A5000425356- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- interferon and immune responses
- Inflammation biomarkers and pathways
- Immune Cell Function and Interaction
- RNA regulation and disease
- Autoimmune Bullous Skin Diseases
- Immunotherapy and Immune Responses
- Drug-Induced Adverse Reactions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Asthma and respiratory diseases
- Urticaria and Related Conditions
- Neonatal Respiratory Health Research
- T-cell and B-cell Immunology
- Sarcoidosis and Beryllium Toxicity Research
- RNA modifications and cancer
- Immunodeficiency and Autoimmune Disorders
- Immune cells in cancer
Humboldt-Universität zu Berlin
2018-2024
Charité - Universitätsmedizin Berlin
2018-2024
Freie Universität Berlin
2018-2022
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2021
Orthopädische Universitätsklinik
2018
The systemic immune response to viral infection is shaped by master transcription factors, such as NF-κB, STAT1, or PU.1. Although long noncoding RNAs (lncRNAs) have been suggested important regulators of factor activity, their contributions the immunopathologies observed during SARS-CoV-2 remained unknown. Here, we employed a targeted single-cell RNA sequencing approach reveal lncRNAs differentially expressed in blood leukocytes severe COVID-19. Our results uncover lncRNA PIRAT...
RNA has been proposed as an important scaffolding factor in the nucleus, aiding protein complex assembly dense intracellular milieu. Architectural contributions of to cytosolic signaling pathways, however, remain largely unknown. Here, we devised a multidimensional gradient approach, which systematically locates components within cellular networks. Among subset noncoding RNAs (ncRNAs) cosedimenting with ubiquitin-proteasome system, our approach unveiled ncRNA MaIL1 critical structural...
Rationale: Pulmonary sarcoidosis is generally presumed to be a T-helper cell type 1- and macrophage-driven disease. However, mouse models have recently revealed that chronically inflamed lung tissue can also comprise T follicular helper (Tfh)-like cells represents site of active T-cell/B-cell cooperation. Objectives: To assess the role pulmonary Tfh- germinal center-like lymphocytes in sarcoidosis. Methods: BAL fluid, tissue, peripheral blood samples from patients with were analyzed by flow...
Abstract Background Erythema multiforme (EM) is an acute, immune-mediated mucocutaneous disease, most often preceded by herpes simplex virus (HSV) infection or reactivation. Mycoplasma pneumoniae (Mp) considered the second major trigger of EM and associated with atypical more severe presentation characterized prominent mucosal involvement. However, contrary to HSV-associated (HAEM), immunological mechanisms Mp-associated remain unclear. Case We present case a 50-year-old male patient...
Rationale: Acute lung injury is frequently caused by pneumonia, and severity correlates with inflammatory cell recruitment barrier failure. Deciphering drug-targetable pathways of clinical importance. Objectives: Investigation paracrine autocrine effects epithelial-derived chemokine CXCL5 in acute injury. Methods: We assessed the role related chemokines patients severe pneumonia primary cells or lines challenged Streptococcus pneumoniae exposed to mechanical stretch. Furthermore, we...
Abstract The systemic immune response to viral infection is shaped by master transcription factors such as NFκB or PU.1. Although long non-coding RNAs (lncRNAs) have been suggested important regulators of factor activity, their contributions the immunopathologies observed during SARS-CoV-2 remained unknown. Here, we employed a targeted single-cell RNA-seq approach reveal lncRNAs differentially expressed in blood leukocytes severe COVID-19. Our results uncover lncRNA PIRAT major PU.1...