A5091120783- Tissue Engineering and Regenerative Medicine
- Cardiovascular Function and Risk Factors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Childhood Cancer Survivors' Quality of Life
- Cardiovascular Disease and Adiposity
- Nitric Oxide and Endothelin Effects
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Eicosanoids and Hypertension Pharmacology
Mayo Clinic
2020-2022
Alfaisal University
2015
Obesity promotes dysfunction and impairs the reparative capacity of mesenchymal stem/stromal cells (MSCs), alters their transcription, protein content, paracrine function. Whether these adverse effects are mediated by chromatin-modifying epigenetic changes remains unclear. We tested hypothesis that obesity imposes global DNA hydroxymethylation histone tri-methylation alterations in obese swine abdominal adipose tissue-derived MSCs compared to lean pig MSCs. from female (n = 7) high-fat-diet...
Objective Elevated Reactive Oxygen Species (ROS) in Endothelial Cells (EC's) have been implicated the pathogenesis of cardiovascular diseases, and much research has gone into elucidating mechanisms through which oxidative stress leads to these diseases. Research last decade, however, uncovered central role lower levels ROS play physiological intracellular signaling pathways, such as those stimulated by Vascular Growth Factor (VEGF) Tumour Necrosis Factor‐α (TNF‐α) EC's. Our objective this...