A5019294859- Helicobacter pylori-related gastroenterology studies
- Neuroscience, Education and Cognitive Function
- Educational Research and Science Teaching
- Cellular transport and secretion
- Estrogen and related hormone effects
- Hibiscus Plant Research Studies
- Erythrocyte Function and Pathophysiology
- Educational Outcomes and Influences
- Research on Leishmaniasis Studies
- Educational Innovations and Technology
- Thyroid Disorders and Treatments
- Science and Education Research
- Gastric Cancer Management and Outcomes
- Berberine and alkaloids research
- Toxin Mechanisms and Immunotoxins
- Endometriosis Research and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Hereditary Neurological Disorders
- Genetic Neurodegenerative Diseases
- Educational methodologies and cognitive development
- Neuroscience and Neuropharmacology Research
- Trypanosoma species research and implications
- Pregnancy and preeclampsia studies
- Phytochemical Studies and Bioactivities
- Sleep and Wakefulness Research
Instituto de Medicina y Biología Experimental de Cuyo
2011-2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2010-2023
University of Mendoza
2021-2023
Universidad Nacional de Cuyo
2012-2023
Instituto de Histología y Embriología de Mendoza
2012-2018
Instituto Interdisciplinario de Ciencias Básicas
2012
Leishmaniasis is a neglected disease caused by flagellated parasites of the Leishmania genus affecting more than 10 million people worldwide. Current treatments for leishmaniasis involve administration poorly tolerated drugs with toxic side effects in patients. There an imperative necessity novel compounds to treat this disease. One most used strategies search different antiparasitic screening purified plant molecules. The diterpenes 12-hydroxy-11,14-diketo-6,8,12-abietatrien-19,20-olide...
The aqueous extract of the Argentinean native plant, Prosopis strombulifera (PsAE), presents cytotoxicity against human cancer cell lines by inducing cytostasis, necrosis and apoptosis; with diminution clonogenic survival; without genotoxic effects nor oral animal toxicity. Until now, chemical composition its in vivo antitumoral properties remain unknown; these studies are aim current work. PsAE was characterized fingerprinting metabolome identified tandem UHPLC-PDA-HESI-Q-orbitrap® mass...
Neuronal excitotoxicity induced by glutamatergic receptor overstimulation contributes to brain damage. Recent studies have shown that lysosomal membrane permeabilization (LMP) is involved in ischemia-associated neuronal death. In this study we evaluated the effect of neonatal hypoxia-ischemia (HI), as a model excitotoxicity, on integrity throughout distribution proteins cathepsin D and prosaposin. Rat pups (7 days old) Wistar Kyoto strain were submitted HI they euthanized 4 after treatment...
Cancer cells secrete procathepsin D, and its secretion is enhanced by estradiol. Although alterations in the pro-enzyme intracellular transport have been reported, mechanism which it secreted remains poorly understood. In this work, we studied influence of estradiol on expression distribution cation-dependent mannose-6-phosphate receptor (CD-MPR), would be a key molecule to ensure proper localization enzyme lysosomes breast cancer cells. Immunoblotting studies demonstrated that CD-MPR higher...
Prosopis strombulifera (Lam.) Benth is a rhizomatous shrub native from different zones of Argentine Republic. P. aqueous extract (PsAE) has effects and several biological activities have been reported. The goal this study was to analyze the activity PsAE on murine model cutaneous leishmaniasis caused by Leishmania amazonensis. orally administered at 150 mg/animal/day BALB/c mice infected in right footpad (RFP) with 1 × 105 promastigotes L. As chemotherapeutic control treatment, animals...
In brief The endocrine and immunological disruption induced by hyperthyroidism could alter gestation, placenta, fetal development. This study suggests an role of thyroid hormones in gestation. Abstract Thyroid dysfunctions lead to metabolic, angiogenic, developmental alterations at the maternal–fetal interface that cause reproductive complications. (THs) act through their nuclear receptors interact with other steroid hormone receptors. Currently, regulation status has been characterized a...
Este estudio aborda la problemática, dentro del campo didáctico de enseñanza Biología Humana, construcción conceptos sobre el funcionamiento cerebral en interacción con sustancias adictivas, marco educación secundaria. El desarrollo mismo se enfocó en: 1) rescatar las concepciones los estudiantes acerca estructura-función sistema nervioso general; 2) relevar relación que establecen entre algunas psicoactivas (alcohol, marihuana y tabaco), impacto otras funciones orgánicas; 3) potencialidad...
Los Diseños Curriculares para la Educación Secundaria señalan como objeto de estudio las acciones protección y promoción salud tanto los conceptos sobre inmunidad, en el marco regulación control organismo humano. objetivos del trabajo fueron: detectar solidez conocimientos inmunidad vacunas estudiantes secundaria evaluar constructo posicionamiento ante vacunación. El se desarrolló una muestra poblacional N=89 Tercer Año ciudad Mendoza, a cuales les aplicó instrumentos momentos pre post-test,...
Este estudio aborda la problemática, dentro del campo didáctico de enseñanza Biología Humana, construcción conceptos sobre el funcionamiento cerebral en interacción con sustancias adictivas, marco educación secundaria. El desarrollo mismo se enfocó en: 1) rescatar las concepciones los estudiantes acerca estructura-función sistema nervioso general; 2) relevar relación que establecen entre algunas psicoactivas (alcohol, marihuana y tabaco), impacto otras funciones orgánicas; 3) potencialidad...