A5010448078- Neural dynamics and brain function
- Advanced Memory and Neural Computing
- HIV Research and Treatment
- Advanced Electron Microscopy Techniques and Applications
- Ferroelectric and Negative Capacitance Devices
- Cell Image Analysis Techniques
- IgG4-Related and Inflammatory Diseases
- Gastrointestinal disorders and treatments
- Cytomegalovirus and herpesvirus research
- Virtual Reality Applications and Impacts
- Viral gastroenteritis research and epidemiology
- Bartonella species infections research
- Visual and Cognitive Learning Processes
- Skin and Cellular Biology Research
- Computational Physics and Python Applications
- Neuroendocrine Tumor Research Advances
- Nail Diseases and Treatments
- Microbial infections and disease research
- Cutaneous lymphoproliferative disorders research
- Nephrotoxicity and Medicinal Plants
- Antimicrobial Resistance in Staphylococcus
- Connexins and lens biology
- Renal Diseases and Glomerulopathies
- Drug-Induced Hepatotoxicity and Protection
- Streptococcal Infections and Treatments
University of South Florida
2014-2023
James A. Haley Veterans' Hospital
2021-2023
Carleton University
2018-2021
Florida College
2016
University of Sussex
2005-2010
University of Florida Health
2010
ING Direct
2010
Center for Cancer Research
2007-2009
National Cancer Institute
2007-2008
National Institutes of Health
2007
The envelope glycoproteins of primate lentiviruses, including human and simian immunodeficiency viruses (HIV SIV), are heterodimers a transmembrane glycoprotein (usually gp41), surface (gp120), which binds CD4 on target cells to initiate viral entry. We have used electron tomography determine the three-dimensional architectures purified SIV virions in isolation contact with CD4+ cells. trimeric spikes heterogeneous appearance typically approximately 120 A long wide at distal end. Docking or...
HIV-1-containing internal compartments are readily detected in images of thin sections from infected cells using conventional transmission electron microscopy, but the origin, connectivity, and 3D distribution these has remained controversial. Here, we report viruses HIV-1-infected primary human macrophages cryo-electron tomography ion-abrasion scanning microscopy (IA-SEM), a recently developed approach for nanoscale imaging whole cells. Using IA-SEM, show presence an extensive network...
Identifying structural determinants of human immunodeficiency virus (HIV) neutralization is an important component rational drug and vaccine design. We used cryoelectron tomography atomic force microscopy to characterize the structure extremely potent HIV-neutralizing protein, D1D2-Ig alpha tp (abbreviated as D1D2-IgP), a polyvalent antibody construct that presents dodecameric CD4 in place Fab regions. show D1D2-IgP has novel structure, displaying greater flexibility its arms than closely...
Spatial awareness is crucial for human performance efficiency of any task that entails perception space. Memory spaces an imperfect reflection the cognitive activity (awareness states) underlies in such environments. Furthermore, on these tasks may also be influenced by context environment. This research investigates effect stereo viewing object recognition after exposure to immersive VE, terms both scene and associated states. The simulation consisted a radiosity-rendered room was either...
Spiking neural networks can exhibit complex firing regimes whose characteristics are influenced by network topology. This paper is part of an investigation into the dynamical properties spiking generated with small world topologies in comparison to those Erdos-Renyi random graphs. Specifically, parameters for and graph topology generation tested empirically find values which give rise stable (fixed or periodic) vs. unstable dissipative patterns. Similar topologies, a critical threshold was...
Ecthyma is an invasive form of impetigo that penetrates deep into the dermis. This cutaneous infection characterized by a crusted papule or plaque beneath which ulcer forms. Although typically associated with group A β-hemolytic streptococci, other pathogens have ability to produce ecthyma.1 Here we present case ecthyma from Moraxella and Staphylococcus epidermidis were isolated. has never been reported cause ecthyma, there 1 caused S epidermidis.
A 54 year-old female with a history of labile type II diabetes mellitus, chronic kidney disease, hypertension, anterior uveitis, angina, dyspnea and wheezing, abdominal pain, nausea, vomiting, diarrhea, constipation, weight loss presents an 8-month firm, warm, moderately tender subcutaneous nodules the right anterolateral thigh that enlarged concurrent rapid progression renal insufficiency.Prior imaging had demonstrated mesenteric, peripancreatic, retroperitoneal, mediastinal...
Advances in automated data acquisition electron tomography have led to an explosion the amount of that can be obtained about spatial architecture a variety biologically and medically relevant objects with sizes "nano" range 10-1000 nm. The development methods analyze vast amounts information contained these tomograms is major challenge since are intrinsically noisy. A fundamental step automatic analysis large for statistical inference segment 3D features cellular work robustly rapidly...
This research investigates the effect of stereo and 'real-world' scene context on object recognition within an immersive Virtual Environment (VE). 24 participants across two visual conditions varying depth cues (absence/presence stereo) including objects with varied association to context, were being exposed VE completed object-based memory task. Results revealed that performance was greater than cues.