A5025688956- Neuroinflammation and Neurodegeneration Mechanisms
- Reproductive System and Pregnancy
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Endoplasmic Reticulum Stress and Disease
- Muscle metabolism and nutrition
- Pregnancy and preeclampsia studies
- Retinal Diseases and Treatments
- Nerve injury and regeneration
- Cell Adhesion Molecules Research
- Reproductive Biology and Fertility
- Glaucoma and retinal disorders
- Birth, Development, and Health
- Genetics and Physical Performance
- Atherosclerosis and Cardiovascular Diseases
- Axon Guidance and Neuronal Signaling
- Tannin, Tannase and Anticancer Activities
- Cellular transport and secretion
- Calpain Protease Function and Regulation
- Transgenic Plants and Applications
- Cardiovascular and exercise physiology
- Genetics, Aging, and Longevity in Model Organisms
- Chemokine receptors and signaling
- Cardiovascular Effects of Exercise
- COVID-19 Impact on Reproduction
Gunma University
2023
Tohoku University
2014-2020
Institute for Multidisciplinary Research
2017
Osaka Medical Center for Cancer and Cardiovascular Diseases
2007-2011
Chubu National Hospital
2002-2004
Yamaguchi University
1996-2004
Nagoya University
2004
University of Tsukuba
2002
SAGA Light Source
2000
Tokiwa Park
1996
Abstract T cells that encounter ocular pigment epithelium in vitro are inhibited from undergoing TCR-triggered activation, and instead acquire the capacity to suppress activation of bystander cells. Because retinal epithelial (RPE) cell by releasing soluble inhibitory factors, we studied whether factors also promote generation regulatory (Treg) We found RPE converted CD4+ into Treg producing secreting CTLA-2α, a cathepsin L (CathL) inhibitor. Mouse rCTLA-2α vitro, CTLA-2α small interfering...
Abstract Glaucoma is a group of eye diseases characterized by alterations in the contour optic nerve head (ONH), with corresponding visual field defects and progressive loss retinal ganglion cells (RGCs). This RGC death considered to originate axonal injury caused compression axon bundles ONH. However, molecular pathomechanisms injury-induced are not yet well understood. Here, we used RNA sequencing (RNA-seq) examine transcriptome changes rat retinas 2 days after transection (ONT) then...
Pigment epithelium isolated from the eye possesses immunosuppressive properties such as regulatory T (Treg) cell induction; e.g., cultured retinal pigment (RPE) converts CD4(+) cells into Treg in vitro. RPE constitutively expresses a novel factor, CTLA-2alpha, which is cathepsin L (CathL) inhibitor, and this molecule acts via to induce cells. To clarify CTLA-2alpha's role response ocular inflammation, we used experimental autoimmune uveitis (EAU) animal model examine new property of RPE. In...
The genetic difference among individuals partly explains variance in adaptive response to exercise through gene-environment interaction. aim of this cross-sectional study was evaluate the role vitamin D receptor (VDR) gene polymorphism, which locates at translation initiation site, adaptations bone long-term impact loading. VDR genotypes, as detected by endonuclease Fok I, and phenotypes lumbar spine femoral neck were examined 44 highly trained young male athletes age-matched nonathletic...
Purpose.: To determine whether murine corneal endothelial (CE) cells can promote the generation of T regulatory (Treg) in vitro. Methods.: induce Treg vitro by CE cell lines, exposed to were used as cells. presence anti–mouse CD3 antibody harvested and added target bystander T-cell activation was assessed for proliferation [3H]-thymidine incorporation. Expression CD25 or Foxp3 on evaluated flow cytometry. cytotoxic T-lymphocyte antigen-2 alpha (CTLA-2α) cytometry, RT-PCR,...
Artemin, a recently discovered member of the glial cell line‐derived neurotrophic factor (GDNF) family, has effects on damaged neurons, including sympathetic dopamine and spiral ganglion neurons both in vivo vitro. However, its retinal cells intracellular signaling remain relatively unexplored. During development, expression GFRα3, specific receptor for artemin, is strong immature retina gradually decreases during maturation, suggesting possible role formation connections. Optic nerve damage...
Significance Multidomain proteins constitute more than two-thirds of all proteome. To decrease the risk misfolding, these generally fold vectorially as each domain emerges from ribosome or protein translocation channel. Interestingly, however, some cell surface multidomain including low-density lipoprotein receptor (LDLR) in ER nonvectorially via intermediates with nonnative disulfides. Shuffling disulfides to native ones, a key step their folding, has been thought proceed slowly after...
To investigate the effect of bilberry extract anthocyanins on retinal ganglion cell (RGC) survival after optic nerve crush. Additionally, to determine details mechanism neuroprotective and involvement endoplasmic reticulum stress suppression in mouse retina.Anthocyanins (100 mg/kg/day or 500 mg/kg/day) were administrated orally C57BL/6J mice. The expression levels various molecular chaperones assessed with quantitative reverse-transcription polymerase chain reaction, Western blotting,...
To examine the effects of physical training on glucose effectiveness (S G ), insulin sensitivity I and endogenous production (EGP) in middle-aged men, stable-labeled frequently sampled intravenous tolerance tests (FSIGTT) were performed 11 exercise-trained men 12 age-matched sedentary men. The time course EGP during FSIGTT was estimated by nonparametric stochastic deconvolution. Glucose uptake-specific indexes (S[Formula: see text] * × 10 2 : 0.81 ± 0.08 vs. 0.60 0.05 dl · min −1 kg , P <...
Bone adaptation to exercise relies on exposures impact loading in sports, but the ability of skeletal change seems be highly variable among individuals. The present study was designed investigate association between a poly‐morphism vitamin D receptor (VDR) gene at translation initiation site and bone mineral density (BMD). Analysis VDR genotypes detected by endonuclease FokI (FF, Ff, ff) measurement total body BMD (TBMD) were performed 212 young males; 84 athletes involved weight‐bearing 48...
To understand the role of IGF-I in murine pregnancy, we studied reproductive performance overexpressed mice. Fetal loss occurred only transfected uterine horn during Day 10-15 pregnancy. The placenta appeared healthy until 10 From 12, decidua basalis increased thickness. vascular lumen was expanded, and most embryos were dead. Uterine Natural Killer cells did not undergo apoptosis from to 15 when they usually go through apoptosis. Thus, it is likely that plays a decidual formation regulation...
Relationships between female reproductive performance and uterine natural killer (uNK) cells were investigated in pregnant IL-2 receptor β-chain overexpressed transgenic (Tg2R β) mice. At 8 days of pregnancy, all fetuses alive, suggesting that implantation normally occurred these However, 47% dead at 10 pregnancy 12 resorbing, indicating fetal loss progressed with the advance pregnancy. The placenta Tg2Rβ mice gradually decreased weight placental labyrinth, decidua basalis, metrial gland...
This study aimed to investigate whether serum leucine-rich α2-glycoprotein (LRG) is a useful diagnostic biomarker for endometriosis, including the evaluation of treatment efficacy and exploration LRG production in endometriotic lesions.Forty-three women with endometriomas were compared 22 benign ovarian cysts 30 who underwent assisted reproduction as controls. Changes levels assessed before after surgery, during dienogest treatment. expression tissue samples was evaluated using...
To investigate whether progesterone plays an essential role in differentiation of uNK cells, we ectopically transplanted tissue grafts from different developmental stages uteri under various conditions. When female mice were used as recipients, decidualization and cells observed mature (8 weeks old) immature (4 donors, but there was no change postnatal (10 days after birth) donors. cell both not the recipient uterus even presence progesterone. These results suggest that is associated with...