A5038466624- RNA Research and Splicing
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- CRISPR and Genetic Engineering
- Neurobiology and Insect Physiology Research
- Developmental Biology and Gene Regulation
- Hippo pathway signaling and YAP/TAZ
- Cellular Mechanics and Interactions
- Invertebrate Immune Response Mechanisms
- Gene Regulatory Network Analysis
- RNA and protein synthesis mechanisms
- RNA regulation and disease
- Genomics and Chromatin Dynamics
- Advanced biosensing and bioanalysis techniques
- Ubiquitin and proteasome pathways
- Cell Image Analysis Techniques
- Chromosomal and Genetic Variations
- Animal Genetics and Reproduction
- Wnt/β-catenin signaling in development and cancer
- Morphological variations and asymmetry
- Single-cell and spatial transcriptomics
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
- Plant Virus Research Studies
- RNA modifications and cancer
Northwestern University
2015-2024
Quantitative BioSciences
2020-2024
University of Michigan
2021
Indo-American Center
2016
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
2016
Evanston Hospital
2014
University of Chicago
2013
Center for Systems Biology
2012-2013
Bethesda University
2007
University of California, Riverside
2006
Innate immunity against bacterial and fungal pathogens is mediated by Toll immune deficiency (Imd) pathways, but little known about the antiviral response in Drosophila . Here, we demonstrate that an RNA interference pathway protects adult flies from infection two evolutionarily diverse viruses. Our work also describes a molecular framework for viral immunity, which double-stranded produced during acts as pathogen trigger whereas Dicer-2 Argonaute-2 act host sensor effector, respectively....
A simple approach has been developed for the unambiguous identification and purification of sequence-specific DNA-binding proteins solely on basis their ability to bind selectively target sequences. Four independent methods were used identify promoter-specific RNA polymerase II transcription factor MLTF as a 46-kilodalton (kDa) polypeptide. First, 46-kDa protein was specifically cross-linked by UV irradiation body-labeled DNA fragment containing binding site. Second, sedimented through...
RNA silencing (RNAi) induced by virus-derived double-stranded (dsRNA), which is in a sense regarded as pathogen-associated molecular pattern (PAMP) of viruses, general plant defense mechanism. To counteract this defense, viruses express suppressors (RSSs), many bind to dsRNA and attenuate RNAi. We showed that the tobacco calmodulin-like protein, rgs-CaM, counterattacked viral RSSs binding their dsRNA-binding domains sequestering them from inhibiting Autophagy-like protein degradation seemed...
Coordinated morphogenesis of ommatidia during Drosophila eye development establishes a mirror-image symmetric pattern across the entire bisected by an anteroposterior equator. We have investigated mechanisms which this formation occurs and our results suggest that is coordinated graded signal transmitted bidirectionally from presumptive equator to dorsal ventral poles. This mediated frizzled, encodes cell surface transmembrane protein. Mosaic analysis indicates frizzled acts non-autonomously...
Repression of gene transcription is a fundamental property nuclear hormone receptors. We report here that cell-specific repression by receptors correlates with levels receptor corepressor (N-CoR) protein. N-CoR protein are regulated mSiah2, mammalian homolog Drosophila Seven in absentia targets for proteasomal degradation. mSiah2 expression cell-type specific and differentially regulates the repressive activities These findings establish targeted proteolysis transcriptional coregulators as...