A5100783315- Neuroscience and Neuropharmacology Research
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Urinary Bladder and Prostate Research
- Advanced Wireless Communication Techniques
- Asthma and respiratory diseases
- Healthcare Policy and Management
- Alzheimer's disease research and treatments
- Urological Disorders and Treatments
- Heart Failure Treatment and Management
- Hip disorders and treatments
- Family and Patient Care in Intensive Care Units
- Advanced Wireless Network Optimization
- Prostate Cancer Diagnosis and Treatment
- Interconnection Networks and Systems
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
- Palliative Care and End-of-Life Issues
- Anesthesia and Pain Management
- Power Line Communications and Noise
- Bone fractures and treatments
- Pharmacy and Medical Practices
- Pelvic and Acetabular Injuries
Université de Caen Normandie
2024
University of British Columbia
2003-2024
University of Warwick
2023
Vanderbilt University Medical Center
2021
University of Alberta
2016-2018
University of California, Irvine Medical Center
2018
University of California, Irvine
2018
Key points Retigabine is a KCNQ voltage‐gated potassium channel opener that was recently approved as an add‐on therapeutic for patients with drug‐resistant epilepsy. exhibits very little specificity between most subtypes, and there interest in generating more potent specific openers. The present study describes the marked of ICA069673 KCNQ2 vs . KCNQ3, exploits this property to investigate determinants subtype specificity. acts on binding site voltage‐sensing domain distinct from putative...
Background: Distal femur fractures are known to have challenging nonunion rates. Despite various available treatment methods aimed improve union, optimal interventions yet be determined. Importantly, there remains no standard agreement on what defines radiographic union. Although proposed criteria of defining union exist in the literature, is clear consensus which provide most precise measurement. The use inconsistent measures fracture healing between studies can problematic and limits their...
No AccessJournal of UrologyAdult Urology1 Jul 2021MOSESTM Technology for Holmium Laser Enucleation the Prostate: A Prospective Double-Blind Randomized Controlled Trial Nicholas L. Kavoussi, Naren Nimmagadda, Jennifer Robles, Connor Forbes, Alice Wang, Benjamin Stone, and Nicole Miller KavoussiNicholas Kavoussi *Correspondence: Department Urology, Vanderbilt University Medical Center, 1211 Center Dr., Nashville, Tennessee 37212 telephone: 443-465-1485; FAX: 615-936-1590; E-mail Address:...
KCNQ2-5 (Kv7.2-Kv7.5) channels are strongly influenced by an emerging class of small-molecule channel activators. Retigabine is the prototypical KCNQ activator that thought to bind within pore. It requires presence a Trp side chain conserved among retigabine-sensitive but absent in retigabine-insensitive KCNQ1 subtype. Recent work has demonstrated certain openers insensitive mutations this Trp, and their effects instead abolished or attenuated voltage-sensing domain (VSD). In study, we...
Ion channels encoded by KCNQ2-5 generate a prominent K+ conductance in the central nervous system, referred to as M current, which is controlled membrane voltage and PIP2. The voltage-gated potassium are targeted variety of activating compounds that cause negative shifts dependence activation. underlying pharmacology these effects growing interest because possible clinical applications. Recent studies have revealed multiple binding sites mechanisms action KCNQ activators. For example,...
Introduction Complex regional pain syndrome (CRPS) is a common complication following distal radius fractures that difficult to diagnose and can lead permanent disability. While various proposed prophylaxis treatment modalities exist, high-quality evidence guiding practice limited. This survey of Orthopaedic Trauma Association (OTA) Canadian (COA) members was conducted with the primary aim assessing patterns in complicated CRPS. Methods An electronic distributed practicing orthopaedic...
Administration of oral corticosteroids at the onset an upper respiratory tract infection (URTI) can be effective in management acute asthma exacerbations children. This study was designed to identify barriers parent-initiated implementation clinical practice guideline-recommended use for prophylaxis against severe Twenty-seven children who presented BC Children’s Hospital with URTI-induced were recruited. Parents received a filled prescription course used earliest their child’s next URTI....
The transition from choosing to initiating home dialysis therapies (HDTs) is not clearly standardized for patients and staff, causing increased anxiety suboptimal self-management chronic kidney disease (CKD) patients. At BC Renal, a "Transition HDTs" guidebook (the Guide) was designed, outlining step-wise approach transitioning HDTs patients, help address some of these concerns.We used the Logic Model evaluation framework assess value Guide improve patient staff experience with HDTs.This...
Aim: Limb reconstruction with external fixators requires appropriate pain management to promote effective analgesia and healing while minimising adverse events of the analgesic technique used.The objective this prospective case series was evaluate a multimodal regimen designed reduce opioid requirements hence opioid-related side effect profile.Materials methods: A cohort patients undergoing lower limb surgery (LRS) were managed through an evidence-informed guideline (MMAG), including...
The X‐chromosome‐linked inhibitor of apoptosis protein (XIAP) plays a crucial role in controlling cell survival across multiple regulated death pathways and coordinating range inflammatory signalling events. discovery selective inhibitors for XIAP‐BIR2, able to disrupt the direct physical interaction between XIAP RIPK2, offer promising therapeutic options NOD2‐mediated diseases like Crohn's disease, sarcoidosis, Blau syndrome. objective this study was design, synthesize, evaluate small...
This paper presents theoretical and numerical results on the effect of bridged taps channel capacity unshielded twisted pair telephone wiring used in very-high-speed digital subscriber line broadband access systems.
Background Giant adenomas are >4 cm and represent 5 to 14% of all adenomas. The most typical presenting symptom is vision loss. authors describe an unusual case a giant, recurrent atypical adenoma with severe mechanical neck pain unilateral hypoglossal nerve palsy.
Introduction: Overactive bladder and urge urinary incontinence affect millions of women men results in billions dollars health-care expenses. First- second-line therapy includes behavioral modifications and/or pharmacotherapies however, many patients' symptoms remain or progress on these treatments. There has been concern regarding the detrimental side effects most widely prescribed medications for symptom management.Areas covered: As a result, there increased interest continuous sacral...
Abstract Alzheimer’s disease (AD) and other tauopathies are characterized by the aggregation of tau into soluble insoluble forms (including tangles neuropil threads). In humans, a fraction both phosphorylated non-phosphorylated N-terminal to mid-domain species, including aggregated forms, secreted cerebrospinal fluid (CSF). Some these CSF species can be measured as diagnostic prognostic biomarkers, starting from early stages disease. While in animal models AD pathology, aggregates have been...
Presents information on the ISSCC 2018,