A5101912114- Platelet Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Transplantation: Methods and Outcomes
- Sarcoma Diagnosis and Treatment
- Blood groups and transfusion
- Appendicitis Diagnosis and Management
- Organ Transplantation Techniques and Outcomes
- Ear and Head Tumors
- Poisoning and overdose treatments
- Renal Transplantation Outcomes and Treatments
- Oral and Maxillofacial Pathology
- Cutaneous Melanoma Detection and Management
- Intestinal and Peritoneal Adhesions
- Neuroendocrine Tumor Research Advances
- Intraperitoneal and Appendiceal Malignancies
- Cervical Cancer and HPV Research
- Cytomegalovirus and herpesvirus research
- Pancreatitis Pathology and Treatment
- Mechanical Circulatory Support Devices
- Thyroid Cancer Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Ovarian cancer diagnosis and treatment
- CAR-T cell therapy research
- Autoimmune Bullous Skin Diseases
- Pancreatic and Hepatic Oncology Research
Bhagwan Mahaveer Cancer Hospital and Research Centre
2004-2024
Panjab University
2024
Vardhman Mahavir Medical College & Safdarjung Hospital
2024
MVN University
2024
Lady Hardinge Medical College
2024
Keck Hospital of USC
2017-2022
Columbia University Irving Medical Center
2021
New York Hospital Queens
2021
NewYork–Presbyterian Hospital
2021
Columbia University
2021
Cervical cancer is the main among women in sub-Saharan Africa, India and other parts of developing world. Evaluation screening performance effective, feasible affordable early detection management methods a public health priority. Five methods, naked eye visual inspection cervix uteri after application diluted acetic acid (VIA), or Lugol's iodine (VILI) with magnifying device (VIAM), Pap smear human papillomavirus testing high-risk probe Hybrid Capture-2 assay (HC2), were evaluated 11...
Chemotherapy-induced thrombocytopenia (CIT) is a potentially serious complication that can lead to chemotherapy dose delays, reductions, or discontinuation, and increases the risk of bleeding events. The objectives this study were characterize incidence, clinical consequences, economic costs CIT in current US practice.A retrospective cohort design data from two private healthcare claims repositories (01/2010-12/2016) employed. Study population comprised adults who received selected...
Airway hyperresponsiveness is easily assessed by measuring the concentration or dose of an inhaled agonist that produces a defined response, e.g., PC20 PD20. However, this measure does not assess excessive bronchoconstriction. We report results analyzing bronchial dose-response curves percent fall in vital capacity (delta FVC%) as response rather than PC20. In our analysis, delta FVC% was measured at PC20, and therefore it dependent variable, whereas independent contrast to usual...
Introduction: Primary immune thrombocytopenia (ITP), an autoimmune disorder characterized by low platelet count, can lead to serious bleeding events. Little is known about the current epidemiology of ITP in US, and even less healthcare burden ITP, especially 12-month period following diagnosis.Method: We used a retrospective cohort design data from two US private claims databases (2010-2016) identify persons with evidence newly diagnosed ITP. weighted estimates annual incidence age sex...
Objective: We conducted a multi-centre cross-sectional study in India to evaluate the accuracy of conventional cytology detect high-grade squamous intraepithelial lesions (HSIL). Setting: Cross-sectional studies Jaipur, Kolkata, Mumbai and Trivandrum, India, during 1999-2003. Methods: A common protocol questionnaire were used test 22,663 women aged 25-65 years with five studies. Three thresholds define positivity: atypical cells uncertain significance (ASCUS), low-grade intra-epithelial...
Talimogene laherparepvec (T-VEC) has demonstrated efficacy for unresectable melanoma. We explored response patterns from a phase 2 study evaluating patients with stage IIIB–IVM1c malignant melanoma who received T-VEC plus ipilimumab or alone. Patients objective per modified irRC were evaluated pseudo-progression (single ≥25% increase in tumour burden before response). without classified by whether they responded within after 6 months of treatment start; those was due to existing lesions...
9520 Background: We previously reported that neo T-VEC + surgx resulted in a pathologic CR rate of 21% and an OR 14.7% randomized trial vs upfront pts with resectable stage IIIB/C/IVM1a MEL (Andtbacka et al, ASCO 2018; NCT02211131). Here, we present results from interim 1-yr analysis RFS. Methods: Patients (pts) MEL, ≥ 1 injectable cutaneous, subcutaneous, or nodal lesions 10 mm, no systemic tx 3 mos prior were 1:1 to 6 doses/12 wks followed by during 13-18 (Arm 1) 1-6 2). was given at...
Myotonic dystrophy often presents with cardiac abnormalities, particularly conduction defects, that factor into an increased risk of sudden death. has two forms, myotonic type 1 (DM1) and DM2, is a multisystemic disorder in wide, clinical spectrum age range. A distinguishing feature DM1 the existence congenital form. Though research on involvement been conducted patients adult form dystrophy, there have few studies focused pediatric (CDM1). In this study, survey was to determine prevalence...
Several studies have reported association of c.101A>G (p.N34S) mutation in SPINK1 gene with chronic pancreatitis; however, the data on its relationship acute pancreatitis (AP) and recurrent (RAP) are limited.We studied 183 unrelated patients AP RAP 168 healthy controls for p.N34S variant using sequencing genomic DNA.SPINK1 was found four (2.4%; all heterozygotes) 22 (12.0%; including one homozygote) (P = 0.006). On subgroup analysis, seven 70 (10.0%) gallstone-related AP, eight 59 (13.6%;...
Thyroid lesions are fairly common & have a wide spectrum of diseases ranging from functional, immune mediated to neoplastic lesions. All thyroidectomy specimens were included in the study period 1.5 years September 2019 February 2021 at our institute, total 10,200 biopsies sent department for histopathological examination, out which 7200 diagnosed as malignant cases, 408 (5.6%) cases thyroid cancer (TC) cases. One hundred forty-five (35.53%) TC underwent surgeries, fifty consecutive who...
Background: Diagnosis of thyroid carcinoma is not always straight forward on haematoxylin and eosin staining since nuclear features are inconsistent, overlapping controversial. In regards to this, many studies the role immunohistochemical markers for diagnosis malignant needed. order improve diagnostic accuracy, immunohistochemistry techniques have mainly emphasized galectin-3 (Gal-3) Hector Battifora Mesothelial-1 (HBME-1). However, results remain unsatisfactory. The aim present article was...
Purpose: Patients with immune thrombocytopenia (ITP) have low platelet counts and an increased risk of bleeding. We described treatment patterns clinical outcomes in routine practice the United States (US). Methods: Using electronic health record data from hematology/oncology clinics linked to administrative claims US, we studied 447 adults newly diagnosed primary ITP 2011 2016. a secondary cause were excluded. The incidence initiation, bleeding events, rescue therapy use estimated using...
Progressive familial intrahepatic cholestasis (PFIC) is caused by variations in ATP8B1, ABCB11 or ABCB4 genes. Data on genetic Indian patients with PFIC are lacking. Coding and splice regions of the three genes were sequenced unrelated children phenotype. The identified looked for parents, 30 healthy persons several variation databases, their effect was assessed in-silico. Among 25 (aged 1–144 months), nine (36%) had unique major genomic (ATP8B1: 4, ABCB11: 3 ABCB4: 2). Seven homozygous...