A5083775669- Renal and Vascular Pathologies
- Dialysis and Renal Disease Management
- Cardiovascular Disease and Adiposity
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Kidney Stones and Urolithiasis Treatments
- Cytomegalovirus and herpesvirus research
- Palliative Care and End-of-Life Issues
- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- Pediatric Urology and Nephrology Studies
- Obesity and Health Practices
- Neurological Complications and Syndromes
- Aortic aneurysm repair treatments
- Thyroid Cancer Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Electrolyte and hormonal disorders
- Adipose Tissue and Metabolism
- Mesenchymal stem cell research
- Esophageal and GI Pathology
- Bipolar Disorder and Treatment
- Organ Transplantation Techniques and Outcomes
- Patient-Provider Communication in Healthcare
- Autoimmune Bullous Skin Diseases
- Healthcare Policy and Management
Beth Israel Deaconess Medical Center
2021-2025
Harvard University
2022-2025
Pravara Institute of Medical Sciences
2024
Mayo Clinic
2013-2023
Mayo Clinic in Arizona
2018-2023
Cooper Hospital
2020
WinnMed
2019
Mercy Catholic Medical Center
2015-2017
Sun Yat-sen University
2014-2015
The First Affiliated Hospital, Sun Yat-sen University
2014-2015
Kidney biopsy is the gold standard to diagnose membranous nephropathy (MN). Approximately 70%-80% of patients with primary MN have anti-phospholipase A2 receptor (PLA2R) antibodies. We hypothesized that PLA2R antibody testing without kidney may be a valid strategy make non-invasive diagnosis in negative work-up for secondary causes. The medical records all Mayo Clinic Minnesota, Florida, and Arizona serum tests between January 2015 June 2018 were reviewed. was performed 838 unique patients,...
Objective To establish and characterize a novel domestic porcine model of obesity. Methods Fourteen pigs were fed normal (lean, n = 7) or high-fat/high-fructose diet (obese, for 16 weeks. Subcutaneous abdominal adipose tissue biopsies obtained after 8, 12, weeks diet, pericardial weeks, assessments adipocyte size, fibrosis, inflammation. Adipose volume cardiac function studied with multidetector computed tomography, oxygenation was magnetic resonance imaging. Plasma lipids profile, insulin...
Renovascular hypertension alters cardiac structure and function. Autophagy is activated during left ventricular hypertrophy linked to adverse The angiotensin II receptor blocker, valsartan, lowers blood pressure cardioprotective, but whether it modulates autophagy in the myocardium unclear. We hypothesized that valsartan would alleviate improve myocardial mitochondrial turnover swine renovascular hypertension. Domestic pigs were randomized control, unilateral hypertension, treated with (320...
Obesity-metabolic disorders (ObM) often accompany renal artery stenosis (RAS). We hypothesized that the coexistence of ObM and RAS magnifies inflammation microvascular remodeling in stenotic kidney (STK) aggravates scarring. Twenty-eight obesity-prone Ossabaw pigs were studied after 16 wk a high-fat/high-fructose diet or standard chow including ObM-sham, ObM-RAS, Lean-RAS, Lean-sham (normal control) groups. Single-kidney blood flow (RBF) glomerular filtration rate (GFR) assessed by...
<sec> <title>BACKGROUND</title> Choosing a transplant program impacts patient’s likelihood of receiving kidney transplant. Most patients are unaware the factors influencing their candidacy. As increasingly rely on online resources for healthcare decisions, this study quantifies available patient-level information recipient (KTR) selection criteria across U.S. centers. </sec> <title>OBJECTIVE</title> Quantify <title>METHODS</title> A cross-sectional using natural language processing and large...
Obesity and hypertension are major risk factors for cardiovascular diseases, their growing coexistence accounts an increase in adverse cardiac events, but the mechanisms yet to be determined. We hypothesized that obesity exacerbates mitochondrial dysregulation imposed by augments left ventricular dysfunction. Obesity-prone Ossabaw pigs were randomized lean (standard diet) obese (high-fat diet), without (Lean-sham Obese-sham) or with renovascular (Lean-hypertension Obese-hypertension),...
Obesity promotes dysfunction and impairs the reparative capacity of mesenchymal stem/stromal cells (MSCs), alters their transcription, protein content, paracrine function. Whether these adverse effects are mediated by chromatin-modifying epigenetic changes remains unclear. We tested hypothesis that obesity imposes global DNA hydroxymethylation histone tri-methylation alterations in obese swine abdominal adipose tissue-derived MSCs compared to lean pig MSCs. from female (n = 7) high-fat-diet...
