A5010558362- Optical Imaging and Spectroscopy Techniques
- Thermoregulation and physiological responses
- Photoacoustic and Ultrasonic Imaging
- Advanced Fluorescence Microscopy Techniques
- Optical Coherence Tomography Applications
- Infrared Thermography in Medicine
- Quantum optics and atomic interactions
- Laser Applications in Dentistry and Medicine
- Electrowetting and Microfluidic Technologies
- Olfactory and Sensory Function Studies
- Random lasers and scattering media
- Blood properties and coagulation
- Skin Protection and Aging
- Angiogenesis and VEGF in Cancer
- Hemodynamic Monitoring and Therapy
- Optical Polarization and Ellipsometry
- Neuroscience and Neural Engineering
- Quantum and electron transport phenomena
- Neurological Disease Mechanisms and Treatments
- Microfluidic and Bio-sensing Technologies
- Diagnosis and Treatment of Venous Diseases
- Cold Atom Physics and Bose-Einstein Condensates
- Venous Thromboembolism Diagnosis and Management
- Climate Change and Health Impacts
- Spectroscopy and Laser Applications
Princess Margaret Cancer Centre
2021-2023
University Health Network
2023
Gwangju Institute of Science and Technology
2017-2021
The strong optical scattering of biological tissue confounds our ability to focus light deeply into the brain beyond depths a few hundred microns.This challenge can be potentially overcome by exploiting wavefront shaping techniques which allow focused through or inside media.However, these require medium static, as changes in arrangement scatterers between recording and playback steps reduce fidelity that is formed.Furthermore, thickness increases, influence dynamic nature becomes more...
Speckle-based methods are popular non-invasive, label-free full-field optical techniques for imaging blood flow maps at single vessel resolution with a high temporal resolution. However, conventional speckle approaches cannot provide an absolute velocity map magnitude and direction. Here, we report image velocimetry (OSIV) technique measuring the quantitative vector by utilizing particle cross-correlations. We demonstrate that our OSIV instrument has linearity range up to 7 mm/s, higher than...
In microscopic imaging of biological tissues, particularly real-time visualization neuronal activities, rapid acquisition volumetric images poses a prominent challenge. Typically, two-dimensional (2D) microscopy can be devised into an system with 3D capability using any varifocal lens. Despite the conceptual simplicity, such upgrade yet requires additional, complicated device components and usually suffers from reduced rate, which is critical to properly document neurophysiological dynamics....
The hippocampus is associated with memory and navigation, the rodent provides a useful model system for studying neurophysiology such as neural plasticity. Vascular changes at this site are closely related to brain diseases, Alzheimer's disease, dementia, epilepsy. imaging around in mice may help further elucidate mechanisms underlying these diseases. Optical coherence tomography angiography (OCTA) an emerging technology that can provide label-free blood flow information. As deep structure...
Platelet aggregation and adhesion are critically involved in both normal hemostasis thrombosis during vascular injury. Before any surgery, it is important to identify the number of platelets their functionality reduce risk bleeding; therefore, platelet function testing a requirement. We introduce novel evaluation method assessing with laser speckle contrast imaging. The decorrelation time (SDT) blood flowing through microfluidic channel chip provides quantitative measure aggregation....
Red blood cells (RBCs) undergo irreversible biochemical and morphological changes during storage, contributing to the hemorheological of stored RBCs, which causes deterioration microvascular perfusion in vivo. In this study, a home-built optofluidic system for laser speckle imaging flowing RBCs through transparent microfluidic channel was employed. The decorrelation time (SDT) provides quantitative measure RBC changes, including aggregation microchannel. SDT relative light transmission...
This publisher’s note reports that corrections were made to the funding and acknowledgments in Optica 8 , 1092 ( 2021 ) OPTIC8 2334-2536 10.1364/OPTICA.422871 .
SignificanceLymphatic and peripheral nervous system imaging is of prime importance for monitoring various important pathologic processes including cancer development metastasis, response to therapy.AimOptical coherence tomography (OCT) a promising approach this task but challenged by the near-transparent nature these structures. Our aim detect differentiate semi-transparent materials using OCT texture analysis, toward label-free neurography lymphography.ApproachWe have recently demonstrated...
A. Abstract Background Ischemic stroke typically accompanies numerous disorders ranging from somatosensory dysfunction to cognitive impairments, inflicting its patients with various neurologic symptoms. Among pathologic outcomes, post-stroke olfactory is frequently observed. Despite the well-known prevalence, therapy options for such compromised olfaction are limited, likely due complexity of bulb architecture, which encompasses both peripheral and central nervous systems. As...
We developed a speckle based imaging technique that can provide absolute blood flow velocity noninvasively. demonstrated this the speed and direction in an vivo mouse mesentery vessel.
Abstract Significance Lymphatic and peripheral nervous system imaging is of prime importance for monitoring various important pathologic processes including cancer development, metastasis, response to therapy. Aim Optical coherence tomography (OCT) a promising approach this task but challenged by the near-transparent nature these structures. Our aim detect differentiate semi-transparent materials using OCT texture analysis, towards label-free neurography lymphography. Approach We have...
Abstract Speckle based methods are popular non-invasive, label-free full-field optical techniques for imaging blood flow maps at single vessel resolution with a high temporal resolution. However, conventional speckle approach cannot provide an absolute velocity map magnitude and direction. Here, we report novel image velocimetry (OSIV) technique measuring the quantitative vector by utilizing particle cross-correlations. We demonstrate that our OSIV instrument has linearity range up to 7...
Abstract In microscopic imaging of biological tissues, particularly real-time visualization neuronal activities, rapid acquisition volumetric images poses a prominent challenge. Typically, two-dimensional (2D) microscopy can be devised into an system with 3D capability using any varifocal lens. Despite the conceptual simplicity, such upgrade yet requires additional, complicated device components and suffers reduced rate, which is critical to document dynamics properly. this study, we...