A5000919841- Cancer, Lipids, and Metabolism
- Blood groups and transfusion
- Platelet Disorders and Treatments
- Adrenal Hormones and Disorders
- Renal Diseases and Glomerulopathies
- Erythrocyte Function and Pathophysiology
- Lipoproteins and Cardiovascular Health
- Neonatal Health and Biochemistry
- Inflammatory Bowel Disease
- Blood disorders and treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Thyroid Disorders and Treatments
- Hormonal Regulation and Hypertension
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Neutropenia and Cancer Infections
- Chromosomal and Genetic Variations
- Chronic Lymphocytic Leukemia Research
- Melanoma and MAPK Pathways
- Air Quality and Health Impacts
- PI3K/AKT/mTOR signaling in cancer
- Genomic variations and chromosomal abnormalities
- Diet, Metabolism, and Disease
- Chemotherapy-related skin toxicity
Policy Analysis (United States)
2018-2019
Rush University Medical Center
1996-1997
Presbyterian St. Luke's Medical Center
1996-1997
Northwestern University
1960-1996
St Bartholomew's Hospital
1992
Homerton University Hospital
1992
Rebecca Sieff Hospital
1989
Rosalind Franklin University of Medicine and Science
1968-1970
Mount Sinai Hospital
1966-1969
Sinai Hospital
1966-1968
Chemotherapy-induced thrombocytopenia (CIT) is a potentially serious complication that can lead to chemotherapy dose delays, reductions, or discontinuation, and increases the risk of bleeding events. The objectives this study were characterize incidence, clinical consequences, economic costs CIT in current US practice.A retrospective cohort design data from two private healthcare claims repositories (01/2010-12/2016) employed. Study population comprised adults who received selected...
Abstract Taxol may contribute to intrinsic chemoresistance by activating the mitogen-activated protein kinase (MEK)/extracellular signal-regulated (ERK) cytoprotective pathway in human cancer cell lines and tumors. We have previously shown additivity between MEK inhibitor, U0126 lines. Here, combination of with an orally bioavailable CI-1040, was evaluated lung tumors heterotransplanted into nude mice. Unlike xenograft models that are derived from cells multiple genetic alterations due...
Introduction: Primary immune thrombocytopenia (ITP), an autoimmune disorder characterized by low platelet count, can lead to serious bleeding events. Little is known about the current epidemiology of ITP in US, and even less healthcare burden ITP, especially 12-month period following diagnosis.Method: We used a retrospective cohort design data from two US private claims databases (2010-2016) identify persons with evidence newly diagnosed ITP. weighted estimates annual incidence age sex...
IN A PRECEDING paper<sup>1</sup>electrolyte balance studies were carried out on premature infants who a diet of diluted evaporated milk and "dextri-maltose." The results demonstrated that these tended to retain small quantities chloride in excess the sodium required for formation new extracellular fluid normal composition. Consequently, serum concentration was somewhat higher than adults or full term, breast-fed infants, carbon dioxide content slightly lower. levels be low side normal....
In 99 patients with sickle cell anemia and 100 normal Negro children, the activity of glucose-6-phosphate dehydrogenase in erythrocytes was determined. Hemoglobinopathies may be combined reduced erythrocytes. The two defects are inherited independently. incidence enzymatic defect those this series does not differ from that a similar population having hemoglobin. There appears to no significant effect on clinical course or survival times their Patients stability glutathione have significantly...
A case of apathetic hyperthyroidism with thyroid storm occurring in a 10-year-old girl is reported. Satisfactory response to treatment propylthiouracil, cortisone and penicillin was obtained. Neglected children, as adults, may lead the serious complications storm.
Plasma lipoprotein lipase activity was determined in six children with idiopathic nephrotic syndrome and controls. The mean significantly lower the symptomatic patients. This decreased enzyme may contribute to hyperlipemia usually observed syndrome. See table PDF file
Eight cases of chronic hepatitis with marked hypergammaglobulinemia occurring in pediatric patients are reported. Arthralgia, abdominal pain, skin rashes, and bleeding tendencies were present these patients, but none had a positive lupus cell preparation. Administration adrenocortical steroid drugs was followed by clinical improvement four no significant change one. Despite the administration drugs, three died. At autopsy, postnecrotic cirrhosis found each cases. The etiology syndrome has...
This paper describes a Negro family with congenital nonspherocytic hemolytic anemia associated glucose-6-phosphate dehydrogenase deficiency. All four affected males in this showed characterized by low hemoglobin, reticulocytosis, and jaundice. There was no detectable G-6-P D the red cells about tenth of normal enzyme activity white cells. By starch gel electrophoresis, present as single band which migrated at rate 104% normal. Physico-chemical studies revealed marked increase Michaelis...
The ECHELON-1 trial demonstrated efficacy and safety of brentuximab vedotin plus doxorubicin, vinblastine, dacarbazine (A + AVD) vs bleomycin, (ABVD) as frontline therapy for stage III/IV classical Hodgkin lymphoma. This analysis evaluated the cost-effectiveness A AVD from a US healthcare payer perspective.The incremental ratio (ICER), defined costs per quality-adjusted life year (QALY) gained, was estimated using non-homogenous semi-Markov cohort model with health states on progression...
Balanced D/D translocation carriers appear to be normal in most instances (Court-Brown et al., 1966; Giannelli and Howlett, 1966). In some cases, however, a variety ofcongenital malformations has been reported, such as Klinefelter's syndrome (Lejeune, Turpin, Decourt, 1960), little secondary sex development (Walker Harris, 1962), malformation of the spine (de Grouchy 1963), arrested hydrocephalus accompanied by mental retardation spastic diplegia (Jagiello, hydrocele azoospermia (Yunis...
Ten members of two families with D/G translocation, three a family D/D and one patient non‐familial apparently translocation were examined. The trdnslocation chromosomes identified by SH‐thymidine labeling autoradio‐graphy as 14q21q 13q14q, respectively. These findings support the hypothesis nonrandomness D group involved in centric‐fusion translocation. importance identification Dgroup centriofusion relation to genetic counseling is discussed.