A5018001372- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Adipokines, Inflammation, and Metabolic Diseases
- Sirtuins and Resveratrol in Medicine
- Circular RNAs in diseases
- Atherosclerosis and Cardiovascular Diseases
- Adipose Tissue and Metabolism
- Advanced Glycation End Products research
- Fatty Acid Research and Health
- Inflammasome and immune disorders
China Medical University
2017-2024
Obesity has been associated with osteoarthritis (OA) due to increased mass and metabolic factors which are independent of the biomechanical contribution joint load. Resveratrol, a natural polyphenolic compound, exerts protective effects on OA through its anti-inflammatory property. However, mechanism resveratrol obesity-related is unclear. To investigate effect possible oral OA, we fed C57BL/6J mice high-fat diet (HFD) for 16 weeks establish model; then two doses (22.5 mg/kg 45 mg/kg) were...
Aim of the study: Obesity leads to mild, chronic inflammation which is a primary risk factor for osteoarthritis (OA). Resveratrol exerts protective effect on OA through its anti-inflammatory properties, but precise mechanism remains unknown. The present study aimed investigate by resveratrol alleviates obesity-related OA, and whether it linked TLR4 PI3K/Akt signaling pathways.Materials methods: C57BL/6J male mice were fed high-fat diet (HFD) with or without treatment knee joints collected...
Obesity is considered as a risk factor of osteoarthritis (OA), but the precise relationship still poorly understood. Leptin, one most relevant factors secreted by adipose tissues, plays an important role in pathogenesis OA. Our aim was to investigate regulation and molecular mechanism leptin signaling pathway obesity‐related SD rats were fed with high‐fat diet (HFD) for 5, 15, 27 weeks. The levels serum increased from W5, while synovial fluid W15. histological evaluation showed that...
Osteoarthritis (OA) is associated with chronic low-grade inflammation. Resveratrol exerts protective effects on OA through its anti-inflammatory property; however, the mechanism of resveratrol signaling pathways has not been fully elucidated yet. The aim present study was to investigate whether resveratrol-mediated PI3K/Akt expression linked TLR4/NF-κB pathway and role TLR4/Akt/FoxO1 axis in anti-osteoarthritic effect resveratrol.SW1353 cells stimulated by IL-1β (10 ng/mL) were cultured...