A5023254901- Erythrocyte Function and Pathophysiology
- Ion Channels and Receptors
- Inflammation biomarkers and pathways
- S100 Proteins and Annexins
- Inflammasome and immune disorders
- Ion channel regulation and function
Ludwig-Maximilians-Universität München
2021-2023
S100A8/S100A9 is a proinflammatory mediator released by myeloid cells during many acute and chronic inflammatory disorders. However, the precise mechanism of its release from cytosolic compartment neutrophils unclear. Here, we show that E-selectin-induced rapid inflammation occurs in an NLRP3 inflammasome-dependent fashion. Mechanistically, E-selectin engagement triggers Bruton's tyrosine kinase-dependent phosphorylation NLRP3. Concomitant potassium efflux via voltage-gated channel KV1.3...
Abstract Aims Neutrophil trafficking within the vasculature strongly relies on intracellular calcium signalling. Sustained Ca2+ influx into cell requires a compensatory efflux of potassium to maintain membrane potential. Here, we aimed investigate whether voltage-gated channel KV1.3 regulates neutrophil function during acute inflammatory process by affecting sustained Methods and results Using in vitro assays electrophysiological techniques, show that is functionally expressed human...