Mesenchymal stem cells (MSCs) possess endogenous reparative properties and may serve as an exogenous therapeutic intervention in patients with chronic kidney disease. Cardiovascular risk factors clustering the metabolic syndrome (MetS) might adversely affect cellular properties. To test hypothesis that Mets interferes MSC characteristics, we performed comprehensive comparison of mRNA, microRNA, protein content MSCs isolated from Lean MetS pigs. Domestic pigs were fed a 16-week or diet (n = 4...
Renal artery stenosis (RAS) is an important cause of chronic kidney disease and secondary hypertension. In animal models, renal ischemia leads to downregulation growth factor expression loss intrarenal microcirculation. However, little known about the sequelae large-vessel occlusive on microcirculation within human kidneys.This study included five patients who underwent nephrectomy due renovascular occlusion seven nonstenotic discarded donor kidneys (four deceased donors). Micro-computed...
Background Obesity is a major public health challenge, and recent literature sheds light on the concept of “normalization” obesity. Objective We aimed to study worldwide pattern web-based information seeking by obesity its related terms topics using Google Trends. Methods compared relative frequency obesity-related search between 2004 2019 The mean interest scores for these over 4-year quartiles were compared. Results score term “obesity” consistently decreased with time in all four...
Background: Diagnosis of thyroid carcinoma is not always straight forward on haematoxylin and eosin staining since nuclear features are inconsistent, overlapping controversial. In regards to this, many studies the role immunohistochemical markers for diagnosis malignant needed. order improve diagnostic accuracy, immunohistochemistry techniques have mainly emphasized galectin-3 (Gal-3) Hector Battifora Mesothelial-1 (HBME-1). However, results remain unsatisfactory. The aim present article was...
Renal artery stenosis (RAS) is a major cause of ischemic kidney disease, which largely mediated by inflammation. Mapping the immune cell composition in kidneys might provide useful insight into disease pathogenesis and uncover therapeutic targets. We used mass cytometry (CyTOF) to explore single-cell unique data set human nephrectomized due chronic occlusive vascular (RAS,
Dialysis comes with a substantial treatment burden, so patients must select care plans that align their preferences. We aimed to deepen the understanding of decisional regret dialysis choices.
Background Approximately 750,000 people in the U.S. live with end-stage kidney disease (ESKD); majority receive dialysis. Despite importance of adherence to dialysis, it remains suboptimal, and one contributor may be patients’ insufficient capacity cope their treatment illness burden. However, is unclear what, if any, differences exist between patients reporting high versus low Methods We sought understand these using a mixed methods, explanatory sequential design. enrolled adult receiving...
A 59-year-old man with a history of bipolar disorder was admitted to the hospital after fall and incidentally found have numerous small renal cysts, finding consistent previous lithium treatment.
Sir, Horseshoe kidney is the most common congenital renal fusion anomaly, with an incidence of 1 every 400–1600 births.[12] Kidney stones are in patients horseshoe a reported ranging approximately from 20% to 80%.[13] Although altered anatomy-related impaired urinary drainage proposed explanation for stone formation kidney,[13] its exact underlying mechanism still unclear. Hereby, we present 34-year-old male recurrent stones. The patient was found have and suggestive findings probable...
Esophagectomy is the mainstay treatment for cancer of esophagus. Over last two decades robotic assisted minimally invasive oesephagectomy (RAMIE) have become increasingly popular in esophageal surgery. We present a rare complication an air leak following RAMIE. Our patient underwent total mobilization, lymph node dissection transthoracically lower oesophageal tumour. He developed persistent and needed oxygen support. Following which thoracoscopic bullectomy was done, lung successfully...
Background: Number of prognostic factors for thyroid carcinoma have been identified including age, gender and tumor characteristics, such as histology stage. The importance these independent predictors survival patients with differentiated has extensively studied but remains uncertain. Methods: A retrospective analysis 50 carcinomas was made to assess histological variants from September 2019 February 2022 at our centre. surgical histopathological data were studied. Results: 72% had...
Testicle tumors are a rare entity among men population, comprising 1-1.5% of all cancers. The Sex cord Stromal contribute just 4% testicular cancers, only 10% them malignant. Most common sex cord-stromal the Leydig cell tumor, 75 to 80% total. Incidence is bimodal involving children and adults between 30 60 years. commonest metastatic sites regional lymph nodes, lung, liver, bones. Here, we report case late relapsed tumor in 38-year-old male. Patients with have poor prognosis standard...