjuvant chemoradiotherapy per a clinical care protocol developed in 1993. We reviewed our experience the aim to identify clinicopathological predictors of disease recurrence.All CCA that underwent OLT at institution between 1993 and January 1, 2006 were treated accord published protocol. analyzed multiple explant pathologic factors using Cox regression...
Only 4 prospective randomized phase 3 trials have been reported for anal cancer. A prognostic factor analysis cancer from a database has published only 1 study (N = 110). To confirm and uncover new factors, we analyzed the of intergroup RTOG 98-11.Univariate multivariate analyses baseline characteristics 5-year overall survival (OS) disease-free (DFS) were carried out. Various combinations tumor diameter clinically positive nodes (N(+)) to identify subgroups.A total 644 assessable analyzed....
To report single-institutional clinical outcomes and toxicity with SBRT for cholangiocarcinoma.From March 2009 to July 2011, 10 patients 12 unresectable primary (n = 6) or recurrent cholangiocarcinoma lesions underwent abdominal SBRT. Sites treated included liver 10), lymph nodes 1), adrenal gland 1). was delivered in three 2) five 10) consecutive daily fractions over one week. The median prescription dose 55 Gy (range, 45-60). Treatment response graded by RECIST v.1.1, toxicities were...
Grade 4 lymphopenia (G4L) during radiation therapy (RT) is associated with higher rates of distant metastasis and decreased overall survival in a number malignancies, including esophageal cancer (EC). Through reduction integral dose, proton RT (PRT) may reduce G4L relative to photon (XRT). The purpose this study was compare patients EC undergoing PRT versus XRT.Patients receiving curative-intent concurrent chemotherapy for were identified. Lymphocyte nadir defined as the lowest lymphocyte...
Background: Neoadjuvant therapy (NAT) is used in borderline resectable/locally advanced (BR/LA) pancreatic ductal adenocarcinoma (PDAC). Anatomic imaging (CT/MRI) poorly predicts response, and biochemical (CA 19-9) markers are not useful (nonsecretors/nonelevated) many patients. Pathologic response highly survival post-NAT, but only known postoperatively. Because metabolic (FDG-PET) reveals primary tumor viability, this study aimed to evaluate our experience with preoperative FDG-PET...
This analysis was performed to examine the outcome of patients with histologically confirmed central neurocytomas.Thirty-two neurocytomas were evaluated retrospectively. Patients treated various combinations surgery, chemotherapy, and radiotherapy (RT). Follow-up ranged from 2.3 15.3 years (median, 4.7 years).The overall 5-year survival local control rates 81% 79%, respectively. No patient developed metastases. The rate 70% for undergoing subtotal resection (STR) 100% those gross total (GTR)...
BACKGROUND This study examined the outcome of patients with histologically confirmed pineal region tumors. METHODS One hundred thirty-five tumors and other germ cell brain were evaluated retrospectively. The parenchymal (PPTs) included 15 pineoblastomas (PB), 2 mixed PPTs, 4 PPTs intermediate differentiation, 9 pineocytomas. 48 germinomas, 26 tumors, 11 mature teratomas, immature 6 malignant yolk sac 3 choriocarcinomas. Patients treated various combinations chemotherapy, radiotherapy,...