A5031211738- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Heart Rate Variability and Autonomic Control
- EEG and Brain-Computer Interfaces
- Cardiac Ischemia and Reperfusion
- Inflammation biomarkers and pathways
- ECG Monitoring and Analysis
- Vagus Nerve Stimulation Research
- Calcium signaling and nucleotide metabolism
- Cardiac Arrhythmias and Treatments
- Neuroscience and Neuropharmacology Research
- Cardiovascular and exercise physiology
- MicroRNA in disease regulation
- Receptor Mechanisms and Signaling
- Cellular transport and secretion
- Non-Invasive Vital Sign Monitoring
- Inflammasome and immune disorders
- Piperaceae Chemical and Biological Studies
- S100 Proteins and Annexins
- Cardiac pacing and defibrillation studies
Ludwig-Maximilians-Universität München
2020-2024
Center for Integrated Protein Science Munich
2020-2021
Centre for Human Genetics
2018
University of Oxford
2018
Abstract It is highly debated how cyclic adenosine monophosphate-dependent regulation (CDR) of the major pacemaker channel HCN4 in sinoatrial node (SAN) involved heart rate by autonomic nervous system. We addressed this question using a knockin mouse line expressing monophosphate-insensitive channels. This displayed complex cardiac phenotype characterized sinus dysrhythmia, severe bradycardia, pauses and chronotropic incompetence. Furthermore, absence CDR leads to inappropriately enhanced...
S100A8/S100A9 is a proinflammatory mediator released by myeloid cells during many acute and chronic inflammatory disorders. However, the precise mechanism of its release from cytosolic compartment neutrophils unclear. Here, we show that E-selectin-induced rapid inflammation occurs in an NLRP3 inflammasome-dependent fashion. Mechanistically, E-selectin engagement triggers Bruton's tyrosine kinase-dependent phosphorylation NLRP3. Concomitant potassium efflux via voltage-gated channel KV1.3...
Loss or dysregulation of the normally precise control heart rate via autonomic nervous system plays a critical role during development and progression cardiovascular disease-including ischemic disease, failure, arrhythmias. While clinical significance regulating changes in rate, known as chronotropic effect, is undeniable, mechanisms controlling these remain not fully understood. Heart acceleration deceleration are mediated by increasing decreasing spontaneous firing pacemaker cells...
Abstract Abnormalities of ventricular action potential cause malignant cardiac arrhythmias and sudden death. Here, we aim to identify microRNAs that regulate the human ask whether their manipulation allows for therapeutic modulation abnormalities. Quantitative analysis microRNA targetomes in myocytes identifies miR-365 as a primary repolarizing ion channels. Action recordings patient-specific induced pluripotent stem cell-derived show elevation significantly prolongs duration derived from...
Key points β‐Cell K ATP channels are partially open in the absence of metabolic substrates, whereas cardiac closed. Using cloned heterologously expressed Xenopus oocytes we measured effect MgADP on MgATP concentration–inhibition curve immediately after patch excision. caused a far more striking reduction inhibition Kir6.2/SUR1 than Kir6.2/SUR2A channels; this declined rapidly Exchanging final 42 amino acids SUR was sufficient to switch Mg‐nucleotide regulation and channels, their sensitivity...
Blood pressure (BP) and heart rate (HR) are both controlled by the autonomic nervous system (ANS) closely intertwined due to reflex mechanisms. The baroreflex is a key homeostatic mechanism counteract acute, short-term changes in arterial BP maintain relatively narrow physiological range. sensed baroreceptors located aortic arch carotid sinus. When changes, signals transmitted central then communicated parasympathetic sympathetic branches of adjust HR. A rise causes decrease HR, drop...
Blood pressure (BP) and heart rate (HR) are both controlled by the autonomic nervous system (ANS) closely intertwined due to reflex mechanisms. The baroreflex is a key homeostatic mechanism counteract acute, short-term changes in arterial BP maintain relatively narrow physiological range. sensed baroreceptors located aortic arch carotid sinus. When changes, signals transmitted central then communicated parasympathetic sympathetic branches of adjust HR. A rise causes decrease HR, drop...